Small Molecule Drug Discovery Market to Grow at a CAGR of 9.5% to reach US$ 50,823.06 Million from 2020 to 2027

Small Molecule Drug Discovery Market Forecast to 2027 - COVID-19 Impact and Global Analysis by Therapeutic Area (Oncology, Central Nervous System, Cardiovascular, Respiratory, Orthopedics, Immunology, Rare Diseases, and Other Therapeutic Areas); Process/Phase (Target Discovery, Target Validation, Lead Generation and Refinement, and Preclinical Development); and Geography

  • Report Code : TIPRE00004774
  • Category : Pharmaceuticals
  • Status : Published
  • No. of Pages : 173
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The small molecule drug discovery market was valued at US$ 24,976.14 million in 2019 and is projected to reach US$ 50,823.06 Mn by 2027; it is expected to grow at a CAGR of 9.5% from 2020 to 2027.

Small molecules drugs are used in targeted drug delivery in which small molecules pass through the cell membrane and acts on the specific cellular organelle or protein. The small molecules drugs are able to enter cells easily because of its low molecular weight. These molecules are better than monoclonal antibodies and other large molecule drugs due to their size, easy convertibility to oral form and, cost-effectiveness. The small molecule drug discovery market is expected to witness huge growth due to increasing approval of small molecule drugs, growing demand for R&D from contract organizations, and rising adoption of small molecules in chronic disease treatments. However, high drug development cost is expected to restrain the growth of the market during the forecast period.

Lucrative Regions for Small Molecule Drug Discovery Market



Lucrative Regions for Small Molecule Drug Discovery Market
  • Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.

Market Insights

Rising Adoption of Small Molecules in Chronic Disease Treatments

As per the Centres for Disease Control (CDC), 6 in 10 adults suffer from a chronic condition, such as heart disease, diabetes, cancer, kidney disease, lung disease, or stroke in the US, costing US$ 3.5 trillion to the economy in the US annually for the treatment of these chronic diseases. Chronic diseases are the most significant cause of deaths worldwide, and the number is growing every year. For instance, as per the CDC, more than 1.6 million people are diagnosed with cancer every year in the US.

Small-molecule medicines are expected to provide effective treatment options for chronic diseases owing to their size and ability to cross cell barriers. They can also be designed to cross the blood-brain barrier to target neurological illnesses. Small molecules are expected to play a critical role in reducing the burden of chronic disease. In the coming years, small molecules are expected to help with the formulation of more efficient and effective treatments for chronic conditions.

Therapeutic Area -Based Insights

Based on therapeutic area, the small molecule drug discovery market is segmented into oncology, central nervous system, cardiovascular, respiratory, orthopedics, immunology, rare diseases, and other therapeutic areas. The oncology segment held a largest share of the market in 2019 owing to the increasing small molecule drug approvals and growing pipeline for the cancer therapeutics. Moreover, increasing investment in oncology is further driving the growth of the segment. For instance, In December 2019, Zentalis Pharmaceuticals, a clinical-stage biopharmaceutical company focused on developing clinically differentiated, novel small molecule therapeutics that target fundamental pathways in cancer, completed US$ 85 million Series C financing. However, the rare diseases segment is expected to register a higher CAGR in the market during the forecast period.

Global Small Molecule Drug Discovery Market, by Therapeutic Area – 2019 & 2027
Global Small Molecule Drug Discovery Market, by Therapeutic Area – 2019 & 2027
  • Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.

Process/Phase -Based Insights

Based on process/phase, the small molecule drug discovery market is segmented into target discovery, target validation, lead generation and refinement, and preclinical development. The lead generation and refinement segment held the largest share of the global small molecule drug discovery market in 2019, owing to increasing investment in drug discovery and rising demand of cost-effective therapeutics. Moreover, the discovery of the target involves identification of disease modifying targets, which acts as one of the essential steps in drug discovery pipeline. However, the target discovery is anticipated to register the highest CAGR during the forecast period.

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Small Molecule Drug Discovery Market: Strategic Insights

small-molecule-drug-discovery-market
Market Size Value inUS$ 24,976.14 Million in 2019
Market Size Value byUS$ 50,823.06 Million by 2027
Growth rateCAGR of 9.5% from 2020-2027
Forecast Period2020-2027
Base Year2020
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Collaborations and expansion strategy are commonly adopted by companies to expand their footprint worldwide and meet the growing demand in order to expand its product portfolio.

The market players operating in the small molecule drug discovery market adopted the strategy of product innovation to cater to changing customer demand across the world, which also permits the players to maintain their brand name globally.

Small Molecule Drug Discovery Market – By Therapeutic Area

  • Oncology
  • Central Nervous System
  • Cardiovascular
  • Respiratory
  • Orthopedics
  • Immunology
  • Rare Diseases
  • Other Therapeutic Areas

Small Molecule Drug Discovery Market – By Process/Phase

  • Target Discovery
  • Target Validation
  • Lead Generation and Refinement
  • Preclinical Development

Small Molecule Drug Discovery Market– By Geography

  • North America

    • US
    • Canada
    • Mexico
  • Europe

    • France
    • Germany
    • Italy
    • UK
    • Spain
    • Rest of Europe
  • Asia Pacific(APAC)

    • China
    • India
    • South Korea
    • Japan
    • Australia
    • Rest of APAC
  • Middle East and Africa (MEA)

    • South Africa
    • Saudi Arabia
    • UAE
    • Rest of MEA
  • South America (SAM)

    • Brazil
    • Argentina
    • Rest of SAM

Company Profiles

  • Johnson and Johnson Services, Inc.
  • Teva Pharmaceutical Industries Ltd
  • Boehringer Ingelheim International GmbH
  • Allergan Plc.
  • Pfizer Inc.
  • Bristol-Myers Squibb Company
  • MERCK KGaA
  • GlaxoSmithKline plc.
  • AstraZeneca
  • Gilead Sciences, Inc.
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Therapeutic Area ; Process/Phase ; and Geography

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


What is small molecule drug discovery market?

Small molecules drugs are used in targeted drug delivery in which small molecules pass through the cell membrane and acts on the specific cellular organelle or protein. The small molecules drugs are able to enter cells easily because of its low molecular weight. These molecules are better than monoclonal antibodies and other large molecule drugs due to their size, easy convertibility to oral form and cost affectivity. The discovery of novel small molecule entities that are capable of specific interactions represents a significant challenge in the early stages of drug discovery. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. In the recent years, the small molecules have witnessed significant attention over biologics, as there is an increasing demand for these drugs.

What are the driving factors for the small molecule drug discovery market across the globe?

The factors that are driving growth of the market are increasing approval of small molecule drugs, growing demand for R&D from contract organizations, and rising adoption of small molecules in chronic disease treatments propel the growth of the market.

Who are the major players in the small molecule drug discovery market?

The small molecule drug discovery market majorly consists of the players such as Pfizer Inc., Bristol-Myers Squibb Company, Merck KGaA, GlaxoSmithKline Plc, AstraZeneca, Johnson & Johnson Services, Inc., TEVA PHARMACEUTICAL INDUSTRIES LTD, Boehringer Ingelheim International GmbH, and Allergan Plc.

The List of Companies - Small Molecule Drug Discovery Market

  1. Johnson and Johnson Services, Inc.
  2. Teva Pharmaceutical Industries Ltd
  3. Boehringer Ingelheim International GmbH
  4. Allergan Plc.
  5. Pfizer Inc.
  6. Bristol-Myers Squibb Company
  7. MERCK KGaA
  8. GlaxoSmithKline plc.
  9. AstraZeneca
  10. Gilead Sciences, Inc.

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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