The anticoagulant reversal drug market in North America is expected to grow from US$ 414.7 million in 2019 to US$ 1,037.9 million by 2027; it is estimated to grow at a CAGR of 12.8% from 2019 to 2027.
The US, Canada, and Mexico are major economies in North America. Oral anticoagulants are widely used and are highly effective in preventing thromboembolism among AFib patients. However, the use of anticoagulants may lead to bleeding in AFib patients; thus, anticoagulant reversal drugs are used to prevent bleeding. As per the Centers for Disease Control and Prevention (CDC), in 2018, in the US, AFib was mentioned on around 175,326 death certificates and was the primary cause of death in about 25,845 of those deaths. Additionally, it has also anticipated that 12.1 million people in the US will have AFib by 2030.
According to the report "Beyond the Burden: The Impact of Atrial Fibrillation in Asia Pacific," from Biosense Webster (part of Johnson & Johnson Medical Devices Companies), atrial fibrillation is projected to affect around 72 million people by 2050. Thus, such high prevalence of atrial fibrillation is likely to favor the growth of the market.
With the new features and technologies, vendors can attract new customers and expand their footprints in emerging markets. This factor is likely to drive the anticoagulant reversal drugs market. The North America anticoagulant reversal drugs market is expected to grow at a good CAGR during the forecast period.
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North America Anticoagulant Reversal Drug Market Segmentation
By Product
- Prothrombin Complex Concentrates
- Vitamin K
- Protamine
- Tranexamic Acid
- Idarucizumab
- AndeXXa
By Distribution Channel
- Hospital Pharmacies
- Retail Pharmacies
- Others
By Country
North America
- US
- Canada
- Mexico
Companies Mentioned
- Boehringer Ingelheim International GmbH
- Pfizer Inc
- Octapharma AG
- AMAG PHARMACEUTICALS, INC.
- Fresenius Kabi AG
- Alexion Pharmaceuticals, Inc. (Portola Pharmaceuticals)
- CSL Limited
- Grifols, S.A.

Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Product, End User

Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
US, Canada
1. Introduction
1.1 Scope of the Study
1.2 The Insight Partners Research Report Guidance
1.3 Market Segmentation
1.3.1 Anticoagulant Reversal Drug Market – By Product
1.3.2 Anticoagulant Reversal Drug Market – By Distribution Channel
1.3.3 North America Anticoagulant Reversal Drug Market – By Country
2. North America Anticoagulant Reversal Drug Market – Key Takeaways
3. Research Methodology
3.1 Coverage
3.2 Secondary Research
3.3 Primary Research
4. North America Anticoagulant Reversal Drug Market – Market Landscape
4.1 Overview
4.2 PEST Analysis
4.2.1 Anticoagulant Reversal Drug Market- North America PEST Analysis
4.3 Expert Opinion
5. North America Anticoagulant Reversal Drug Market - Key Market Dynamics
5.1 Market Drivers
5.1.1 Rise in Prevalence of Atrial Fibrillation (AFib)
5.1.2 Increase in Prevalence of Stroke
5.2 Market Restraints
5.2.1 High Cost of Anticoagulant Reversal Drugs
5.3 Market Opportunities
5.3.1 Increasing Research Activities on Anticoagulant Reversal Drugs
5.4 Future Trends
5.4.1 Development and Launch of Innovative Products
5.5 Impact Analysis
6. Anticoagulant Reversal Drug Market – North America Analysis
6.1 North America Anticoagulant Reversal Drug Market Revenue Forecasts and Analysis
7. North America Anticoagulant Reversal Drug Market Analysis and Forecasts To 2027 – By Product
7.1 Overview
7.2 Anticoagulant Reversal Drugs Market Share, by Product, 2019 and 2027 (%)
7.3 Prothrombin Complex Concentrates
7.3.1 Overview
7.3.2 Prothrombin Complex Concentrates: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
7.4 Vitamin K
7.4.1 Overview
7.4.2 Vitamin K: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
7.5 Protamine
7.5.1 Overview
7.5.2 Protamine: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
7.6 Tranexamic Acid
7.6.1 Overview
7.6.2 Tranexamic Acid: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
7.7 Idarucizumab
7.7.1 Overview
7.7.2 Idarucizumab: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
7.8 Andexxa
7.8.1 Overview
7.8.2 Andexxa: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
8. North America Anticoagulant Reversal Drug Market Analysis and Forecasts to 2027– By Distribution Channel
8.1 Overview
8.2 Anticoagulant Reversal Drugs Market Share, by Distribution Channel, 2019 and 2027 (%)
8.3 Hospital Pharmacies
8.3.1 Overview
8.3.2 Hospital Pharmacies: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
8.4 Retail Pharmacies
8.4.1 Overview
8.4.2 Retail Pharmacies: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
8.5 Others
8.5.1 Overview
8.5.2 Others: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
9. Anticoagulant Reversal Drug Market Revenue and Forecasts to 2027 – Geographical Analysis
9.1 North America: Anticoagulant Reversal Drugs Market
9.1.1 Overview
9.1.2 North America: Anticoagulant Reversal Drugs Market, by Country, 2019 & 2027 (%)
9.1.3 US: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
9.1.3.1 US: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
9.1.3.2 US: Anticoagulant Reversal Drugs Market, by Product, 2018–2027 (USD Million)
9.1.3.3 US: Anticoagulant Reversal Drugs Market, by Distribution Channel 2018–2027 (USD Million)
9.1.4 Canada: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
9.1.4.1 Canada: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
9.1.4.2 Canada: Anticoagulant Reversal Drugs Market, by Product, 2018–2027 (USD Million)
9.1.4.3 Canada: Anticoagulant Reversal Drugs Market, by Distribution Channel 2018–2027 (USD Million)
9.1.5 Mexico: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
9.1.5.1 Mexico: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
9.1.5.2 Mexico: Anticoagulant Reversal Drugs Market, by Product, 2018–2027 (USD Million)
9.1.5.3 Mexico: Anticoagulant Reversal Drugs Market, by Distribution Channel 2018–2027 (USD Million)
10. Impact Of COVID-19 Pandemic on North America Anticoagulant Reversal Drug Market
10.1 North America: Impact Assessment of COVID-19 Pandemic
11. Industry Landscape
11.1 Overview
11.2 Organic Developments
11.2.1 Overview
11.2.2 Organic Developments Done By Companies
11.3 Inorganic Developments
11.3.1 Overview
11.3.2 Inorganic Developments Done By Companies
Source: The Insight Partners Analysis, Website, Press Releases and Others
12. COMPANY PROFILES
12.1 Boehringer Ingelheim International GmbH
12.1.1 Key Facts
12.1.2 Business Description
12.1.3 Products and Services
12.1.4 Financial Overview
12.1.5 SWOT Analysis
12.1.6 Key Developments
12.2 Pfizer Inc.
12.2.1 Key Facts
12.2.2 Business Description
12.2.3 Products and Services
12.2.4 Financial Overview
12.2.5 SWOT Analysis
12.2.6 Key Developments
12.3 Octapharma AG
12.3.1 Key Facts
12.3.2 Business Description
12.3.3 Products and Services
12.3.4 Financial Overview
12.3.5 SWOT Analysis
12.3.6 Key Developments
12.4 AMAG PHARMACEUTICALS, INC.
12.4.1 Key Facts
12.4.2 Business Description
12.4.3 Products and Services
12.4.4 Financial Overview
12.4.5 SWOT Analysis
12.4.6 Key Developments
12.5 Fresenius Kabi AG
12.5.1 Key Facts
12.5.2 Business Description
12.5.3 Products and Services
12.5.4 Financial Overview
12.5.5 SWOT Analysis
12.5.6 Key Developments
12.6 Alexion Pharmaceuticals, Inc. (Portola Pharmaceuticals)
12.6.1 Key Facts
12.6.2 Business Description
12.6.3 Products and Services
12.6.4 Financial Overview
12.6.5 SWOT Analysis
12.6.6 Key Developments
12.7 CSL Limited
12.7.1 Key Facts
12.7.2 Business Description
12.7.3 Products and Services
12.7.4 Financial Overview
12.7.5 SWOT Analysis
12.7.6 Key Developments
12.8 Grifols, S.A.
12.8.1 Key Facts
12.8.2 Business Description
12.8.3 Products and Services
12.8.4 Financial Overview
12.8.5 SWOT Analysis
12.8.6 Key Developments
13. Appendix
13.1 About the Insight Partners
13.2 Glossary of Terms
LIST OF TABLES
Table 1. US Anticoagulant Reversal Drugs Market, by Product – Revenue and Forecast to 2027 (USD Million)
Table 2. US Anticoagulant Reversal Drugs Market, by Distribution Channel – Revenue and Forecast to 2027 (USD Million)
Table 3. Canada Anticoagulant Reversal Drugs Market, by Product – Revenue and Forecast to 2027 (USD Million)
Table 4. Canada Anticoagulant Reversal Drugs Market, by Distribution Channel – Revenue and Forecast to 2027 (USD Million)
Table 5. Mexico Anticoagulant Reversal Drugs Market, by Product – Revenue and Forecast to 2027 (USD Million)
Table 6. Mexico Anticoagulant Reversal Drugs Market, by Distribution Channel – Revenue and Forecast to 2027 (USD Million)
Table 7. Glossary of Terms, Anticoagulant Reversal Drug Market
LIST OF FIGURES
Figure 1. Anticoagulant Reversal Drug Market Segmentation
Figure 2. North America Anticoagulant Reversal Drug Market Overview
Figure 3. Vitamin K Segment Held Largest Share of Product in Anticoagulant Reversal Drug Market
Figure 4. Hospital Pharmacies Segment Held Largest Share of Distribution Channel in Anticoagulant Reversal Drug Market
Figure 5. US is Expected to Show Remarkable Growth During the Forecast Period
Figure 6. Anticoagulant Reversal Drug Market - North America PEST Analysis
Figure 7. Anticoagulant Reversal Drug Market Impact Analysis of Driver and Restraints
Figure 8. North America Anticoagulant Reversal Drug Market – Revenue Forecasts and Analysis – 2019- 2027
Figure 1. Anticoagulant Reversal Drugs Market Share, by Product, 2019 and 2027 (%)
Figure 2. Prothrombin Complex Concentrates: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 3. Vitamin K: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 4. Protamine: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 5. Tranexamic Acid: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 6. Idarucizumab: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 7. Andexxa: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 8. Anticoagulant Reversal Drugs Market Share, by Distribution Channel, 2019 and 2027 (%)
Figure 9. Hospital Pharmacies: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 10. Retail Pharmacies: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 11. Others: Anticoagulant Reversal Drugs Market– Revenue and Forecast to 2027 (USD Million)
Figure 12. North America: Anticoagulant Reversal Drugs Market, by Key Country – Revenue (2019) (USD Million)
Figure 13. North America: Anticoagulant Reversal Drugs Market, by Country, 2019 & 2027 (%)
Figure 14. US: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
Figure 15. Canada: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
Figure 16. Mexico: Anticoagulant Reversal Drugs Market – Revenue and Forecast to 2027 (USD Million)
Figure 17. Impact of COVID-19 Pandemic in North American Country Markets
Figure 18. Growth Strategies Done by the Companies in the Market, (%)
- Boehringer Ingelheim International GmbH
- Pfizer Inc
- Octapharma AG
- AMAG PHARMACEUTICALS, INC.
- Fresenius Kabi AG
- Alexion Pharmaceuticals, Inc. (Portola Pharmaceuticals)
- CSL Limited
- Grifols, S.A.
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- 3.1 Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- 3.2 Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- 3.3 Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- 3.4 Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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