寡核苷酸合成市场规模及趋势| 2027 年报告

  • Report Code : TIPBT00002549
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 174
Buy Now

[研究报告]2018年寡核苷酸合成市场价值为1,584.16百万美元,预计到2027年寡核苷酸合成市场规模将达到3,971.72百万美元。预计复合年增长率预测期内增长 11.1%。

市场洞察和分析师观点:

寡核苷酸合成是指利用基因工程和酶化学合成短的核酸片段。该技术在现有实验室实践中很有用,因为它提供了快速且廉价地获得所需长度和序列的定制寡核苷酸的方法。从最初的研究和筛选到目标验证和药物生产,都使用寡核苷酸。如今,寡核苷酸合成、扩增和自动化的后续改进彻底改变了生物学研究。合成寡核苷酸应用的增加、合成生物学投资的增加以及基因组编辑工具的技术进步是预测期内市场增长的关键驱动因素。然而,市场的增长受到生物技术法规更新以及生命科学行业缺乏熟练专业人员等因素的限制。

增长动力和机会:

寡核苷酸在研究、疾病诊断、治疗、法医学、药物发现、农业等领域有许多应用。寡核苷酸被用于许多生物学和法医学应用,因为序列特异性结合剂可以帮助识别特定目标 DNA 序列的存在。合成寡核苷酸是通过化学合成组装的短链单链 DNA 片段。生物学中几乎没有一个领域没有使用或没有使用合成DNA的潜力。造成这种转变的主要原因是寡核苷酸快速高效合成方法的同步发展和分子生物学技术的出现。

合成寡核苷酸广泛应用于人类遗传疾病的诊断。寡核苷酸探针用于检测人类基因组内的单碱基对变化。例如,由β-珠蛋白基因内的颠换(A^T)引起的镰状细胞性贫血可以用标记的寡核苷酸进行分析。在严格杂交条件下,可以检测家族的一个或两个等位基因是否含有突变基因。研究人员还利用寡核苷酸进行更高效、更环保的化学合成。通过将寡核苷酸组装成编码合成基因的较长片段,可以指示细菌或酵母细胞产生特定的酶(一种蛋白质)。

寡核苷酸在治疗疾病方面具有巨大潜力广泛的医疗条件。它们使得治疗方法的开发成为可能,因为可以靶向、操纵、沉默和/或调节故障基因。 Ionis Pharmaceuticals 致力于寡核苷酸治疗药物的开发,特别是反义寡核苷酸 (ASO) 治疗药物。因此,合成寡核苷酸在各个领域的广阔前景推动了市场的增长。

战略洞察

报告细分和范围:

“全球寡核苷酸合成市场” ;根据产品、应用程序最终用户和地理位置进行细分。寡核苷酸合成市场的产品部分大致分为合成寡核苷酸、试剂和设备。寡核苷酸合成市场根据研究、诊断和治疗等应用进行分类。根据最终用户市场分为学术研究机构、制药和医疗机构。生物技术公司、诊断实验室和其他最终用户。基于地理位置的寡核苷酸合成市场分为北美(美国、加拿大和墨西哥)、欧洲(德国、法国、意大利、英国、俄罗斯和欧洲其他地区)、亚太地区(澳大利亚、中国、日本、印度、韩国、亚太地区其他地区)、中东和美国非洲(南非、沙特阿拉伯、阿联酋以及中东和非洲其他地区)以及南美和非洲中美洲(巴西、阿根廷以及南美洲和中美洲其他地区)

细分分析:

寡核苷酸合成市场的产品部分大致分为合成寡核苷酸、试剂和设备。 Twist Bioscience、Thermo Fisher Scientific Inc. 和 Agilent Technologies 等公司是寡核苷酸合成市场的主要参与者。合成寡核苷酸是2017年寡核苷酸合成市场中最大的产品部分,预计也将在2027年占据最大的市场。除了诊断和治疗目的外,寡核苷酸还用于设计用于DNA微芯片作为纳米技术领域强大的生物分析工具和新型材料。由于合成寡核苷酸带来的好处,预计该领域的需求在预测期内将显着增长。

寡核苷酸合成市场根据应用进行分类,例如如研究、诊断和治疗。该市场由研究领域主导,预计在预测期内将大幅增长。各国对研发活动的投资预计将在预测期内推动寡核苷酸合成的需求。例如,在加拿大,展望 2018 年和 2021 年,公司的投资有所增加。预期研发支出。 2018 年和 2021 年,最大的研发支出类别约为 1 至 500 万美元。在研究领域,用于基因敲除、基因分型和诊断等目的的寡核苷酸通常在合成后需要进一步纯化。因此,研究活动的增加预计将在未来几年为寡核苷酸合成市场提供显着的增长机会。

基于学术研究机构、制药公司等最终用户&生物技术公司、诊断实验室和其他最终用户。此外,由于各个组织和大学之间的合作伙伴关系,形成了许多组织,以研究科学技术的转化,为患者提供挽救生命的治疗方法。例如,TrinSeq,即都柏林三一学院三一转化医学研究所 (TTMI) 的三一基因组测序实验室。 Trinity 基因组测序实验室拥有 Illumina MiSeq,这是用于执行超高通量基因组解决方案的基因合成平台。该设施由研究人员提供支持,爱尔兰所有学术和其他工业研究人员都可以使用这些研究人员。学术和研究经费研究机构提升寡核苷酸合成市场份额。

区域分析:

< p>根据地理位置,寡核苷酸合成市场分为五个关键区域:北美、欧洲、亚太地区、南美洲和南美洲。中美洲、中东和非洲非洲。由于制药和生物技术公司开发投资的增加、政府机构的资金以及市场数量的增加等因素,美国寡核苷酸合成市场预计在预测期内将出现显着增长寡核苷酸合成市场的参与者及其关注点。致力于制造公司以及学术和研究机构开发基于基因合成的最终产品(例如精准医学和其他疗法)的投资和资金不断增加是主要驱动因素之一。根据由投资者、企业家和其他人士组成的领先社区 SynBioBeta 发布的年度行业增长更新,美国和世界各地的多家公司在合成生物学领域的投资超过 10 亿美元。此外,根据国家生物技术信息中心(NCBI)的报告,美国政府每年为合成生物学研究和开发提供约2.2亿美元。

此外,欧洲寡核苷酸合成市场包括法国、德国、意大利、西班牙、英国和欧洲其他国家等国家。预计该地区从 2018 年到 2027 年将实现 13.7% 的稳定增长率。由于生物技术行业的不断发展、欧洲寡核苷酸合成市场的伙伴关系和合作等因素,欧洲寡核苷酸合成市场预计将在预测期内出现显着增长。市场参与者以及增加风险资本投资。此外,英国寡核苷酸合成市场的参与者一直在获得资金以增强其产品供应。例如,2019 年 3 月,英国私营生物技术公司 Procarta Biosystems 从 Novo Holdings REPAIR Impact Fund 获得了 169 万美元(150 万欧元)的资金,以开发对抗抗菌药物的新疗法电阻(AMR)。这笔资金将用于通过 Procarta 独家的基于寡核苷酸的抗菌平台开发一系列新型抗生素精准药物。上述因素预计将在预测期内大幅推动英国寡核苷酸合成市场的增长。

亚太地区包括印度、中国、日本等国家、澳大利亚、韩国和亚太其他地区。由于日本和中国等国家生物技术产业的发展、癌症的流行以及亚洲市场公司的战略发展,预计这些国家的寡核苷酸合成市场将会增长。上述因素在预测期内为寡核苷酸合成市场提供了巨大的增长机会。此外,中国政府正在加大对基因研究的支持,并得到本土企业的支持。中国的遗传学研究蓬勃发展,对基因测序的需求不断增加。除了本地企业外,国际企业也在该国投资。例如,Illumina 公司扩大了在中国的业务,并将总部迁至上海。该公司还在中国推出了 BaseSpace Sequence Hub。 Illumina, Inc. 的这款扩展仪器正在协助广泛的基因组研究。该仪器能够使用一组精选的分析应用程序来管理和分析数据,并且包括基于云的基因组学数据存储解决方案。

行业发展和未来机遇:

主要参与者采取的各种举措全球寡核苷酸合成市场如下:

  1. 2022年7月,药明康德旗下合全药业在常州基地推出了全新的大型寡核苷酸合成产品。规模寡核苷酸和肽生产工厂。通过这一新产品的推出,它将能够更好地满足全球对寡核苷酸和肽疗法开发和制造快速增长的需求。
  2. 2022 年 4 月,Bachem 与礼来公司(Eli Lilly & Inc.)达成战略合作。公司开发和生产基于寡核苷酸(一种新兴的新型复杂分子)的活性药物成分。根据协议,Bachem 提供适当的工程基础设施和专业知识来实施礼来公司的新型寡核苷酸制造技术。

Covid-19 影响:

寡核苷酸合成市场受到了 COVID-19 的影响。由于全球范围内对 COVID-19 诊断的需求不断增长,对作为分子诊断解决方案基础的寡核苷酸原材料的需求也有所增加。 2022 年 3 月发表在 PLOS One 上的一项研究发现,寡核苷酸成功地靶向了冠状病毒基因组中的 5'-polyU。此外,可以通过创建治疗性新冠病毒来减少新 SARS-CoV-2 的产生和传播-19 使用关键突变位点(例如 5'-polyU 链)的药物。此类研究影响了药物开发中寡核苷酸的需求和使用,这对大流行期间的市场扩张产生了影响。此外,许多企业正在投资寡核苷酸合成,预计这将在整个预期期间加速市场扩张。例如,SpeeDx 于 2021 年 9 月对当地寡核苷酸制造进行了投资,以降低供应链风险并为重要诊断提供更重要的主权能力。由于这些突破,寡核苷酸预计将更频繁地用于药品生产,这可能会在未来几年推动市场扩张。

竞争格局和主要公司:

全球寡核苷酸合成市场的一些知名企业 Molecular Assemblies、Twist Bioscience、Evonetix 、Nuclera Nucleics Ltd.、Camena Bio、DNA Script、Iridia, Inc.、Helixworks、Ansa Biotechnologies, Inc. 和 Synthomics, Inc. 等。这些寡核苷酸公司专注于新产品的推出和地域扩张,以满足全球不断增长的消费者需求,并增加其专业产品组合的产品范围。他们在全球范围内拥有广泛的业务,这使他们能够为大量客户提供服务,从而增加他们的市场份额。该报告提供了寡核苷酸合成市场的趋势分析,重点关注各种参数,例如技术进步、市场动态以及全球领先市场参与者的竞争格局分析。

Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

This text is related
to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

This text is related
to country scope.

Frequently Asked Questions


Which region is projected to be the fastest growing region in the global oligonucleotide synthesis market?

The Asia Pacific oligonucleotide synthesis market is expected to grow at highest rate during the forecast period owing to higher number of research & development.

Who are the key players in the oligonucleotide synthesis market?

The major key player in oligonucleotide synthesis market are Thermo Fisher Scientific Inc., DNA Script, GenScript, Synthomics, Ansa Biotechnologies, Helixworks, Molecular Assemblies, Keasling Laboratories, Nuclera Nucleics, Camena Bioscience, Evonetix, Twist Biosciences, Iridia

What are the key growth strategies of oligonucleotide synthesis market players?

Strategic acquisition and product launches were observed as the most adopted strategy in global oligonucleotide synthesis industry.

The List of Companies

  1. Thermo Fisher Scientific Inc.
  2. GenScript
  3. Molecular Assemblies
  4. Twist Biosciences
  5. Evonetix
  6. DNA Script
  7. Nuclera Nucleics
  8. Camena Bioscience
  9. Synthomics
  10. Ansa Biotechnologies
  11. Helixworks
  12. Iridia
  13. Keasling Laboratories

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

Your data will never be shared with third parties, however, we may send you information from time to time about our products that may be of interest to you. By submitting your details, you agree to be contacted by us. You may contact us at any time to opt-out.

Related Reports