Homocystinuria Market Size & Share Report forecast by 2028

Homocystinuria Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Method (Diagnostics and Treatment) and End User (Hospitals and Clinics, Diagnostic and Imaging Laboratories, Specialty Clinics, and Academic and Research Institutes), and Geography

Publication Month : Dec 2021

  • Report Code : TIPRE00026172
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 226
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The homocystinuria market is projected to reach US$ 73.96 million by 2028 from US$ 56.58 million in 2021; it is estimated to grow at a CAGR of 3.9% during 2021–2028.

Homocystinuria is a genetic condition in which the body is unable to correctly digest certain protein building blocks (amino acids). Homocystinuria comes in a variety of types, each with its own set of signs and symptoms as well as a hereditary aetiology. Nearsightedness (myopia), dislocation of the lens at the front of the eye, a greater risk of irregular blood clotting, and brittle bones prone to fracture (osteoporosis) or other skeletal abnormalities define the most prevalent form of homocystinuria. Some of the people who are impacted also have developmental delays and learning difficulties.

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Homocystinuria Market: Strategic Insights

homocystinuria-market
Market Size Value inUS$ 56.58 Million in 2021
Market Size Value byUS$ 73.96 Million by 2028
Growth rateCAGR of 3.9% from 2021 to 2028
Forecast Period2021-2028
Base Year2021
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The growth of the homocystinuria market is attributed to the rising deficiencies of vitamin B6 and Vitamin B12 and the growing prevalence of inherited metabolic disorders. However, the lack of awareness about various rare disorders and inherited metabolic disorders hampers the market growth.

Lucrative Regions in Homocystinuria Market

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Market Insights


Rising Vitamin B6 and Vitamin B12 Deficiencies Drive Homocystinuria Market

The increase in vitamin B6 and Vitamin B12 deficiencies patterns leads to several disorders such as anemia, megaloblastic anemia, microcytic anemia, and some kind of metabolic disorders, which is expected to boost the market growth during the forecast period. As vitamin B6 therapy is believed to be an effective therapy against homocystinuria, the deficiency of this vitamin may worsen the condition. Pyridoxine (vitamin B6) acts as a cofactor of beta-synthase and acts as a chaperone for stabilizing several missense mutations. Some of the patients with homocystinuria respond well to pyridoxine therapy, and it helps to lower the homocysteine levels, thereby providing relief from the condition. Thus, vitamin B6 is considered vital in managing homocystinuria as a limited number of treatments are available for curing the condition. The deficiency of this enzyme leads to anemia and microcytic anemia. The rising prevalence of anemia is expected to spur market growth during the forecast period. For instance, according to the World Health Organization, anemia affects over 1.62 billion populations, i.e., 24.8% of the population. The major causes of anemia are improper diet and deficiencies of vitamins such as B6, B9, and B12. Predominantly, vitamin B6 deficiency is a leading cause of anemia. Thus, an increase in cases of vitamin B6 deficiency and a high prevalence of disorders associated with its deficiency is expected to support market growth during the forecast period.

Method-Based Insights

The global homocystinuria market, based on method, is bifurcated into treatment and diagnostics. The treatment segment held a larger share of the market in 2021. Moreover, the same segment is anticipated to register a higher CAGR in the market during the forecast period due to the incumbent usage of treatment and increasing research and development of new treatments for homocystinuria.  

Homocystinuria Market, by Method – 2021 and 2028

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End-User-Based Insights

The global homocystinuria market, based on end-user, is segmented into diagnostics and imaging laboratories, hospitals and clinics, specialty clinics, and academic and research institutes. In 2021, the diagnostics and imaging laboratories segment held the largest share of the market. Moreover, the segment is expected to register the highest CAGR of 4.2% during 2021–2028 due to the rising diagnosis of inherited metabolic disorders in diagnostics and imaging laboratories.

Product launches and approvals are commonly adopted strategies by companies to expand their global footprints and product portfolios. Moreover, the homocystinuria market players focus on the partnership strategy to enlarge their clientele, which, in turn, permits them to maintain their brand name across the world.

The report segments homocystinuria market as follows

Homocystinuria Market – by Method

  • Treatment
    • Pyridoxine
    • Betaine
    • Others
  • Diagnostics
    • Genetic Testing
    • Amino Acid Screening Test
    • Liver Enzyme Test
    • Others

Homocystinuria Market – by End User

  • Hospitals and Clinics
  • Diagnostic and Imaging Laboratories
  • Specialty Clinics
  • Academic and Research Institutes

Homocystinuria Market – by Geography

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Australia
    • South Korea
    • Rest of Asia Pacific
  • Middle East and Africa
    • UAE
    • Saudi Arabia
    • South Africa
    • Rest of Middle East and Africa
  • South and Central America
    • Brazil
    • Argentina
    • Rest of South and Central America

Company Profiles

  • BASF SE
  • HUAZHONG PHARMACEUTICAL
  • Pfizer Inc.
  • MYLAN N.V
  • Aeglea BioTherapeutics
  • Amino GMBH
  • KAO Corporation
  • DSM Corporation
  • Orphan Technologies
  • Fresenius Kabi AG
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Method, End User, and Geography

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Africa, Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


What is the market CAGR value of Homocystinuria market during forecast period?

The global Homocystinuria market is expected to reach US$ 73,960.22 thousand by 2028 from US$ 56,589.20 thousand in 2021; it is estimated to grow at a CAGR of 3.9% during 2021-2028.

What are future trends of Homocystinuria market?

Emergence of human enzyme therapeutics and enzyme replacement therapy to treat rare disorders is one of the future trends of homocystinuria market. Enzyme replacement therapy and enzyme therapeutics is a type of novel drug therapy in which therapeutic enzymes are used to treat chronic and life-threatening diseases such as cancer, idiosyncratic disorders, and rare disorders. Furthermore, if an enzyme is not functioning properly in the body, then enzyme replacement therapy is used for replacing the enzyme that is deficient in the body. Enzymes have a predominant role in pharmaceutical industries and drug development as they treat various disorders. The advancements in the field of protein technology, recombinant DNA technology, enzyme immobilization, and nanotechnology have provided a solid platform for the use of enzymes in the treatment of various disorders.

What are the driving factors for the Homocystinuria market across the globe?

The growth of the Homocystinuria market is mainly attributed to factors such as the increasing prevalence of inherited metabolic disorders coupled with rise in vitamin B6 and Vitamin B12 deficiencies. However, the lack of awareness about various rare disorders and inherited metabolic disorders is hindering the market growth.

Which is the potential market for the Homocystinuria in terms of region??

The Asia Pacific region is expected to be the fastest-growing region among all other regions. The market in this region is expected to grow significantly in countries such as, China, Japan and India. The market is driven by increase in prevalence of inherited metabolic disorders, rise in government initiatives to manage rare diseases across the region along with increase in diagnostic tests across the region such as new born screening test etc. Therefore, the region holds huge potential for the homocystinuria market players to grow during the forecast period.

What does Homocystinuria mean?

Homocystinuria is an inherited disorder in which the body is unable to process certain building blocks of proteins (amino acids) properly. There are multiple forms of homocystinuria, which are distinguished by their signs and symptoms and genetic cause. The most common form of homocystinuria is characterized by nearsightedness (myopia), dislocation of the lens at the front of the eye, an increased risk of abnormal blood clotting, and brittle bones that are prone to fracture (osteoporosis) or other skeletal abnormalities. Some affected individuals also have developmental delay and learning problems.

The List of Companies - Homocystinuria Market

  1. BASF SE
  2. HUAZHONG PHARMACEUTICAL
  3. Pfizer Inc.
  4. MYLAN N.V
  5. Aeglea BioTherapeutics
  6. Amino GMBH
  7. KAO Corporation
  8. DSM Corporation
  9. Orphan Technologies
  10. Fresenius Kabi AG.

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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