Le marché du Diltiazem devrait atteindre 832,52 millions de dollars US d'ici 2028 contre 369,95 millions de dollars US en 2021 ; il devrait croître à un TCAC de 12,3 % de 2021 à 2028.
Des facteurs tels que l'augmentation de l'incidence des maladies cardiovasculaires et l'augmentation de la population âgée stimulent la croissance du marché. Cependant, les effets secondaires du diltiazem sont susceptibles d'entraver la croissance du marché.
Les maladies cardiaques sont principalement observées chez les personnes âgées en raison de leur faible immunité et d'autres problèmes de santé majeurs. Les facteurs généraux de vieillissement entraînent un raidissement du cur et des vaisseaux sanguins qui entraînent des troubles cardiaques. À mesure que l'âge augmente, la pression artérielle systolique augmente également et peut provoquer des maladies cardiovasculaires. Ainsi, l'hypertension artérielle est une cause fréquente de maladies cardiaques chez les personnes âgées de 75 ans et plus. La maladie coronarienne et l'insuffisance cardiaque sont les prochaines conditions causées. Bien que l'incidence des arythmies concerne les personnes de tous les groupes d'âge, son incidence augmente considérablement chez les personnes âgées.
Selon l'enquête Global Aging 2019, la population mondiale de personnes âgées de 65 ans et plus s'élevait à 703 millions en 2019. Le nombre de personnes âgées devrait doubler pour atteindre 1,5 milliard de personnes d'ici 2050. La fréquence d'une personne âgée de 65 ans et plus devrait passer de 1 habitant sur 11 en 2019 à 1 habitant sur six d'ici 2025. Ce groupe démographique est plus sensibles aux maladies cardiovasculaires, telles que les arythmies. De même, selon l'OMS, le pourcentage de personnes âgées de 60 ans et plus devrait atteindre 22 % d'ici 2050 contre 12 % en 2015. Selon le rapport « Older Americans 2016 : Key Indicators of Well-Being » de la Federal Interagency Forum sur les statistiques liées au vieillissement, 35,8 % des personnes âgées de 85 ans et plus souffraient d'un trouble cognitif léger ou extrême. De plus, selon le rapport 2017 sur le vieillissement de la population mondiale des Nations Unies, en 2017, 962 millions de personnes dans le monde étaient âgées de 60 ans et plus, et ce nombre devrait atteindre près de 2,1 milliards d'ici 2050.
< p>Selon le US Census Bureau, le nombre d'Américains âgés de 65 ans et plus devrait plus que doubler, passant de 46 millions en 2016 à plus de 98 millions d'ici 2060, la tranche d'âge des 65 ans et plus représentant environ 24 % de la population mondiale, contre 15 % en 2016. En 2017, l'Union européenne comptait la plus forte proportion de personnes âgées de 60 ans et plus (25 %). D'autres régions du monde connaissent également une population vieillissante croissante et, d'ici 2050, toutes les régions du monde, à l'exception de l'Afrique, compteront environ un quart ou plus de leurs habitants âgés de 60 ans et plus. Le nombre de personnes âgées dans le monde devrait atteindre 1,4 milliard de dollars américains d'ici 2030 et 2,1 milliards de dollars américains d'ici 2050 et dépassera 3,1 milliards de dollars américains d'ici 2100. La population âgée est plus susceptible d'avoir des présentations atypiques, des conditions comorbides, et des résultats défavorables. Les modifications structurelles et fonctionnelles du système cardiovasculaire associées au vieillissement sont les principales causes des maladies cardiovasculaires. Par conséquent, l'augmentation de la population gériatrique dans le monde entraîne une augmentation de l'incidence des maladies cardiovasculaires, ce qui renforce la croissance du marché du diltiazem.
Régions lucratives pour le marché du diltiazem
Insights sur le marché
Augmentation de l'incidence des maladies cardiovasculaires
Le diltiazem est un inhibiteur calcique. Il abaisse le rythme cardiaque et agit en relaxant les vaisseaux sanguins du corps et du cur. Le sang circule plus facilement et le cur travaille moins dur pour pomper le sang. Le diltiazem réduit la demande en oxygène du myocarde en réduisant la fréquence cardiaque, la pression artérielle et la contractilité cardiaque, ce qui représente également une bonne alternative pour le traitement de l'angor chronique stable. Le diltiazem a de puissants effets cardiovasculaires causés par ses actions sur les muscles lisses vasculaires, le myocarde ventriculaire et les tissus conducteurs spécialisés. Chez les individus ayant une fonction ventriculaire normale, il induit une vasodilatation coronarienne et périphérique, a un impact chronotrope et dromotrope négatif, et a peu ou pas d'effet inotrope négatif. Le diltiazem a une utilisation potentielle dans une grande variété de troubles cardiovasculaires. Il est extrêmement efficace pour soulager le spasme de l'artère coronaire associé à l'angor variant. Comparé aux nitrates chez les patients souffrant d'angor d'effort, le diltiazem a une efficacité similaire. Selon l'Organisation mondiale de la santé, les maladies cardiovasculaires (MCV) sont la première cause de décès dans le monde. Les maladies cardiovasculaires sont une cause majeure de morbidité et affectent plus de personnes que toute autre maladie. Quelques maladies cardiovasculaires sont les maladies cérébrovasculaires, les maladies coronariennes et les cardiopathies rhumatismales. La consommation de tabac, une mauvaise alimentation et l'inactivité physique sont parmi les principaux facteurs liés au mode de vie qui augmentent le risque de crises cardiaques et d'accidents vasculaires cérébraux. En outre, d'autres facteurs de risque pouvant entraîner des maladies cardiovasculaires sont l'hypertension artérielle, le diabète et l'augmentation du taux de cholestérol. La fibrillation auriculaire (FAib) est le type de trouble cardiaque le plus courant, où le cur bat trop vite, trop lentement ou une manière irrégulière. Les Centers for Disease Control and Prevention (CDC) ont estimé qu'entre 2,7 millions et 6,1 millions de personnes souffrent de fibrillation auriculaire aux États-Unis. En 2017, environ 166 793 certificats de décès mentionnent l'AFib et ont été la principale cause de décès dans 26 077 décès. Chaque année, plus de 454 000 hospitalisations et environ 158 000 décès sont signalés en raison de la fibrillation auriculaire aux États-Unis. En outre, la Société européenne de cardiologie a signalé que la fibrillation auriculaire est l'arythmie la plus courante et représente 0,28 % à 2,6 % des dépenses de santé dans les pays européens. Il a également mentionné que les patients souffrant de fibrillation auriculaire ont un risque cinq fois plus élevé de subir un accident vasculaire cérébral. De 20 à 30 % du total des AVC en Europe sont dus à la fibrillation auriculaire. Selon l'étude menée par la Société européenne de cardiologie en 2016, environ 7,6 millions de personnes âgées de 65 ans et plus dans l'UE souffraient de fibrillation auriculaire. La Société européenne de cardiologie a estimé que ce nombre devrait augmenter de 89 % d'ici 2060 et qu'environ 14,4 millions de personnes souffriront de fibrillation auriculaire. En outre, la prévalence de 7,8 % devrait atteindre 9,5 % en 2060. En outre, la prévalence de la fibrillation auriculaire en Asie-Pacifique est également en augmentation. Selon le rapport "BEYOND THE BURDEN : THE IMPACT OF ATRIAL FIBRILLATION IN ASIA PACIFIC" de Biosense Webster, publié en 2019, plus de 16 millions de personnes en Asie-Pacifique souffrent de fibrillation auriculaire AF, qui affecte les personnes d'âge moyen et les personnes âgées. population. Le rapport estime également que ce nombre atteindra environ 72 millions d'ici 2050.
Prévalence de la fibrillation auriculaire dans la région APAC (par pays)
Source : Rapport Biosense Webster : AU-DELÀ DU FARDEAU : LE IMPACT DE LA FIBRILLATION AURICULAIRE EN ASIE-PACIFIQUE
Les inhibiteurs calciques diltiazem (Cardizem) et vérapamil (Calan et Isoptin) sont efficaces pour le contrôle initial de la fréquence ventriculaire chez les patients atteints de fibrillation auriculaire. Ces agents sont administrés par voie intraveineuse en bolus jusqu'à ce que la fréquence ventriculaire ralentisse. De plus, le diltiazem réduit la conduction dans le nud auriculo-ventriculaire, ce qui est également utile pour le contrôle de la fréquence cardiaque chez les patients atteints de fibrillation auriculaire. Ainsi, la prévalence croissante de la fibrillation auriculaire à travers le monde entraîne la croissance du marché du diltiazem. Aperçus basés sur le type de produit En fonction du type de produit, le marché est segmenté en capsules, injection et comprimés. En 2021, le segment des comprimés détenait la plus grande part du marché, tandis que le segment des gélules devrait connaître le TCAC le plus rapide de 2021 à 2028.
Marché du diltiazem, par type de produit - 2021 et 2028 >
Application -Based InsightsBasé sur l'application, le marché est segmenté en angine, hypertension et autres. En 2021, le segment de l'hypertension détenait la plus grande part du marché, tandis que le segment de l'angine devrait croître au TCAC le plus rapide au cours des prochaines années. demandes à travers le monde, ce qui leur permet également de maintenir leur marque sur le marché mondial. >Injection
Par application
- Hypertension
- Angine
- Autres
Marché du diltiazem par géographie
- Amérique du Nord
- États-Unis
- Canada
- Mexique
- Europe
- France
- Allemagne
- Italie
- Royaume-Uni
- Espagne
- Reste de l'Europe
- Asie-Pacifique (APAC)
- Chine
- Inde
- Corée du Sud
- Japon
- Australie
- Reste de l'APAC
- Moyen-Orient et Afrique (MEA)
- Afrique du Sud
- Arabie saoudite
- EAU
- Reste de la MEA
- Amérique du Sud et centrale (SCAM)
- Brésil
- Argentine
- Reste de la SCAM
Profils d'entreprise
- Bausch Health
- Teva Pharmaceutical Industries Ltd
- Mylan NV
- Athenex
- Pfizer, Inc,
- Glenmark
- Sandoz (Novartis Ag)
- Sun Pharmaceutical Company Ltd
- Hikma Pharmaceuticals
- Zydus Pharmaceuticals
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
This text is related
to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
This text is related
to country scope.
Frequently Asked Questions
Diltiazem is a benzothiazepine derivative that acts as an antihypertensive and vasodilator. Diltiazem is an antihypertensive and vasodilator that lowers blood pressure by relaxing the vascular muscle. This is due to the long-term therapeutic effects of decreasing blood pressure since it lowers the risk of fatal and non-fatal cardiovascular events, such as strokes and myocardial infarction. According to in vitro binding experiments, diltiazem is 70%-80% bound to plasma proteins. 12 At clinically relevant concentrations, around 40% of the medication is thought to attach to alpha-1-glycoprotein, whereas about 30% of the drug is thought to bind to albumin.
The factors that are driving and restraining factors that will affect Diltiazem market in the coming years. Factors such as increase in cardiovascular disease incidence and increasing elderly population are driving the market growth. However, side effects of diltiazem is likely to hamper the growth of the market.
The Diltiazem market majorly consists of the players such as Bausch Health, Teva Pharmaceutical Industries Ltd, Mylan N.V, Athenex, Pfizer, Inc, Glenmark, Sandoz (Novartis Ag),Sun Pharmaceutical Company Ltd, Hikma Pharmaceuticals, Zydus Pharmaceuticals among others amongst others.
The US is the largest market for Diltiazem at a global level., In the United States hypertension was a primary or contributing factor in roughly half a million deaths in in recent years. Hypertension-related deaths have increased by 72 percent and 20 percent in rural and urban areas of the United States, respectively. According to Centers for Disease Control and Prevention, high blood pressure costs the United States about $131 billion each year. In the United States, heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups. According to the WHO in the United States, one person dies from cardiovascular disease every 36 seconds. Every year, over 655,000 Americans die from heart disease, accounting for one out of every four deaths.
The global diltiazem market based on product is segmented into capsules, injection, and tablets. In 2021, the tablets segment held the largest share of the market, by product type. However , the capsules segment of Diltiazem Market is also expected to witness fastest CAGR of 12.8% during 2021 to 2028. Factors such as increase in cardiovascular disease incidence and increasing elderly population are driving the market growth. However, side effects of diltiazem is likely to hamper the growth of the market.
Asia Pacific is expected to be the fastest-growing region and is likely to expand at a high growth rate due to government initiatives in drug approval process. Moreover, the rise in prevalence of cardiovascular disease such as angina, hypertension and arrythmia is likely to boost the growth of market in Asia-Pacific region. For instance, The rise in the cardiovascular diseases is observed due to the rise in the risk factors such as smoking, blood pressure, cholesterol and diabetes. The percentage of men who smoke in Japan is approximately 35.4% which is nearly double than the rate of smoking in US. The average blood pressure in Japan is nearly 130.5 and the cholesterol leverage averages approximately 201 mg/dl (5.2 mmol/L). However, the rate of diabetes is little less, compared to the rate in US. The rate of diabetes in Japan is approximately 7.2%. Owing to these factors the country is likely to demand more of the cardiovascular diagnostic and treatment devices in future.
The List of Companies - Diltiazem Market
- Bausch Health
- Teva Pharmaceutical Industries Ltd
- Mylan N.V
- Athenex
- Pfizer, Inc
- Glenmark
- Sandoz (Novartis Ag)
- Sun Pharmaceutical Company Ltd
- Hikma Pharmaceuticals
- Zydus Pharmaceuticals
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
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- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
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Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
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We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
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- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
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We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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