2027年细胞系开发市场统计报告

  • Report Code : TIPHE100001196
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 181
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[研究报告]2019年细胞系开发市场价值为416,042万美元,预计到2027年将达到1121,987万美元;预计 2020 年至 2027 年复合年增长率为 13.3%。

市场洞察和分析师观点:

细胞系开发是选择细胞机器来制造治疗性生物制剂或其他感兴趣的蛋白质的过程。细胞系是一种已建立的细胞培养物,其中细胞在适当的生长培养基和生长空间中繁殖。细胞系允许在定制的环境下逐渐改变细胞的结构、生理学和遗传结构。制药和生物技术公司对研发的投资不断增加,加上再生药物的日益采用,预计将在预测期内推动细胞系开发市场的增长。

增长动力与挑战:

近年来,癌症病例急剧增加,趋势是预计未来几年将保持不变。生活方式的改变导致更多地接触致癌因素。癌症是全球主要死亡原因之一,并深刻影响生活质量。根据世界卫生组织2020年的统计,全球约有1000万人死于癌症。例如,根据美国癌症协会的数据,2020 年,美国预计将新发现 180 万癌症病例,并有 606,520 人因癌症死亡。如果在初始阶段诊断和治疗,癌症是可以治愈的。使用下一代测序 (NGS) 方法进行的癌症测序可提供更多信息。此外,细胞系开发还有助于癌症的研究、诊断和治疗。

多家 CDMO 越来越多地参与细胞系开发市场,正在推动市场的增长率。例如,ABC Biologics 被评为 2022 年美国哺乳动物细胞系开发领先创新者,支持细胞系开发市场的增长。

Sino Biologics 是一家合同研究机构( CRO)专门从事蛋白质和抗体的重组生产,常规高通量项目高达每批次1,000个。同样,领先的临床前合同研究组织 Aragen Bioscience, Inc 也推出了 RapTr 服务。 RapTr 细胞系开发服务将经过验证的 CHO-DG44 宿主细胞系和载体组合与创新的克隆选择过程相结合。多家细胞系开发CRO公司正在提供细胞系开发服务,从而推动市场增长。

因此,上述因素预计将推动细胞系开发市场的发展。< /span>

战略洞察

报告细分和范围:

“全球细胞系开发市场”根据类型、产品、应用和地理位置进行细分。根据类型,细胞系开发市场分为原代细胞系、杂交瘤、连续细胞系和重组细胞系。根据产品,细胞系开发市场分为设备、培养基和试剂。根据应用,细胞系开发市场分为药物发现、生物生产和组织工程。基于地理位置的细胞系开发市场分为北美(美国、加拿大和墨西哥)、欧洲(德国、法国、意大利、英国、俄罗斯和欧洲其他地区)、亚太地区(澳大利亚、中国、日本、印度) 、韩国和亚太地区其他地区)、中东和美国非洲(南非、沙特阿拉伯、阿联酋以及中东和非洲其他地区)以及南美和非洲中美洲(巴西、阿根廷以及南美洲和中美洲其他地区)

细分分析:

根据类型,细胞系开发市场分为原代细胞系、杂交瘤细胞、连续细胞系和重组细胞系。重组细胞系细分市场占据最大份额。此外,预计杂交瘤领域在预测期内的复合年增长率将达到 14.1%,为市场最高。重组细胞系是用于生产治疗性重组蛋白的优选系统。重组哺乳动物细胞系最常用于生产重组蛋白,因为其代谢和蛋白质加工途径与人类细胞相似。生物治疗蛋白已用于治疗各种病症,如传染病、自身免疫性疾病、激素失调、血液疾病、癌症和遗传性疾病。因此,在预测期内,越来越多地采用重组细胞系来生产生物治疗性重组蛋白,这可能会增加重组细胞系的需求。

细胞系开发市场,按类型划分 – 2019年和2027年

根据产品,细胞系开发市场分为设备、培养基和试剂。 2019年,基于培养基和试剂的细分市场占据了最大的市场份额。此外,预计同一细分市场在预测期内的复合年增长率也将达到 13.8%,为市场最高。生长培养基/培养基是在体外条件下支持细胞生长的液体或凝胶。培养基含有关键成分,例如能量来源和调节细胞周期的化合物。由于培养基和试剂是细胞系开发过程的重要组成部分,因此培养基和试剂市场在预测期内可能会出现快速增长。

根据应用情况,细胞系开发市场分为药物发现、生物生产和组织工程。 2019年,生物生产领域占据最大的市场份额。然而,在预测期内,药物发现领域的复合年增长率预计将达到 14.3%,为市场最高。细胞系是产生具有翻译后修饰的重组、大型、复杂蛋白质的首选表达系统。中国仓鼠卵巢(CHO)细胞系是用于生产重组蛋白的最常见的哺乳动物细胞系。许多市场参与者正在提供用于生物生产的细胞系。例如,Creative Biogene 提供用于生成生物生产稳定细胞系的综合服务。 Creative Biogene 在开发生物生产细胞系方面拥有丰富的经验,包括强大的载体设计和构建、基因合成、高效基因传递以及严格的 Q&C 系统等。同样,由于大量的基因组研究和开发活动,生物治疗细胞系的开发已达到了新的境界。此外,生物治疗细胞系开发中的现有技术和新兴技术在推动细胞开发市场迈向新领域方面发挥了不可或缺的作用。

区域分析:

根据地理位置,细胞系开发市场分为五个关键区域:北美、欧洲、亚太地区、南美洲和南美洲。中美洲、中东和非洲非洲。基于三个主要国家对北美细胞系开发市场进行了分析——美国、加拿大和墨西哥。据估计,在预测期内,美国将占据最大的细胞系开发市场份额。美国细胞系开发市场的增长归因于各个市场参与者,该地区已经建立的动态场景改变了该地区细胞系开发的动态。北美增长的特点是生物制药和生物技术公司对创新产品的需求增加、主要市场参与者的存在以及各个学术和研究机构进行的广泛研究和开发。此外,越来越多地关注医疗保健、政府和私人倡议中先进方法的整合,以促进精准医学,以及政府和私人机构为基因组研究提供的大量资金,预计将进一步刺激增长并为细胞系开发市场带来非凡的收入在北美。由于各种开发计划和商业策略,通过生物工程方法帮助生产、发现或改变各种生物分子和有机体,医学生物技术经历了革命。生物技术创业革命还协助促进了该国拥有前景和创新理念的新企业的发展,并支持最大限度地增加收入,从而提高北美在全球细胞系开发市场中的经济地位。

此外,各种用于细胞系开发的技术先进产品的推出预计将促进市场增长。例如,2021年10月,BICO公司推出了CYTENA,一个用于全自动稳定细胞系开发的新平台。该平台结合了 CYTENA 一流的液体处理专业知识,可实现经济高效且卓越的实验室自动化。抗体疗法、基因疗法和生物仿制药生产等下一代医疗保健解决方案生产的民主化进一步推动了 BICO 的生物融合议程。

欧洲是第二个全球细胞开发市场的领先地区。由于政府和私人对生物技术研究的资助、细胞系合成创新技术的推出以及各种新技术研究的增加等因素,德国在预测期内在欧洲细胞系开发市场中占据最大份额基于应用程序可能是推动该地区市场增长的重要因素。

行业发展和未来机遇:

行业发展和未来机遇:

全球细胞系开发市场主要参与者采取的各种举措如下:

    < li>2022 年 7 月,ProBioGen 与 Granite Bio 合作提供 GMP 制造和细胞系开发服务。 Granite Bio 开发的新型单克隆抗体是该公司使用 DirectedLuck 转座酶治疗自身免疫和特定癌症适应症的首选候选药物。
  1. 2022 年 6 月,富士胶片公司投资 16 亿美元增强和扩大 FUJIFILM Diosynth Biotechnologies(FUJIFILM Corporation 的子公司)和世界领先的合同开发和制造组织 (CDMO) 的细胞培养制造服务。这项投资还将扩大 FUJIFILM Diosynth Biotechnologies 的细胞培养制造解决方案。德克萨斯州网站。 FUJIFILM Diosynth Biotechnologies 将实施其专有的 SymphonX 生产设备,从而在一次性细胞培养物生产现场实现 cGMP MaruX 连续处理。
  2. 2019 年 4 月,Lonza 推出了 CellBio Services,这是一个全面的独特产品组合。 ,旨在满足特定的、个性化研究应用需求的定制解决方案。
  3. 2019 年 6 月,Thermo Fisher Scientific 推出了用于细胞培养的 Cytomat 2 C-LiN 系列自动化培养箱。该仪器具有自动控制湿度、内置污染减少系统和其他先进功能等规格。
  4. 2019 年 10 月,默克收购了一家美国公司 FloDesign Sonics。 FloDesign Sonics 是一家独特的声学细胞处理平台开发商,该平台适用于细胞和基因治疗制造的工业化。

Covid-19 影响:  ;

根据发表在《病毒》杂志上的题为“科学家开发合适的人类细胞系用于抗 SARS-CoV-2 药物筛选”的研究2022 年 6 月,研究人员描述了如何创建合适的人类细胞系,用于高通量测试针对引起严重急性呼吸综合征 (SARS-CoV-2) 的冠状病毒 2 的抗病毒药物。血管紧张素转换酶 2 (ACE2) 和跨膜丝氨酸蛋白酶 2 (TMPRSS2) 是病毒进入所需的两种重要宿主蛋白,经过改造后可在人肺癌细胞系 A549 中高水平表达。由此开发出更多细胞系来管理 COVID-19,这对大流行期间的细胞系开发市场产生了重大影响。

竞争格局和主要公司:

全球细胞系开发市场的一些知名企业包括 Thermo Fisher Scientific Inc.、Merck KGaA、Selexis SA (JSR Corporation)、BioFactura, Inc.、Corning Incorporated、Sartorius AG、Lonza、GENERAL ELECTRIC、LakePharma, Inc. 和 WuXi AppTec Group 等。这些公司专注于新产品发布和地域扩张,以满足全球不断增长的消费者需求,并增加其专业产品组合的产品范围。他们在全球范围内拥有广泛的业务,这使他们能够为大量客户提供服务,从而增加他们的细胞系开发市场份额。

Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

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to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

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Frequently Asked Questions


Who are the major players in the Cell line development market?

The cell line development market majorly consists of the players such as Merck KGaA, Thermo Fisher Scientific Inc., Selexis SA (JSR Corporation), BioFactura, Inc., Corning Incorporated, Sartorius AG, Lonza, GENERAL ELECTRIC, LakePharma, Inc., and WuXi AppTec Group amongst others.

What is cell line development?

The cell line is established cell culture, which gets increased numerous times when supplied with the growth medium and space for growth. Different cell lines can be made from different cells. The cell line plays a vital role in the study of cytology. The cell line enables stepwise alterations in the structure, physiology, and genetic makeup of cells under a customized environment.

What are the driving factors for the cell line development market across the globe?

The factors that are driving growth of the market are Increasing adoption of regenerative medicines, rising prevalence of cancer across the globe and increasing investments in R&D by pharmaceutical and biotechnology companies. Moreover, consistent research in drug discovery activities are offering lucrative opportunities for the growth of the market.

The List of Companies - Cell Line Development Market

  1. Thermo Fisher Scientific Inc.
  2. Merck KGaA
  3. Selexis SA (JSR Corporation)
  4. BioFactura, Inc.
  5. Corning Incorporated
  6. Sartorius AG
  7. Lonza
  8. GENERAL ELECTRIC
  9. LakePharma, Inc.
  10. WuXi AppTec Group

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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