The regenerative dentistry market size is projected to reach US$ 4.72 billion by 2031 from US$ 2.32 billion in 2024. The market is expected to register a CAGR of 10.8% during 2025–2031. Increased adoption of tissue regeneration is likely to bring new market trends during the forecast period.
As people age, they are more likely to encounter dental issues, including tooth loss, which increases the demand for dental procedures, including regenerative dentistry. According to the WHO facts published in October 2022, one in six individuals worldwide will be aged 60 or over by 2030. By then, the number of people aged 60 and above will increase from 1 billion in 2020 to 1.4 billion. The population of people aged 60 years and above will quadruple to 2.1 billion by 2050. It is anticipated that the population of those aged 80 or older will triple between 2020 and 2050, reaching 426 million. The rate of gum disease increases with age, and adults aged 65 years and above have some form of gum disease. As per the Centers for Disease Control and Prevention, in the US, ~70.1% of adults over the age of 65 had periodontal disease in 2020.
According to global estimates, the prevalence of edentulism (complete tooth loss) among individuals aged 65–74 is as high as 35% in upper-middle-income countries. In contrast, low-income countries report a lower prevalence (10%), highlighting disparities in access to preventive and restorative dental care. Beyond aging populations, vulnerable groups such as homeless individuals experience a disproportionately high burden of oral diseases. A study on homeless patients by European Review for Medical and Pharmacological Sciences found that 25.45% suffered from edentulism or missing teeth. Also, 80% reported acute tooth pain. The lack of access to early dental intervention in such groups necessitates regenerative solutions that can restore lost dental structures and improve quality of life. Also, advancements in regenerative dental treatments, such as biomaterials and stem cell therapies, accelerate global market growth.
The regenerative dentistry market is expanding due to the rising prevalence of dental disorders, soaring aging population, and surging demand for cosmetic dentistry. Prominent players operating in the market are focusing on innovation and collaboration for enhanced product availability. However, the high-cost barriers in dental regeneration treatment hinder the regenerative dentistry market growth. Market players in regenerative dentistry can capitalize on rising demand for biomaterials, minimally invasive solutions, and digital integration, which is driven by aging populations and cosmetic dentistry trends are providing opportunities in the regenerative dentistry market growth.
The increasing demand for cosmetic dentistry is driving the growth of the regenerative dentistry market. A rising number of patients seek procedures such as dental implants, veneers, and gum contouring to enhance their smiles. This trend is fueled by rising disposable incomes, social media influence, and advancements in minimally invasive techniques.
Europe, along with the Americas, hosts a significant portion of the global dental workforce, with 69% of the world’s 1.6 million dentists serving only 27% of the global population. This concentration of skilled dental professionals ensures that European patients have better access to advanced cosmetic and regenerative treatments than other regions. Meanwhile, Africa, with only 1% of the global dental workforce, faces challenges in meeting oral health needs. The availability of cutting-edge regenerative solutions in Europe—such as stem cell therapy and biomaterial implants—caters to functional and aesthetic demands.
In recent years, an increasing number of people have sought to have teeth that are straight and free of chips or other noticeable imperfections. Dentists have responded to these consumer demands, offering cosmetic procedures, such as implants and veneers. Baby boomers and millennials are the primary contributors to the growth of the cosmetic dentistry industry. Dental implants are commonly used in the dental treatments of older populations. However, the share of the younger population who are opting for dental implantation methods instead of bridges is rising. Aside from restoring teeth functions, dental implants favor the inclination of people toward natural-looking teeth that can last as long as regular teeth, improve a person's physical appearance, and provide comfort and convenience, unlike removable dentures. Dental cosmetic surgeries are among the most familiar cosmetic procedures worldwide due to their easy accessibility and practicality.
With ongoing advancements in research and greater awareness of regenerative options, the demand for these treatments is surging, benefiting practitioners and patients seeking superior aesthetic results.
Technological advancements are creating significant opportunities in the regenerative dentistry market, revolutionizing dental procedures and enhancing patient outcomes. Here are key innovations driving the transformation:
Customized Implants and Prosthetics: 3D printing technology allows for the creation of patient-specific dental implants and prosthetics. Clinics and labs are adopting 3D bioprinting to produce customized dental crowns, bridges, and implants with high precision. This trend enhances the fit and appearance while reducing surgery time and improving success rates. Companies such as Stratasys are already providing dental-specific 3D printers, creating opportunities for greater personalization in treatments. Clinics such as DentalPro have begun using 3D-printed bone grafts, enabling personalized treatment plans that align closely with individual patient needs.
• Stem Cell Therapy for Tooth Regeneration:
Dental Pulp and Bone Regeneration: Researchers are exploring the potential of dental stem cells for regenerating dental tissues. Stem cells derived from oral tissues, such as dental pulp and periodontal ligaments, are being investigated for their ability to regenerate damaged tissues and even whole teeth. Products, including Tooth Bank's Dental Stem Cells, launched in 2022, facilitate the collection and preservation of stem cells from extracted teeth. They provide valuable biological material for future regenerative procedures.
• Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF):
Enhanced Healing and Regeneration: PRP and PRF are adopted in Italy for soft tissue regeneration and bone healing. These treatments utilize a patient's platelets to stimulate faster healing after surgery and improve implant integration. Italian clinics are incorporating these therapies in procedures such as periodontal regeneration and implant surgeries. These procedures provide a minimally invasive and highly effective option for patients. Clinics such as Clinica Dental Mimmo are integrating PRP treatments into bone grafting procedures, significantly enhancing patient recovery times.
• Regenerative Materials:
Innovations in biomaterials, such as bioactive glass and hydroxyapatite composites, have improved the efficacy of grafts. Introduction of OsseoSpeed TRX implants by Dentsply Sirona has provided dentists with advanced solutions that promote osseointegration and support faster recovery.
• Integration of Artificial Intelligence (AI):
The incorporation of AI, particularly machine learning and deep learning, has transformed diagnostics, treatment planning, and regenerative procedures in dentistry. AI algorithms analyze extensive datasets to identify patterns and make informed decisions, enhancing the precision and efficiency of regenerative treatments.
• Tissue Engineering and Biomaterials:
Regenerative strategies that utilize scaffolds present opportunities to improve treatment options beyond the conventional repair methods used in root canal treatment (RCT) and vital pulp treatment (VPT). Scaffolds in regenerative medicine are usually three-dimensional (3D) porous biomaterials designed to provide structural support for regenerative processes and to facilitate the delivery of cells and/or bioactive agents.
These advancements are creating new opportunities for dental practitioners and businesses, enhancing the quality of care while enabling patient-specific treatments.
Key segments that contributed to the derivation of the regenerative dentistry market analysis are type, technology, application, age group, and end user.
The geographic scope of the regenerative dentistry market report mainly focuses on five regions: North America, Asia Pacific, Europe, South & Central America, and the Middle East & Africa. In terms of revenue, North America dominated the market in 2024. It is expected to continue its dominance in the global market during the forecast period. The US is the largest market for regenerative dentistry in the world. Cavities and gum disease are among the most preventable public health challenges in the US. According to the CDC, more than 90% of adults aged 20 to 64 have experienced at least one cavity in their lifetime. Nearly 21% of this same age group had one or more untreated decayed permanent teeth in 2024. The situation is concerning among children, with more than half (52%) of those aged 6 to 8 having encountered cavities in their primary teeth. Additionally, nearly 47% of adults aged 30 and older exhibit signs of gum disease, a condition that becomes more common as individuals age. As per the American Dental Association (2020), ~5 million people aged 65–74 are edentulous in the country.
The adoption of stem cell therapies and tissue engineering in regenerative dentistry in the US is transforming how dentists approach tooth repair, tissue regeneration, and the possibilities of whole-tooth engineering. Phase I and II clinical trials conducted in the US and internationally have shown the safety and initial effectiveness of stem cell-based dental regenerative procedures. However, many of these studies involve small sample sizes and have short follow-up periods. It highlights the necessity for larger, multicenter trials. Studies involving autologous dental pulp stem cells (DPSCs) combined with collagen scaffolds have reported positive pulp vitality responses and radiographic evidence of root maturation in immature permanent teeth. Likewise, clinical applications of SCAP-loaded hydrogels have demonstrated revascularization and apical closure in necrotic teeth. Thus, the increasing incidence of oral diseases and ongoing research initiatives are promoting the adoption of regenerative technologies in the US.
The regional trends and factors influencing the Regenerative Dentistry Market throughout the forecast period have been thoroughly explained by the analysts at Insight Partners. This section also discusses Regenerative Dentistry Market segments and geography across North America, Europe, Asia Pacific, Middle East and Africa, and South and Central America.
| Report Attribute | Details |
|---|---|
| Market size in 2024 | US$ 2.32 Billion |
| Market Size by 2031 | US$ 4.72 Billion |
| Global CAGR (2025 - 2031) | 10.8% |
| Historical Data | 2021-2023 |
| Forecast period | 2025-2031 |
| Segments Covered |
By Type
|
| Regions and Countries Covered | North America
|
| Market leaders and key company profiles |
The Regenerative Dentistry Market market is growing rapidly, driven by increasing end-user demand due to factors such as evolving consumer preferences, technological advancements, and greater awareness of the product's benefits. As demand rises, businesses are expanding their offerings, innovating to meet consumer needs, and capitalizing on emerging trends, which further fuels market growth.
Market players density refers to the distribution of firms or companies operating within a particular market or industry. It indicates how many competitors (market players) are present in a given market space relative to its size or total market value.
Major Companies operating in the Regenerative Dentistry Market are:
Disclaimer: The companies listed above are not ranked in any particular order.
The regenerative dentistry market is evaluated by gathering qualitative and quantitative data post primary and secondary research. This data includes important corporate publications, association data, and databases. Key developments witnessed in the regenerative dentistry market:
The "Regenerative Dentistry Market Size and Forecast (2021–2031)" report provides a detailed analysis of the market covering below areas:
Dentsply Sirona, Geistlich Pharma AG, Evonik Industries AG, ZimVie Inc., BioHorizons, Inc., Nobel Biocare, UBGEN Srl, B. & B. Dental S.r.l, Botiss Biomaterials GmbH, and Envista Holdings Corporation are among the key players operating in the market.
The regenerative dentistry market value is expected to reach US$ 4.72 billion by 2031.
The rising prevalence of dental disorders, soaring aging population, and surging demand for cosmetic dentistry are among the significant factors fueling the market growth.
North America dominated the regenerative dentistry market in 2024.
The increased adoption of tissue regeneration is likely to emerge as a new trend in the market in the coming years.
The market is expected to register a CAGR of 10.8% during 2025–2031.