Bioreactors Market Growth Report | Size, Share & Future Outlook 2030

Bioreactors Market Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Scale (Lab-Scale Production, Pilot-Scale Production, and Full-Scale Production), Application (Microbial Application, Cell Culture Application, and Others), Technology (Fed-Batch Bioreactors and Perfusion Bioreactors), End User (Biopharma Manufacturers, Research and Development Organizations, and Contract Manufacturing Organization), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America)

Publication Month : Nov 2023

  • Report Code : TIPHE100000880
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 176
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[Research Report] The bioreactors market size is expected to grow from US$ 3,643.00 million in 2022 to US$ 6,570.76 million by 2030; it is estimated to register a CAGR of 7.65% from 2022 to 2030.

Analyst’s Viewpoint

The bioreactors market analysis explains market drivers and future trends of the market. Factors such as the increasing adoption of single-use bioreactors and rapid growth of the pharmaceutical and biotechnology industry are the key drivers behind the market development. However, the stringent regulatory framework is hampering the market growth. Further, the technological advancements in bioreactors are expected to introduce new trends in the market during 2022–2030. Based on Scale, the full-scale production segment is anticipated to register the highest CAGR of 8.32% during the forecast period. Based on application, the cell culture application segment held the largest market share in 2022. Based on technology, the perfusion bioreactors segment is anticipated to register a higher CAGR of 8.58% during the forecast period.

By end user, the research and development organizations segment held the largest share of the market in 2022 and is anticipated to register the highest CAGR of 8.34% in the market during the forecast period.

A bioreactor is an instrument used to cultivate organisms (such as yeast, bacteria, or animal cells) under regulated circumstances used in the manufacturing of medicines, vaccines, and antibodies. In bioreactors, whole cells or cell-free enzymes metabolize the input components into biochemical products and/or less undesired byproducts.

Market Insights

Increasing Adoption of Single-Use Bioreactors and Rapid Growth of Pharmaceutical and Biotechnology Industry

Various manufacturers are developing single-use bioreactors (SUBs) as they are robust and provide the high performance required for commercial manufacturing of biopharmaceuticals. Advantages such as film technologies, stirring mechanisms, bioreactor designs, and sensor systems have contributed toward the increasing adoption of disposable reactors from the lab to the production scale. The single-use bioreactors provide next-generation cell and gene

therapies and continuous bioprocessing. The advancements in cell-culture processes have developed higher titers and cell densities, which have facilitated the adoption of SUBs.

SUBs reduce the risks of contamination and decrease production turnaround times. In the last few years, the use of single-use bioreactors has increased in modern biopharmaceutical processes owing to their unique ability to enhance flexibility, reduce investment, and limit operational costs. Also, many companies have developed single-use bioreactors for producing a wide range of therapeutics. The reduction in validation time has been one of the essential benefits of single-use bioreactors. Therefore, the rising adoption of single-use bioreactors for upstreaming bioprocessing drives market growth.

In recent years, the pharmaceutical industry has been growing at an unprecedented pace. Big pharmaceutical companies and contract research organizations (CROs) are coming up with new medicines and therapy forms to treat a wide range of indications. The biopharmaceuticals market is increasing. The strong demand for biologics and biosimilars has driven the growth of the industry. The biopharmaceutical industry is one of the most significant contributors to the economy. Apart from this, increasing approvals in gene and cell therapies are favoring market growth. The approved gene therapies are Glybera-used to treat Lipoprotein Lipase Deficiency and Strimvelis- treating ADA-Severe Combined Immuno Deficiency. Thus, the factors mentioned above are increasing the demand for the large-scale production of various therapeutics, thereby facilitating the growth of the bioreactors market globally.

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Bioreactors Market: Strategic Insights

bioreactors-market
Market Size Value inUS$ 3,643.00 million in 2022
Market Size Value byUS$ 6,570.76 million by 2030
Growth rateCAGR of 7.65% from 2022 to 2030
Forecast Period2022-2030
Base Year2022
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Future Trend

Technological Advancements in Bioreactors

Advancement in the field of bioreactors has opened many opportunities for the market players. Leading players have come up with innovative products in the last few years. The improvement in the bioreactors offers a faster and easier production of biopharmaceuticals at reduced production costs. In February 2021, WuXi Biologics' MFG5 Drug Substance (DS) manufacturing facility in China launched a GMP operation with a capacity of 36,000L and deployed nine 4,000L single-use bioreactors. As a major milestone in the company's global capacity planning, the GMP implementation of MFG5 increases WuXi Biologics' current capacity to 90,000L, significantly expanding its ability to support global partners.​

The new bioreactors are developed for the growth of adherent cells on microcarriers that enable rapid, scalable cell culture processes in the development of vaccines. The launch of such new bioreactors enhanced the portfolio of the company in the bioreactors market. In June 2022, ABEC announced that mAbxience plans to add a 4,000L single-use custom single-run (CSR) bioreactor to its state-of-the-art cGMP facility in León, Spain. In May 2021, Beckman Coulter Life Sciences launched its next-generation Biolector XT microbioreactor in Germany. The BioLector XT microbioreactor enables monitoring of cultivation parameters, high-throughput strain screening, and optimization of feeding strategy.

Advancement in bioreactors has added various solutions for most industries, such as pharmaceutical, petrochemical, food, and agriculture. Therefore, technological advancements are expected to boost innovations in the bioreactors market in the coming years.

Report Segmentation and Scope

The “Global Bioreactors Market” is segmented on the basis of Scale, Application, Technology, End User, and Geography.

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Scale-Based Insights

The bioreactors market, by scale, is segmented into lab-scale production, pilot-scale production, and full-scale production. The pilot-scale production segment held a larger market share in 2022. However, the full-scale production segment is anticipated to register a higher CAGR during the forecast period. For laboratory purposes, benchtop bioreactors are used widely. They are used for cultures up to 15L. Benchtop bioreactors are used for growth studies of microbial, mammalian, insect, and plant cells, culture media optimization, multivariate process optimization studies, and small-scale protein and mAB expression. These bioreactors have been used extensively for processes such as process development and optimization, scale-up and scale-down studies, seed expansion, cell bank production, and protein supply. Infors AG, Sartorius AG, and Eppendorf are among the companies offering benchtop bioreactors. Sartorius offers a wide range of benchtop bioreactors. These benchtop bioreactors are used for cell cultivation as well as for microbial fermentation. These are autoclavable culture vessels and are available from 1–10L and single-use vessels of 250ml and 2L. Benefits offered by benchtop reactors are saving valuable bench space in the development lab, easy cleaning, additional storage space for a tidy workplace, and increased measurement safety and control of the process according to the latest standards.

Bioreactors Market, by Scale  – 2022 and 2030

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Application-Based Insights

Based on application, the bioreactors market is segmented into microbial application, cell culture application, and others. The cell culture application segment held the largest market share in 2022. However, the microbial application segment is anticipated to register the highest CAGR during the forecast period.

Microbial cultivation includes the cultivation of bacterial and viral cell cultures for various purposes, such as for basic research and development and the manufacturing of biopharmaceuticals, chemicals, and other products. The bacterial culture of E. coli is the preferred microorganism for the production of recombinant proteins. It is widely used for cloning, genetic modification, and small-scale production for research purposes. Additionally, bioreactors are crucial for the production of large-scale viral vaccines in cell culture. According to an article published by Frontiers in February 2020, bioreactors have evolved into a platform for producing various viral vectors, live viruses, and virus-based vaccines using cells. The development of fed-batch culture, perfusion culture, and genetic engineering has contributed to this advancement. In addition, the application of smart sensors and actuators to bioreactor control systems holds great promise for improving bioprocess control in the near future. As vaccine production processes have advanced, more scalable bioreactors and cell lines with high virus affinity have been utilized to produce several vaccines.

Technology-Based Insights 

Based on technology, the bioreactors market is bifurcated into fed-batch bioreactors and perfusion bioreactors. The fed-batch bioreactors segment held a larger market share in 2022.

In fed-batch systems, fresh medium or medium components are continuously, intermittently, or singularly added while the batch volume increases over time. During fed-batch fermentation, the nutritional environment can be maintained at a consistent level. This can prevent the production of byproducts that are typically caused by high concentrations of substrate. By using this method, it is possible to extend the operating time and achieve high cell concentrations, which can lead to improved productivity (measured as mass of product per volume and time). This method is particularly useful in the production of growth-associated products. Due to the advantages mentioned above demand of fed-batch bioreactors used for the production of cell cultures is growing.

End User-Based Insights

The bioreactors market, by the end user, is bifurcated into biopharma manufacturers, research and development organizations, and contract manufacturing organizations (CMOs). The research and development organizations segment held the largest share of the market in 2022 and is anticipated to register the highest CAGR in the market during the forecast period.

In industries such as biotechnology, healthcare, and pharmaceuticals, research and development play a crucial role. Research and development organizations are engaged in the processes and activities to innovate and introduce new products, technologies, and services in the bioreactor market. Research and development is also important to accelerate product introductions. The growth of research and development organizations is majorly attributed to the increasing adoption of bioreactors for research and innovation processes. Additionally, the research institutes are investing heavily to boost the bioprocesses, leading to market growth.

Regional Analysis

The global bioreactors market, by region, is segmented into North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. The North America regional market is expected to grow with a CAGR of 6.81% during 2022–2030.

The North America bioreactors market is segmented into the US, Canada, and Mexico. The market growth in North America is attributed to the increasing demand for bioreactor systems from biopharmaceutical and biotechnology companies, the presence of market players, and growing R&D by various academic and research institutes. In addition, rising research in pharmaceutical and biotechnology companies is expected to stimulate the growth of the bioreactors market in North America. The US is the largest market for bioreactors—several market players in the US manufacture bioreactors for various applications in pharmaceutical and biotechnology companies. Launch of new bioreactors, geographical expansion, and partnerships by market players drive the growth of the market. For instance, in April 2023, BioMADE announced five new projects focused on addressing the research and adoption gaps in bioindustrial manufacturing in the US by advancing bioreactor technology.

The report profiles leading players operating in the global bioreactors market. These include Sartorius AG, PBS Biotech, Merck KGaA, Cellexus International Ltd, General Electric Co, Thermo Fisher Scientific Inc, bbi-biotech GmbH, Pall Corp, Applikon Biotechnology BV, and Solaris Biotechnology SRL. These companies focus on new product launches and geographical expansions to meet the growing consumer demand worldwide and increase their product range in specialty portfolios. They have a widespread global presence, which allows them to serve a large set of customers and subsequently increase their market share.

Various initiatives taken by key players operating in the bioreactors market are listed below:

  • In August 2023, Sartorius and Repligen collaborated to launch an advanced bioreactor system that incorporates Repligen XCell ATF upstream intensification technology into Sartorius’ Biostat STR bioreactor. This collaboration aims to simplify intensified seed train and N perfusion implementation for biopharmaceutical manufacturers, as per the announcement by both companies.
  • In April 2023, Cytiva launched X-platform bioreactors to simplify single-use upstream bioprocessing operations. These bioreactors are initially available in 50 and 200 L sizes and come equipped with Figurate automation solution software. They offer a range of benefits that can help increase process efficiency by improving ergonomics, enhancing production capability, and simplifying supply chain operations.
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Scale, Application, Technology, End User, and Geography

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

This text is related
to country scope.

Frequently Asked Questions


What is the market CAGR value of bioreactors market during forecast period?

The CAGR value of the bioreactors market during the forecasted period of 2022-2030 is 7.65%.

What are bioreactors?

A bioreactor is an instrument used to cultivate organisms (such as yeast, bacteria, or animal cells) under regulated circumstances used in the manufacturing of medicines, vaccines, and antibodies. In bioreactors, whole cells or cell-free enzymes metabolize the input components into biochemical products and/or less undesired byproducts.

Which technology segment leads the bioreactors market?

The fed-batch bioreactors segment held the largest share of the market in the global breath analyzers market and held the largest market share of 62.1% in 2022.

What are the driving factors for the bioreactors market across the globe?

Key factors that are driving the growth of this market are the increasing adoption of single-use bioreactors and rapid growth of the pharmaceutical and biotechnology industry.

Which application held the largest share in the bioreactors market?

The cell culture application segment dominated the global bioreactors market and held the largest market share of 48.6% in 2022.

Who are the key players in the bioreactors market?

The bioreactors market majorly consists of the players such Sartorius AG, PBS Biotech, Merck KGaA, Cellexus International Ltd, General Electric Co, Thermo Fisher Scientific Inc, bbi-biotech GmbH, Pall Corp, Applikon Biotechnology BV, and Solaris Biotechnology SRL.

Which are the top companies that hold the market share in bioreactors market?

Merck KGaA and Thermo Fisher Scientific, Inc. are the top two companies that hold huge market shares in the bioreactors market.

Which region is expected to witness significant demand for bioreactors market in the coming years?

Global bioreactors market is segmented by region into North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. The North America regional market is expected to grow with a CAGR of 6.81% during 2022–2030. The market growth in North America is attributed to the increasing demand for bioreactor systems from biopharmaceutical and biotechnology companies, the presence of market players, and growing R&D by various academic and research institutes. Europe held the second largest market share of the bioreactors market in 2022. With several European market players focusing on research and development activities in the field of bioreactors, the regional market for bioreactcors market is likely to propel in Europe region during the forecast period.

The List of Companies - Bioreactors Market

  1. Sartorius AG
  2.  PBS Biotech
  3.  Merck KGaA
  4.  Cellexus International Ltd
  5.  General Electric Co
  6.  Thermo Fisher Scientific Inc
  7.  bbi-biotech GmbH
  8.  Pall Corp
  9.  Applikon Biotechnology BV
  10.  Solaris Biotechnology SRL

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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