[Informe de investigación] El mercado de desarrollo de líneas celulares se valoró en 4.160,42 millones de dólares en 2019 y se prevé que alcance los 11.219,87 millones de dólares en 2027; se espera que crezca a una tasa compuesta anual del 13,3 % entre 2020 y 2027.
Perspectivas del mercado y visión del analista:
El desarrollo de líneas celulares es el proceso mediante el cual se utiliza la maquinaria celular para fabricar productos biológicos terapéuticos u otras proteínas de interés. La línea celular es un cultivo celular establecido donde las células se multiplican en el medio de crecimiento y espacio apropiados para el crecimiento. Las líneas celulares permiten alteraciones graduales en la estructura, fisiología y estructura genética de las células en un entorno personalizado. Se espera que las crecientes inversiones en investigación y desarrollo por parte de las empresas farmacéuticas y biotecnológicas, junto con la creciente adopción de medicamentos regenerativos, impulsen el crecimiento del mercado de desarrollo de líneas celulares durante el período previsto.
Impulsores de crecimiento y desafíos:
En los últimos años, los casos de cáncer han aumentado enormemente y la tendencia es Se prevé que seguirá siendo el mismo en los próximos años. Los cambios en el estilo de vida han resultado en una mayor exposición a factores oncogénicos. El cáncer es una de las principales causas de muerte a nivel mundial y está afectando profundamente la calidad de vida. Según las estadísticas de 2020 de la Organización Mundial de la Salud, aproximadamente 10 millones de muertes en todo el mundo se debieron al cáncer. Por ejemplo, según la Sociedad Estadounidense del Cáncer, en 2020 se espera que se detecten 1,8 millones de nuevos casos de cáncer y 606.520 muertes por cáncer en los EE. UU. El cáncer se puede curar si se diagnostica y trata en una etapa inicial. La secuenciación del cáncer mediante métodos de secuenciación de próxima generación (NGS) proporciona más información. Además, el desarrollo de líneas celulares también ayuda en la investigación, el diagnóstico y el tratamiento del cáncer.
La creciente participación de varias CDMO en el mercado de desarrollo de líneas celulares está impulsando la tasa de crecimiento del mercado. Por ejemplo, ABC Biologics fue nombrado innovador líder en el desarrollo de líneas celulares de mamíferos para EE. UU. en 2022, lo que respalda el crecimiento del mercado de desarrollo de líneas celulares.
Sino Biological es una organización de investigación por contrato ( CRO) especializada en la producción recombinante de proteínas y anticuerpos, con proyectos rutinarios de alto rendimiento de hasta 1000 por lote. De manera similar, Aragen Bioscience, Inc, una organización líder en investigación por contrato preclínica, presentó los servicios RapTr. Los servicios de desarrollo de líneas celulares RapTr combinan la combinación probada de vectores y líneas celulares huésped CHO-DG44 con un innovador proceso de selección de clones. Un gran número de empresas CRO de desarrollo de líneas celulares ofrecen servicios de desarrollo de líneas celulares, impulsando así el crecimiento del mercado.
Por lo tanto, se espera que los factores mencionados anteriormente impulsen el mercado de desarrollo de líneas celulares.< /span>
Perspectivas estratégicas
Informe Segmentación y alcance:
El “Mercado Global de Desarrollo de Líneas Celulares” está segmentado según el tipo, producto, aplicación y geografía. Según el tipo, el mercado de desarrollo de líneas celulares se segmenta en líneas celulares primarias, hibridomas, líneas celulares continuas y líneas celulares recombinantes. Según el producto, el mercado de desarrollo de líneas celulares se segmenta en equipos, medios y reactivos. Según la aplicación, el mercado de desarrollo de líneas celulares se segmenta en descubrimiento de fármacos, bioproducción e ingeniería de tejidos. El mercado de desarrollo de líneas celulares según la geografía está segmentado en América del Norte (EE. UU., Canadá y México), Europa (Alemania, Francia, Italia, Reino Unido, Rusia y resto de Europa), Asia Pacífico (Australia, China, Japón, India). , Corea del Sur y resto de Asia Pacífico), Oriente Medio y Asia. África (Sudáfrica, Arabia Saudita, Emiratos Árabes Unidos y resto de Medio Oriente y África) y Sur y África. Centroamérica (Brasil, Argentina y resto de Centro y Suramérica)
Análisis segmentario:
En julio de 2022, ProBioGen y Granite Bio colaboraron para proporcionar servicios de desarrollo de líneas celulares y fabricación GMP. Un nuevo anticuerpo monoclonal desarrollado por Granite Bio es el principal candidato de la compañía para el tratamiento de indicaciones de cáncer autoinmunes y específicas, mediante el uso de la transposasa DirectedLuck.Impacto de Covid-19:  ;
Según el estudio titulado "Los científicos desarrollan una línea celular humana adecuada para la detección de fármacos anti-SARS-CoV-2" publicado en la revista Journal Viruses En junio de 2022, los investigadores describieron la creación de una línea celular humana adecuada para las pruebas de alto rendimiento de medicamentos antivirales dirigidos al coronavirus 2 que causa el síndrome respiratorio agudo severo (SARS-CoV-2). La enzima convertidora de angiotensina 2 (ACE2) y la serina proteasa transmembrana 2 (TMPRSS2), dos proteínas esenciales del huésped necesarias para la entrada viral, se diseñaron para expresar niveles elevados en la línea celular A549 del carcinoma de pulmón humano. Como resultado, se desarrolló más líneas celulares para controlar el COVID-19, lo que tuvo un impacto significativo en el mercado de desarrollo de líneas celulares durante la pandemia.
Panorama competitivo y empresas clave:
Algunos de los actores destacados que operan en el mercado mundial de desarrollo de líneas celulares incluyen Thermo Fisher Scientific Inc., Merck KGaA, Selexis. SA (JSR Corporation), BioFactura, Inc., Corning Incorporated, Sartorius AG, Lonza, GENERAL ELECTRIC, LakePharma, Inc. y WuXi AppTec Group entre otros. Estas empresas se centran en lanzamientos de nuevos productos y expansiones geográficas para satisfacer la creciente demanda de los consumidores en todo el mundo y aumentar su gama de productos en carteras especializadas. Tienen una amplia presencia global, lo que les permite atender a un gran conjunto de clientes y, posteriormente, aumentar su participación en el mercado de desarrollo de líneas celulares.
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
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to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
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Frequently Asked Questions
The cell line development market majorly consists of the players such as Merck KGaA, Thermo Fisher Scientific Inc., Selexis SA (JSR Corporation), BioFactura, Inc., Corning Incorporated, Sartorius AG, Lonza, GENERAL ELECTRIC, LakePharma, Inc., and WuXi AppTec Group amongst others.
The cell line is established cell culture, which gets increased numerous times when supplied with the growth medium and space for growth. Different cell lines can be made from different cells. The cell line plays a vital role in the study of cytology. The cell line enables stepwise alterations in the structure, physiology, and genetic makeup of cells under a customized environment.
The factors that are driving growth of the market are Increasing adoption of regenerative medicines, rising prevalence of cancer across the globe and increasing investments in R&D by pharmaceutical and biotechnology companies. Moreover, consistent research in drug discovery activities are offering lucrative opportunities for the growth of the market.
The List of Companies - Cell Line Development Market
- Thermo Fisher Scientific Inc.
- Merck KGaA
- Selexis SA (JSR Corporation)
- BioFactura, Inc.
- Corning Incorporated
- Sartorius AG
- Lonza
- GENERAL ELECTRIC
- LakePharma, Inc.
- WuXi AppTec Group
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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