[Rapporto di ricerca] Il mercato della sintesi di oligonucleotidi è stato valutato a 1.584,16 milioni di dollari nel 2018 e si prevede che la dimensione del mercato della sintesi di oligonucleotidi raggiungerà 3.971,72 milioni di dollari entro il 2027. Si prevede che registrerà un CAGR dell'11,1% nel periodo di previsione.
Approfondimenti di mercato e visione degli analisti:
La sintesi di oligonucleotidi si riferisce alla sintesi di brevi frammenti di acidi nucleici utilizzando l'ingegneria genetica e la chimica degli enzimi. La tecnica è utile nella pratica di laboratorio esistente in quanto fornisce un accesso rapido ed economico a oligonucleotidi personalizzati della lunghezza e sequenza desiderate. Gli oligonucleotidi vengono utilizzati dalla ricerca iniziale e dallo screening fino alla validazione del target e alla produzione del farmaco. Oggi, i successivi miglioramenti nella sintesi, amplificazione e automazione degli oligonucleotidi hanno completamente rivoluzionato la ricerca biologica. Le crescenti applicazioni di oligonucleotidi sintetizzati, i crescenti investimenti per la biologia sintetica e i progressi tecnologici degli strumenti di editing genomico sono i principali fattori trainanti per la crescita del mercato nel periodo di previsione. Tuttavia, la crescita del mercato è frenata da fattori quali le rinnovate normative per la biotecnologia e la mancanza di professionisti qualificati nel settore delle scienze della vita.
Driver di crescita e Opportunità:
Gli oligonucleotidi hanno molte applicazioni nella ricerca, nella diagnosi delle malattie, nella terapia, nella medicina legale, nella scoperta di farmaci, nell'agricoltura e molto altro ancora. Gli oligonucleotidi sono utilizzati in molte applicazioni biologiche e forensi poiché gli agenti leganti sequenza-specifici possono aiutare a identificare la presenza di una specifica sequenza di DNA bersaglio. Gli oligonucleotidi sintetici sono brevi tratti di frammenti di DNA a filamento singolo assemblati mediante sintesi chimica. Non esiste quasi un campo della biologia in cui il DNA sintetico non sia stato utilizzato o non abbia il potenziale per essere utilizzato. La ragione principale di tale inversione di tendenza è lo sviluppo simultaneo di metodi per la sintesi rapida ed efficiente di oligonucleotidi e l'avvento di tecniche di biologia molecolare.
Gli oligonucleotidi sintetici sono ampiamente utilizzati nel diagnosi delle malattie genetiche umane. Le sonde oligonucleotidiche vengono utilizzate per rilevare cambiamenti di singole coppie di basi all'interno del genoma umano. Ad esempio, l'anemia falciforme causata da una trasversione (A^T) nel gene della β-globina può essere analizzata con oligonucleotidi marcati. In condizioni di ibridazione rigorose, è possibile rilevare se uno o due alleli della famiglia contengono il gene mutante. I ricercatori stanno anche utilizzando gli oligonucleotidi per produrre una sintesi chimica più efficiente ed ecologica. Assemblando gli oligonucleotidi in frammenti più lunghi che codificano geni sintetici, è possibile istruire batteri o cellule di lievito a produrre enzimi specifici (un tipo di proteina).
Gli oligonucleotidi hanno un enorme potenziale per il trattamento vasta gamma di condizioni mediche. Consentono lo sviluppo di terapie poiché i geni malfunzionanti possono essere presi di mira, manipolati, messi a tacere e/o modulati. Ionis Pharmaceuticals ha dedicato la propria esistenza allo sviluppo terapeutico di oligonucleotidi, in particolare di oligonucleotidi antisenso (ASO). Pertanto, il potenziale promettente degli oligonucleotidi sintetizzati in vari campi guida la crescita del mercato.
Approfondimenti strategici
Segmentazione e ambito del rapporto:
Il "mercato globale della sintesi di oligonucleotidi" ; è segmentato in base al prodotto, all'utente finale dell'applicazione e all'area geografica. Il segmento di prodotto del mercato della sintesi degli oligonucleotidi è ampiamente segmentato in oligonucleotidi, reagenti e apparecchiature sintetizzati. Il mercato della sintesi degli oligonucleotidi è classificato sulla base di applicazioni quali ricerca, diagnostica e terapeutica. Sulla base del mercato degli utenti finali è classificato in istituti di ricerca accademica, farmaceutici e industriali. aziende biotecnologiche, laboratori diagnostici e altri utenti finali. Il mercato della sintesi di oligonucleotidi in base alla geografia è segmentato in Nord America (Stati Uniti, Canada e Messico), Europa (Germania, Francia, Italia, Regno Unito, Russia e resto d’Europa), Asia Pacifico (Australia, Cina, Giappone, India, Corea del Sud e resto dell'Asia Pacifico), Medio Oriente e altri paesi. Africa (Sudafrica, Arabia Saudita, Emirati Arabi Uniti e resto del Medio Oriente e dell'Africa) e Sud e Africa. America centrale (Brasile, Argentina e resto dell'America meridionale e centrale)
Analisi segmentale:
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
This text is related
to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
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to country scope.
Frequently Asked Questions
The Asia Pacific oligonucleotide synthesis market is expected to grow at highest rate during the forecast period owing to higher number of research & development.
The major key player in oligonucleotide synthesis market are Thermo Fisher Scientific Inc., DNA Script, GenScript, Synthomics, Ansa Biotechnologies, Helixworks, Molecular Assemblies, Keasling Laboratories, Nuclera Nucleics, Camena Bioscience, Evonetix, Twist Biosciences, Iridia
Strategic acquisition and product launches were observed as the most adopted strategy in global oligonucleotide synthesis industry.
The List of Companies
- Thermo Fisher Scientific Inc.
- GenScript
- Molecular Assemblies
- Twist Biosciences
- Evonetix
- DNA Script
- Nuclera Nucleics
- Camena Bioscience
- Synthomics
- Ansa Biotechnologies
- Helixworks
- Iridia
- Keasling Laboratories
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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