Botulinum Toxin Market Size, Share, Report 2028

Botulinum Toxin Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Product Type (Botulinum toxin A and Botulinum toxin B), Application (Medical and Aesthetic), and End User (Speciality and Dermatology Clinics, Hospitals and Clinics, and Others)

Publication Month : Feb 2022

  • Report Code : TIPRE00027431
  • Category : Pharmaceuticals
  • Status : Published
  • No. of Pages : 197
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The botulinum toxin market is projected to reach US$ 8,977.62 million by 2028 from US$ 5,307.71 million in 2021. It is expected to grow at a CAGR of 7.8% from 2021 to 2028.  

Botulinum toxins are neurotoxins that attack nerves and cause muscle paralysis. A bacterium known as clostridium botulinum makes these neurotoxins. Healthcare providers use specific bacteria for medical injections. Injections of botulinum toxin block nerve signals to the muscle injected into it. Without a signal, the muscle cannot contract. The result is a reduction in unwanted facial lines or features. Botulinum toxin injections, such as Botox and Dysport, improve appearance by relaxing the muscles that cause wrinkles. These injections also treat migraines, hyperhidrosis, overactive bladder, and eye problems.

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Botulinum Toxin Market: Strategic Insights

botulinum-toxin-market
Market Size Value inUS$ 5,307.71 Million in 2021
Market Size Value byUS$ 8,977.62 Million by 2028
Growth rateCAGR of 7.8% from 2021 to 2028
Forecast Period2021-2028
Base Year2021
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The botulinum toxin market is analyzed on the basis of product type, application, end user, and geography. By geography, the botulinum toxin market is broadly segmented into North America, Europe, Asia Pacific, the Middle East and Africa (MEA), and South and Central America. The botulinum toxin report offers insights and in-depth analysis of the market, emphasizing parameters, such as market trends, technological advancements, and market dynamics, along with the analysis of the competitive landscape of the world's leading market players.         

Lucrative Regions for Botulinum Toxin Market

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Market Insights

Increasing Aesthetics Procedures and Use of Botulinum Toxin Drives Botulinum Toxin Market Growth

There is a significant rise in non-surgical procedures and dermal injectables across France. According to the Global Aesthetics Consensus, in 2016, ~258,438 non-surgical aesthetic procedures were performed in the country, out of which more than 101,400 were botulinum toxin (BTX) procedures. Moreover, the expansion of cosmetology clinics and the increase in the number of cosmetology practitioners are expected to drive the botulinum toxin market further in the coming years. People from countries, such as Switzerland, Romania, and Russia, visit France for aesthetic procedures due to advanced medical services available in the country.

Moreover, in Italy, every 10th patient applying for cosmetic surgery is a tourist. The Italian Association of Aesthetic Plastic Surgery (AICPE) had announced an "aesthetic alliance" with the International Society of Aesthetic Plastic Surgery (ISAPS) to develop high-quality cosmetic surgeries with enhanced patient safety. This will increase demand for botulinum toxin market.

Similarly, according to the American Society of Plastic Surgeons (ASPS), a total of 4,401,536 botulinum toxin Type A (Botox, Dysport, Xeomin) minimally-invasive cosmetic procedures were performed in the US, in which 4,136,289 were female, and 265,247 were male. In 2020, Aesthetic Neural Network (ANN) data reported total revenue of over US$ 9 billion spent on aesthetic plastic surgery. Similary, demand for botulinum toxin market will propel.

In addition, according to the American Society of Plastic Surgeons (ASPS), in 2019, the number of cosmetic procedures performed in India was 643,752. Total non-surgical procedures were 249,024, out of which botulinum toxin procedures were 70,248. Similarly, in 2019, the total number of cosmetic procedures were performed in Brazil was 2,565,675, in which total non-surgical procedures were 1,072,002—among them, botulinum toxin procedures were 507,869, leading to grow botulinum toxin market.

Therapeutic uses of BTX include treating diseases, such as chronic migraines, muscle spasticity, over-reactive bladder, and hyperhidrosis. The cosmetic and clinical application of BTX offers a comprehensive and in-depth review of aesthetic procedures and medical applications for standalone treatment, as well as combination therapy. According to ISAPS, approximately 321,702 BTX procedures were performed in Germany in 2018. Due to the increase in the geriatric population and the desire to look young, the number of BTX-based procedures being performed in Germany is rising. As per ISAPS, Germany accounts for ~4% of the total number of cosmetic procedures performed worldwide.

Moreover, there are more than 500 plastic surgeons in the UK, and the number is expected to increase in the future. Thus, with the rise in the number of aesthetic service providers, practitioners, and plastic surgeons, the number of aesthetic procedures performed in Europe is increasing, thereby boosting the demand and sales of botulinum toxin, contributing to the growth of the botulinum toxin market.

Rising Number of Non-invasive Cosmetic Procedures Contributes Significantly to Botulinum Toxin Market Growth

Cosmetic surgery and injectable BTX are among the most popular non-invasive rejuvenation procedures, and each has its unique way of improving facial aesthetics. In 2020, the BTX treatment was the leading non-invasive cosmetic procedure performed in Europe. Furthermore, in the last decade, a facial rejuvenation procedure was popular among different types of traditional surgeries in the region. The use of BTX Type A (BoNTA) in cosmetic facial treatments helps improve the aesthetics of the upper and lower face. Thus, the increasing popularity of non-invasive cosmetic procedures is triggering the demand for botulinum toxin in Europe.

According to the American Society of Plastic Surgeons (ASPS), Non-surgical Procedures, by Country in 2019

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Source: The Insight Partners Analysis, Primary Interviews, Magazines and Journals, and Secondary Sources

Non-invasive cosmetic treatments have gained popularity in recent years due to minimal downtime, no scarring, low cost, greater accuracy, and fewer complications compared to open procedures. In addition, non-invasive treatments are gaining importance due to lower post-treatment downtime. European countries are taking several initiatives to raise awareness about non-invasive aesthetic procedures. For instance, in 2019, government authorities in England launched a campaign about botched cosmetic procedures and their impact on a person's physical and mental health. Moreover, several manufacturers are working on offering more advanced non-invasive cosmetic treatment products. Therefore, the rising awareness about non-invasive cosmetic procedures and the increasing availability of user-friendly and technologically advanced non-invasive cosmetic treatment products are boosting the growth of the European botulinum toxin market.

Product Type Insights             

Based on product type, the global botulinum toxin market is segmented into type A botulinum toxin and type B botulinum toxin. In 2020, the type A botulinum toxin segment held the largest share of the botulinum toxin market. Moreover, the market for the type A botulinum toxin segment is expected to grow at the highest CAGR during the period from 2021 to 2028. With a wide range of uses and a favorable safety profile, botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperfections, muscle spasms, and other conditions. There are many uses for botulinum toxin A in treating dystonia, incontinence, migraine, blepharospasm, and hyperhidrosis. Depending on the preparation, botulinum toxin A is indicated for different diseases. Cosmetically, it treats fine lines and wrinkles on the face, particularly wrinkles on the upper face, including the forehead, side corners of the eyes, and glabellar lines.   

Application Insights

Based on application, the botulinum toxin market is segmented into medical and aesthetics. The medical segment is sub-segmented as chronic migraine, muscle spasm, over-reactive bladder, hyperhidrosis, and others. The aesthetics segment is sub-segmented as Frown Lines/ Glabellar, Forehead Lines, Crow's Feet, Square Jaw/ Masseter, and Others.

The medical segment held the largest market share in 2020, and it is further expected to be the largest shareholder in the botulinum toxin market by 2028. Botulinum toxin is a drug used to treat and manage a variety of therapeutic conditions. Chronic migraine, spastic disorders, cervical dystonia, and detrusor hyperactivity are all examples of medicinal usage. The surge in demand for the neurotoxin class of medications is bolstering this segment's market.

End-use Insights

Based on end user, the botulinum toxin market is segmented into specialty and dermatology clinics, hospitals and clinics, and others. The specialty and dermatology clinics segment held the largest market share in 2020, and it is further expected to be the largest shareholder in the market by 2028. Minimally invasive techniques have grown in popularity even faster than surgical procedures. Botulinum toxin (botox) injections, hyaluronic acid treatments, laser hair removal, non-surgical fat reduction, and photorejuvenation (IPL) were the five most common non-surgical cosmetic procedures in 2019, which bolstered the botulinum toxin market growth of this segment.

Botulinum Toxin Market, by Product Type – 2021 and 2028

Botulinum Toxin Market, by Product Type – 2021 and 2028
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Product launches and mergers and acquisitions are the highly adopted strategies by the players operating in the global botulinum toxin market. A few of the recent key product developments are listed below:

  • In August 2021, Merz Therapeutics was granted the use of XEOMIN for the symptomatic treatment in children and adolescents aged 2 to 17 years of chronic sialorrhea due to neurological/neurodevelopmental disorders on the EU level.
  • In December 2020, Galderma announced that Alluzience had completed its European decentralized procedure resulting in a favorable decision for the first ready-to-use neuromodulator, a wrinkle relaxing injection, in Europe. National approvals now take place across the region in line with local processes in each country.

The COVID-19 pandemic also substantially impacts aesthetic surgeries and botulinum toxin market in the region due to the closure of practices. Board-certified plastic surgeons of The American Society of Plastic Surgeons (ASPS) indicated that COVID-19 caused them to halt performing elective surgical procedures for an average of 8.1 weeks in 2020, or 15% of the year, mirroring a drop in the overall number of procedures conducted the previous year. According to the American Society of Plastic Surgeons (ASPS), the COVID-19 pandemic will result in a 15% drop in the total number of cosmetic procedures in 2020, which is roughly in line with the period practices were closed — with three of the top five procedures focusing on the face. During stay-at-home orders in 2020, minimally invasive cosmetic operations declined slightly more than surgical procedures (16% vs. 14%) for the first time in four years. The following were the top five cosmetic minimally invasive procedures performed in 2020, out of a total of 13.3 million: Type A botulinum toxin (4.4 million procedures). Beyond the COVID-19 pandemic, the market is expected to grow due to newly approved indications, the need for repeat treatments, and a largely favorable reimbursement environment, leading to a significant increase in procedure volume and botulinum toxin market sales.

Botulinum Toxin Market - Segmentation

Botulinum Toxin Market - By Product Type

  • Type A Botulinum Toxin
  • Type B Botulinum Toxin

Botulinum Toxin Market - By Application

  • Medical
    • Chronic Migraine
    • Muscle Spasm
    • Over Reactive Bladder
    • Hyperhidrosis
    • Others
  • Aesthetic
    • Crow's Feet
    • Forehead Lines
    • Frown Lines/ Glabellar
    • Square Jaw/ Masseter
    • Others

Botulinum Toxin Market - By Geography

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • France
    • Germany
    • UK
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific (APAC)
    • China
    • Japan
    • India
    • Australia
    • South Korea
    • Rest of Asia Pacific
  • Middle East & Africa (MEA)
    • Saudi Arabia
    • South Africa
    • UAE
    • Rest of the Middle East & Africa
  • South and Central America (SCAM)
    • Brazil
    • Argentina
    • Rest of South and Central America

Company Profiles In Botulinum Toxin Market

  • AbbVie Inc.
  • Merz Pharma
  • Medytox
  • Sanofi
  • Ipsen Pharma
  • Galderma
  • Revance Therapeutics Inc.
  • Lanzhou Institute of Biological Products Co., Ltd.
  • Candela Medical
  • Daewoong Pharmaceutical Co. Ltd.
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Product Type, Application, and End User

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


What is a Botulinum Toxin?

Botulinum toxins are neurotoxins that attack nerves and cause muscle paralysis. A bacterium known as clostridium botulinum makes these neurotoxins. Healthcare providers use specific bacteria for medical injections. Injections of botulinum toxin block nerve signals to the muscle injected into it. Without a signal, the muscle cannot contract. The result is a reduction in unwanted facial lines or features. Botulinum toxin injections like Botox and Dysport improve the appearance by relaxing the muscles that cause wrinkles. These injections also treat migraines, hyperhidrosis, overactive bladder, and eye problems.

What are the driving factors for the botulinum toxins market across the globe?

Key factors that are driving the growth of this market are the increasing aesthetic procedures and use of botulinum toxin and rising number of noninvasive cosmetic procedures are expected to boost the market growth for the botulinum toxins over the years.

What is the market CAGR value of the botulinum toxins market during the forecast period?

The CAGR value of the botulinum toxins market during the forecasted period of 2021-2028 is 7.8%.

Which product type led the botulinum toxins market?

The type A botulinum toxin segment held the largest share of the market in the global botulinum toxins market in 2021.

Who are the key players in the botulinum toxins market?

The botulinum toxins market majorly consists of players such as AbbVie Inc., Merz Pharma, Medytox, Sanofi, Ipsen Pharma, Galderma, Revance Therapeutics Inc., Lanzhou Institute of Biological Products Co., Ltd., Candela Medical, and Daewoong Pharmaceutical Co. Ltd. amongst others.

Which are the top companies that hold the market share in the botulinum toxins market?

AbbVie Inc. and Merz Pharma are the top two companies that hold huge market shares in the botulinum toxins market.

Which region is expected to witness significant demand for the botulinum toxins market in the coming years?

Global botulinum toxins market is segmented by region into North America, Europe, Asia Pacific, Middle East & Africa and South & Central America. North America held the largest market share for botulinum toxins in 2021. The United States held the largest market in North America for botulinum toxins, and the market is expected to grow due to the rising aesthetic procedures, and growing development of non-invasive aesthetic procedures are projected to accelerate the growth of the botulinum toxins market.

The List of Companies - Botulinum Toxin Market

  1. AbbVie Inc.
  2. Merz Pharma
  3. Medytox
  4. Sanofi
  5. Ipsen Pharma
  6. Galderma
  7. Revance Therapeutics Inc.
  8. Lanzhou Institute of Biological Products Co., Ltd.
  9. Candela Medical
  10. Daewoong Pharmaceutical Co., Ltd.

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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