[연구보고서]효소 DNA 합성 시장은 2022년 2억4096만 달러에서 2028년 22억4488만 달러로 성장할 것으로 예상된다. 2022년부터 2028년까지 연평균 45.1%의 성장률을 기록할 것으로 추정됩니다.
효소적 DNA 합성은 DNA 합성의 잘 확립된 기술로 합성생물학, 유전공학, 치료용 항체 생산, 백신 등에 유용합니다. 설계 및 기타 고급 생물학적 절차. 또한 DNA 라이브러리를 유지 관리하고 맞춤형 DNA 분자를 합성하는 데 도움이 되는 것으로 입증되었습니다.
효소 DNA 합성 시장 통찰력
유전 질환의 확산이 효소 DNA 합성 시장 성장을 주도합니다
< p>다운 증후군, 자폐 스펙트럼 장애, 암, 당뇨병, 낭포성 섬유증 및 겸상적혈구빈혈은 일반적으로 알려진 유전 질환 중 일부입니다. Global Genes에 따르면 10,000개 이상의 다양한 유전 및 희귀 질환이 확인되었으며 약 4억 명의 사람들이 희귀 질환으로 고통 받고 있습니다. 일부 유전 질환은 출생 시 증상을 유발하는 반면, 다른 유전 질환은 시간이 지남에 따라 발생합니다. 유전병의 세계적 부담이 증가하고 있는 것으로 보입니다. 미국 의료기관인 NCBI(National Center for Biotechnology Information)에 따르면 2021년 11월 기준으로 소아 환자의 9.4%에서 유전적 장애가 확인되었으며, 이 중 44.7%가 중환자 신생아입니다. 또한 미국에서는 1,317만 명의 환자가 독특한 유전 질환을 앓고 있습니다. 질병 통제 예방 센터(CDC) 2022 보고서에 따르면 겸상적혈구병은 미국인 약 100,000명에게 영향을 미치며 아프리카계 미국인 출생 356명 중 1명꼴로 발생합니다. 전 세계적으로 또 다른 흔한 유전병인 낭포성 섬유증은 미국에서 약 30,000명의 사람들에게 영향을 미치며 매년 약 1,000건의 새로운 사례가 치료됩니다. 효소 DNA 합성은 합성 생물학, 유전 공학 및 치료용 항체 연구에 유용한 잘 확립된 DNA 합성 기술입니다. 효소 분석과 함께 DNA 합성은 더 큰 진단 가능성을 보여줍니다. 이 방법은 위험에 처한 사람들에 대한 중요한 정보를 제공하고 질병 진단 및 약물 치료에 관한 중요한 결정을 내리는 데 도움이 됩니다. 따라서 전 세계적으로 유전 질환의 유병률이 증가함에 따라 사람들은 이러한 유전적 결함을 조기에 발견해야 할 필요성을 더 잘 인식하고 있으며, 이는 효소 DNA 합성 시장의 성장을 촉진합니다.
전략적 통찰력
높은 비용과 복잡한 절차가 효소 DNA 합성 시장의 성장 방해
효소 DNA 합성 기술은 충분히 성숙되지 않았으며 널리 사용되기 전에 추가 최적화가 필요합니다. 대부분은 DNA 서열에 새로운 염기를 추가하기 위해 생물학적 시스템에서 사용되는 자연 발생 효소 말단 데옥시뉴클레오티딜 트랜스퍼라제(TdT)를 기반으로 합니다. TdT 기반 방법은 유해 폐기물 생성을 방지하므로 화학적 절차보다 개선된 방법입니다. 그러나, 이 효소의 높은 비용과 낮은 정확도는 시험관 내 DNA 합성에서의 사용을 방해합니다. TdT 효소는 너무 관대하여 필요한 것보다 더 자주 잘못된 염기를 추가합니다. 결과적으로 TdT 기반 올리고는 더 많은 시퀀스 오류가 있고 동일하거나 더 많은 합성 후 품질 관리 단계가 필요할 수 있으므로 합성 프로세스의 시간과 비용이 증가합니다. 이 효소로 작업하는 동안 과학자들은 표적 서열을 구축하기 위해 더 많은 시약을 추가해야 하며, 이는 전체 합성 프로세스의 비용을 추가로 추가합니다. TdT를 사용하여 얻은 합성 DNA의 염기당 비용은 기존 합성 유전 물질보다 훨씬 높습니다. 따라서 높은 비용과 복잡한 절차는 효소 DNA 합성 시장의 성장을 제한합니다.
제품 유형 기반 통찰력
제품 유형에 따라 효소 DNA 합성 시장은 맞춤형 DNA로 세분화됩니다. 합성 및 DNA 라이브러리 합성. DNA 라이브러리 합성 부문은 2021년에 가장 큰 시장 점유율을 차지했습니다. 또한 맞춤형 DNA 합성 부문은 예측 기간(2022~2028) 동안 가장 높은 CAGR을 기록할 것으로 예상됩니다.
효소 DNA 합성 시장, by 제품 - 2021년 및 2028년
(이미지)
응용 기반 통찰력
효소 DNA 합성 시장은 응용 프로그램을 기반으로 합성 생물학, 유전 공학, 치료 항체, 백신 설계 및 기타 응용 프로그램. 합성 생물학 부문은 2021년에 시장에서 가장 큰 점유율을 차지했습니다. 치료용 항체 응용을 위한 효소 DNA 합성 시장은 예측 기간 동안 가장 높은 CAGR로 성장할 것으로 예상됩니다.
최종 사용자 기반 통찰력
h3>
최종 사용자를 기준으로 효소 DNA 합성 시장은 학술 & 연구 기관, 생명공학 & 제약 회사, 진단 실험실 및 기타. 생명 공학 & 제약 회사 부문은 2021년에 시장에서 가장 큰 점유율을 차지했습니다. 연구 기관 부문은 예측 기간(2022~2028) 동안 시장에서 가장 높은 CAGR을 기록할 것으로 예상됩니다.
기술 기반 통찰력
기술 기반 효소 DNA 합성 시장은 SOLA, CRISPR, PCR 등으로 세분화됩니다. PCR 부문은 2021년에 가장 큰 점유율을 차지했으며 예측 기간 동안 비슷한 추세를 계속할 것으로 예상됩니다. 한편, CRISPR 부문은 예측 기간 동안 가장 높은 CAGR을 보일 것으로 예상됩니다.
효소 DNA 합성 시장 인수합병에서 회사가 두드러지게 채택하는 전략. 주요 시장 참가자의 최근 개발 내용은 다음과 같습니다.
- 2022년 4월 GenScript는 연례 Built With Biology 글로벌 컨퍼런스에서 DNA 합성을 위한 업계 최초의 최고 처리량 반도체 칩을 출시했습니다. GenScript의 독점 소형 반도체 칩 기술을 사용하여 개발된 이 고밀도 DNA 합성 칩은 840만 개의 고유한 올리고를 동시에 합성할 수 있습니다.
- 2022년 4월 Evonetix Ltd는 독점 열 제어 기술에 대한 특허 EP3551331B1을 받았습니다. DNA 합성, 유럽의 실리콘 칩 설계 및 제조. Evonetix의 IP 포트폴리오를 확장하는 것 외에도 이 특허는 벤치탑 DNA 합성 플랫폼을 개발하려는 회사 전략의 핵심 단계로 인식됩니다.
- 2022년 3월, Molecular Assemblies, Inc.는 미국 Agilent Technologies, iSelect Fund, Codexis, LYFE Capital 및 Argonautic Ventures와 같은 모든 주요 시리즈 A 투자자와 함께 새로운 투자자인 Casdin Capital의 참여로 2,580만 달러 규모의 시리즈 B 파이낸싱. 이 회사는 자금 조달 수익금을 사용하여 주요 고객 프로그램을 시작하고 회사의 독점 완전 효소 DNA 합성 기술을 조기 상용화로 발전시킬 계획입니다.
- 2021년 11월 DNA Script는 합성 DNA 및 RNA의 효소 프린팅이 가능한 차세대 프린터 개발을 지원하기 위해 국립보건원(NIH) 산하 국립인간게놈연구소(NHGRI)
회사 프로필
- Telesis Bio Inc.
- Evonetix
- Ansa Biotechnologies, Inc.
- Camena Bio
- GenScript Biotech Corp.
- Molecular Assemblie
- DNA 스크립트
- Touchlight
- Synbio 기술
- Twist Bioscience
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
This text is related
to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
This text is related
to country scope.
Frequently Asked Questions
The Asia Pacific region is expected to be the fastest-growing region in the enzymatic DNA synthesis market over the forecast period due to increasing government investment to provide healthcare facilities, growing advancements in healthcare infrastructure, greater adoption of advanced technologies, and rising healthcare spending in countries such as China, Japan, and India.
The enzymatic DNA synthesis market is expected to be valued at US$ 2,244.88 million in 2028.
The DNA library synthesis segment held the largest share of the market in 2022, owing to the various advantages offered by DNA library synthesis such as systematic, unbiased investigations such as high-throughput screening for discovery biology, directed evolution for protein engineering, and in vitro molecular optimization to generate mutant proteins with improved or novel properties. However, the custom DNA synthesis segment is estimated to register the highest CAGR in the market during the forecast period.
The enzymatic DNA synthesis market is estimated to be valued at US$ 240.96 million in 2022.
The CAGR value of the enzymatic DNA synthesis market during the forecasted period of 2022-2028 is 45.1%.
The enzymatic DNA synthesis market majorly consists of the players, such as Telesis Bio Inc, Evonetix, Ansa Biotechnologies, Inc., Camena Bio, GenScript Biotech Corp., Molecular Assemblie, DNA Script, Touchlight, Synbio Technologies, and Twist Bioscience.
The factors that are driving the growth of the enzymatic DNA synthesis market are the rising prevalence of genetic disorders and surging number of product launches. Also, the growing demand for enzymatic DNA synthesis procedures is expected to provide opportunity for the enzymatic DNA synthesis market in forecasted period.
Enzymatic DNA synthesis (EDS) offers significant advantages in terms of accessibility and convenience, changing the pace and control of iteration and innovation with less environmental impact. The enzymes involved in DNA replication act coordinated to synthesize both leading and lagging strands of DNA simultaneously at the replication fork. Purported benefits of enzymatic synthesis include the ability to avoid the use of harsh chemical substances (which often result in toxic waste) and an ever-increasing ability to produce longer and longer strands of DNA, which in turn not only leads to a "more green" form of DNA synthesis, but also some incredibly powerful new uses for the longer DNA chains (e.g., vaccines, therapeutics, and data storage).
The List of Companies - Enzymatic DNA Synthesis Market
- Telesis Bio Inc
- Evonetix
- Ansa Biotechnologies, Inc.
- Camena Bio
- GenScript Biotech Corp.
- Molecular Assemblies
- DNA Script
- Touchligh
- Synbio Technologies
- Twist Bioscience
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
Related Reports
Mar 2023
Bioprocessing Market
Size and Forecast (2021 - 2031), Global and Regional Share, Trend, and Growth Opportunity Analysis Report Coverage: By Product (Instruments, and Consumables and Accessories), Scale of Operation (Commercial Operations and Clinical Operations), Process (Downstream Bioprocess and Upstream Bioprocess), Application (Monoclonal Antibodies, Vaccines, Recombinant Protein, Cell and Gene Therapy, and Others), End User (Biopharmaceutical Companies, Contract Manufacturing Organization, and Others), and Geography (North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa)
Mar 2023
Bioproduction Market
Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Product (Biologics and Biosimilars, Vaccines, Cell and Gene Therapies, Nucleic Acid Therapeutics, and Others), Application (Rheumatoid Arthritis, Hematological Disorders, Cancer, Diabetes, Cardiovascular Diseases, and Others), Equipment (Upstream Equipment, Downstream Equipment, Bioreactors, and Consumables and Accessories), End User (Biopharmaceutical Companies, Contract Manufacturing Organizations, and Others), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America)
Mar 2023
ELISA Diagnostic Test Market
Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Adoption (Human and Veterinary), Test Type (Sandwich ELISA, Indirect ELISA, Competitive ELISA, and Multiple & Portable ELISA), Application (Autoimmune Diseases, Infectious Diseases, Cancer Diagnosis, Protein Quantification, and Others), End User (Hospitals & Diagnostic Centers, Pharmaceutical & Biotechnology Companies, Veterinary Hospitals & Diagnostic Laboratories, and Others), and Geography (North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa)
Mar 2023
Swine Diagnostics Market
Size and Forecasts (2022 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Product Type [Immunoassays Kits, PCR Kits, Hemagglutination Inhibition (HI), and Others], Sample Type (Blood, Oral Fluids, Nasal Swabs, Tissue Samples, and Others), Disease [African Swine Fever (ASF)/Classical Swine Fever (CSF), Respiratory Diseases, Porcine Circovirus, Porcine Epidemic Diarrhea, Swine Dysentery, and Others], End User (Veterinary Hospitals, Veterinary Clinics, and Other End Users), and Geography
Mar 2023
Microbial Identification Methods Market
Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Method (Genotypic, Phenotypic, and Proteotypic), Type (Bacterial Identification System, Microbial Enumeration System, Bacterial Resistance Identification Systems, Microbiology Analyzer, and Others), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and Latin America)
Mar 2023
Biopharmaceuticals Market
Forecast to 2028 - COVID-19 Impact and Global Analysis By Product Type (Monoclonal Antibodies, Recombinant Vaccines, Conventional Vaccines, Recombinant Growth Factors, Purified Proteins, Recombinant Proteins, Recombinant Hormones, Recombinant Enzymes, Cell & Gene Therapies, Cytokines/Interferon/Interleukins, and Others) and Application (Oncology, Inflammatory & Infectious Disease, Autoimmune Disorders, Metabolic Disorders, Hormonal Disorders & Growth Failure, Cardiovascular Diseases, Neurological Diseases, and Others)
Mar 2023
GMP Cell Therapy Consumables Market
Forecast to 2028 - COVID-19 Impact and Global Analysis by Product (Kits, Reagents/Molecular Biology Reagents, Growth Factors/Cytokines and Interleukins, and Others), Cell Therapy (NK Cell Therapy, Stem Cell Therapy, T-Cell Therapy, and Others), Process (Cell Collection and Characterization/Sorting and Separation, Cell Culture and Expansion/Preparation, Cryopreservation, Cell Processing and Formulation, Cell Isolation and Activation, Cell Distribution/Handling, Process Monitoring and Control/Readministration/Quality Assurance, and Others), and End Use (Clinical, Commercial, and Research)