The North America RNAi therapeutics market is expected to reach US$ 598.60 million in 2027 from US$ 302.77 million in 2019. The market is estimated to grow with a CAGR of 9.0% from 2020-2027.
Growing investments in RNAi therapies and rising prevalence of infectious diseases & chronic conditions in North Americaare the key factors driving the growth of RNAi therapeutics. However,high cost of RNAi therapies is the major factor hindering the market growth in North America.RNAi refers to the interference RNA which is responsible to control and manipulate protein translation in the cell. These RNAi are used to silence particular genes which are responsible for diseases. Currently, the awareness about RNAi is increasing extensively due to its ability to offer target specific mechanism, leading to superior treatment outcomes. The approach is widely utilized for drug development. Increasing number of investments in RNAi therapy development coupled with growing prevalence of infectious diseases and chronic conditions are anticipated to drive the market during the forecast period.
The healthcare systems are engaged in the development and implementation of new RNA technologies to treat a wide range of diseases. A few technologies comprise genome editing technology, RNAi therapeutics, DNA-directed interference technology, and RNA-modifying enzymes. With these advantages of the implementation, the demand for RNA technologies continues to grow. This increasing preference for RNAi therapeutics is a leading factor that the number of start-ups is rising, which will, in turn, have a positive impact on activities related to the development of RNA technologies and drugs. For instance, in August 2020, RNAimmune, Inc., a spin-off start-up of Sirnaomics, Inc. raised about US$ 2.35 million through the rounds of series funding. The start-up is actively engaged in the development of RNA therapies and vaccines. Such developments in RNA technologies will reshape the RNAi therapeutics market during the forecast period.
North America has been witnessing growing number of COVID-19 cases since its outbreak. Thus, owing to the rising incidence of COVID-19 in the North America region, there is increase in demand for new therapeutic drugs. Research studies on RNAi therapy for COVID-19 in the region is likely to favor market growth. For instance, the study ‘Prospects for RNAi Therapy of COVID-19’ was conducted in University of Alberta, Edmonton, AB, Canada and was published in July 2020. Thus, growing efforts by pharmaceutical, biotech companies and academic institutes is to treat COVID-19 is likely to propel the growth of the market during the forecast period.
Mexico RNAi Therapeutics Market, Revenue and Forecast to 2027 (US$ Mn)
NORTH AMERICARNAI THERAPEUTICS MARKET SEGMENTATION
By Molecule Type
- Small Interfering RNAs (siRNA)
- MicroRNA (miRNA)
By Route of Administration
- Pulmonary Delivery
- Intravenous Injections
- Intradermal Injections
- Intraperitoneal Injections
- Others
By Application
- Oncology
- Cardiovascular
- Respiratory Disorders
- Renal Diseases
- Genetic Disorders
- Neurodegenerative Disorders
- Infectious Diseases
- Others
By End User
- Research and Academic Laboratories
- Hospitals
- Diagnostic Laboratories
By Country
- US
- Canada
- Mexico
Company Profiles
- Alnylam Pharmaceuticals, Inc
- Arrowhead Pharmaceuticals, Inc
- Quark
- Rexahn Pharmaceuticals, Inc
- Arbutus Biopharma
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
Molecule Type, Application, Route of Administration, and End User
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
US, Canada
1. Introduction
1.1 Scope of the Study
1.2 The Insight Partners Research Report Guidance
1.3 Market Segmentation
1.3.1 North America RNAi Therapeutics Market – By Molecule Type
1.3.2 North America RNAi Therapeutics Market – By Application
1.3.3 North America RNAi Therapeutics Market – By Route of Administration
1.3.4 North America RNAi Therapeutics Market– By End User
1.3.5 North America RNAi Therapeutics Market – By Country
2. North America RNAi Therapeutics Market – Key Takeaways
3. Research Methodology
3.1 Coverage
3.2 Secondary Research
3.3 Primary Research
4. North America RNAi Therapeutics Market – Market Landscape
4.1 Overview
4.2 PEST Analysis
4.2.1 RNAi therapeutics Market - North America PEST Analysis
4.3 Expert Opinion
5. North America RNAi Therapeutics Market - Key Market Dynamics
5.1 Key Market Drivers
5.1.1 Growing Investments in RNAi Therapies
5.1.2 Rising Prevalence of Chronic Conditions and Infectious Diseases
5.2 Market Restraints
5.2.1 High Cost for RNAi Therapy Development
5.3 Market Opportunities
5.3.1 Significant Number of Pipeline Candidates for Strategic Alliances
5.4 Future Trends
5.4.1 Rising Emphasis on RNA Technologies
5.5 Impact analysis
6. RNAi Therapeutics Market – North America Analysis
6.1 North America RNAi Therapeutics Market Revenue Forecasts and Analysis
7. North America RNAi Therapeutics Market Analysis and Forecasts To 2027 – By Molecule Type
7.1 Overview
7.2 North America RNAi Therapeutics Market, By Molecule Type 2019 & 2027 (%)
7.2.1 North America RNAi therapeutics Market Revenue and Forecasts to 2027, By Molecule Type (US$ Mn)
7.3 Small Interfering RNAs (siRNA)
7.3.1 Overview
7.3.2 North America Small Interfering RNAs (siRNA) Market Revenue and Forecast to 2027 (US$ Mn)
7.4 MicroRNA (miRNA)
7.4.1 Overview
7.4.2 North America MicroRNA (miRNA) Market Revenue and Forecasts to 2027 (US$ Mn)
8. North America RNAi therapeutics Market Analysis and Forecasts To 2027 – By Application
8.1 Overview
8.2 North America RNAi therapeutics Market, By Application 2019 & 2027 (%)
8.2.1 North America RNAi therapeutics Market Revenue and Forecasts to 2027, By Application (US$ Mn)
8.3 Genetic Disorders
8.3.1 Overview
8.3.2 North America Genetic Disorders Market Revenue and Forecast to 2027 (US$ Mn)
8.4 Oncology
8.4.1 Overview
8.4.2 North America Oncology Market Revenue and Forecasts to 2027 (US$ Mn)
8.5 Neurodegenerative Disorders
8.5.1 Overview
8.5.2 North America Neurodegenerative Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
8.6 Cardiovascular Disorders
8.6.1 Overview
8.6.2 North America Cardiovascular Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
8.7 Respiratory Disorders
8.7.1 Overview
8.7.2 North America Respiratory Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
8.8 Infectious Diseases
8.8.1 Overview
8.8.2 North America Infectious Diseases Market Revenue and Forecasts to 2027 (US$ Mn)
8.9 Renal Diseases
8.9.1 Overview
8.9.2 North America Renal Diseases Market Revenue and Forecasts to 2027 (US$ Mn)
8.10 Other Disorders
8.10.1 Overview
8.10.2 North America Other Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
9. North America RNAi therapeutics Market Analysis and Forecasts To 2027 – By Route of Administration
9.1 Overview
9.2 North America RNAi therapeutics Market, By Route of Administration 2019 & 2027 (%)
9.2.1 North America RNAi therapeutics Market Revenue and Forecasts to 2027, By Route of Administration (US$ Mn)
9.3 Intradermal Injections
9.3.1 Overview
9.3.2 North America Intradermal Injections Market Revenue and Forecast to 2027 (US$ Mn)
9.4 Pulmonary Delivery
9.4.1 Overview
9.4.2 North America Pulmonary Delivery Market Revenue and Forecasts to 2027 (US$ Mn)
9.5 Intravenous Injections
9.5.1 Overview
9.5.2 North America Intravenous Injections Market Revenue and Forecasts to 2027 (US$ Mn)
9.6 Intraperitoneal Injections
9.6.1 Overview
9.6.2 North America Intraperitoneal Injections Market Revenue and Forecasts to 2027 (US$ Mn)
9.7 Other Route of Administrations
9.7.1 Overview
9.7.2 North America Other Route of Administrations Market Revenue and Forecasts to 2027 (US$ Mn)
10. North America RNAi Therapeutics Market Analysis – By End-User
10.1 Overview
10.2 North America RNAi Therapeutics Market, By End-User 2019-2027 (%)
10.2.1 North America RNAi Therapeutics Market Revenue and Forecasts to 2027, By End-User (US$ Mn)
10.3 Diagnostic Laboratories
10.3.1 Overview
10.3.2 North America Diagnostic Laboratories Market Revenue and Forecasts to 2027 (US$ Mn)
10.4 Research and Academic Laboratories
10.4.1 Overview
10.4.2 North America Research and Academic Laboratories Market Revenue and Forecasts to 2027 (US$ Mn)
10.5 Hospitals
10.5.1 Overview
10.5.2 North America Hospitals Market Revenue and Forecasts to 2027 (US$ Mn)
11. RNAi therapeutics Market Revenue and Forecasts To 2027 – Geographical Analysis
11.1 North America: RNAi Therapeutics Market
11.1.1 Overview
11.1.2 North America: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.3 North America: RNAi Therapeutics Market, by Molecule Type, 2018–2027 (USD Million)
11.1.4 North America: RNAi Therapeutics Market, by Application, 2018–2027 (USD Million)
11.1.5 North America: RNAi Therapeutics Market, by Route of Administration, 2018–2027 (USD Million)
11.1.6 North America: RNAi Therapeutics Market, by End User, 2018–2027 (USD Million)
11.1.7 North America: RNAi Therapeutics Market, by Country, 2019 & 2027 (%)
11.1.8 US: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.8.1 US: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.8.2 US: RNAi Therapeutics Market, by Molecule Type, 2018–2027 (USD Million)
11.1.8.3 US: RNAi Therapeutics Market, by Application, 2018–2027 (USD Million)
11.1.8.4 US: RNAi Therapeutics Market, by Route of Administration, 2018–2027 (USD Million)
11.1.8.5 US: RNAi Therapeutics Market, by End User, 2018–2027 (USD Million)
11.1.9 Canada: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.9.1 Canada: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.9.2 Canada: RNAi Therapeutics Market, by Molecule Type, 2018–2027 (USD Million)
11.1.9.3 Canada RNAi Therapeutics Market, by Application, 2018–2027 (USD Million)
11.1.9.4 Canada: RNAi Therapeutics Market, by Route of Administration, 2018–2027 (USD Million)
11.1.9.5 Canada: RNAi Therapeutics Market, by End User, 2018–2027 (USD Million)
11.1.10 Mexico: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.10.1 Mexico: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
11.1.10.2 Mexico: RNAi Therapeutics Market, by Molecule Type, 2018–2027 (USD Million)
11.1.10.3 Mexico: RNAi Therapeutics Market, by Application, 2018–2027 (USD Million)
11.1.10.4 Mexico: RNAi Therapeutics Market, by Route of Administration, 2018–2027 (USD Million)
11.1.10.5 Mexico: RNAi Therapeutics Market, by End User, 2018–2027 (USD Million)
12. Impact of COVID-19 Pandemic on North America RNAi therapeutics Market
12.1 North America: Impact Assessment of COVID-19 Pandemic
13. Company Profiles
13.1 Alnylam Pharmaceuticals, Inc.
13.1.1 Key Facts
13.1.2 Business Description
13.1.3 Products and Services
13.1.4 Financial Overview
13.1.5 SWOT Analysis
13.1.6 Key Developments
13.2 Arrowhead Pharmaceuticals, Inc
13.2.1 Key Facts
13.2.2 Business Description
13.2.3 Products and Services
13.2.4 Financial Overview
13.2.5 SWOT Analysis
13.2.6 Key Developments
13.3 Quark
13.3.1 Key Facts
13.3.2 Business Description
13.3.3 Products and Services
13.3.4 Financial Overview
13.3.5 SWOT Analysis
13.3.6 Key Developments
13.4 Rexahn Pharmaceuticals, Inc
13.4.1 Key Facts
13.4.2 Business Description
13.4.3 Products and Services
13.4.4 Financial Overview
13.4.5 SWOT Analysis
13.4.6 Key Developments
13.5 Arbutus Biopharma
13.5.1 Key Facts
13.5.2 Business Description
13.5.3 Products and Services
13.5.4 Financial Overview
13.5.5 SWOT Analysis
13.5.6 Key Developments
14. Appendix
14.1 About The Insight Partners
14.2 Glossary of Terms
LIST OF TABLES
Table 1. North America RNAi therapeutics Market Revenue and Forecasts To 2027, By Molecule Type (US$ Mn)
Table 2. North America RNAi therapeutics Market Revenue and Forecasts To 2027, By Application (US$ Mn)
Table 3. North America RNAi therapeutics Market Revenue and Forecasts To 2027, By Route of Administration (US$ Mn)
Table 4. North America RNAi Therapeutics Market Revenue and Forecasts To 2027, By End-User (US$ Mn)
Table 5. North America RNAi Therapeutics Market, by Molecule Type– Revenue and Forecast to 2027 (USD Million)
Table 6. North America RNAi Therapeutics Market, by Application – Revenue and Forecast to 2027 (USD Million)
Table 7. North America RNAi Therapeutics Market, by Route of Administration – Revenue and Forecast to 2027 (USD Million)
Table 8. North America RNAi Therapeutics Market, by End User – Revenue and Forecast to 2027 (USD Million)
Table 9. US RNAi Therapeutics Market, by Molecule Type – Revenue and Forecast to 2027 (USD Million)
Table 10. US RNAi Therapeutics Market, by Application – Revenue and Forecast to 2027 (USD Million)
Table 11. US RNAi Therapeutics Market, by Route of Administration – Revenue and Forecast to 2027 (USD Million)
Table 12. US RNAi Therapeutics Market, by End User – Revenue and Forecast to 2027 (USD Million)
Table 13. Canada RNAi Therapeutics Market, by Molecule Type – Revenue and Forecast to 2027 (USD Million)
Table 14. Canada RNAi Therapeutics Market, by Application – Revenue and Forecast to 2027 (USD Million)
Table 15. Canada RNAi Therapeutics Market, by Route of Administration – Revenue and Forecast to 2027 (USD Million)
Table 16. Canada RNAi Therapeutics Market, by End User – Revenue and Forecast to 2027 (USD Million)
Table 17. Mexico RNAi Therapeutics Market, by Molecule Type – Revenue and Forecast to 2027 (USD Million)
Table 18. Mexico RNAi Therapeutics Market, by Application – Revenue and Forecast to 2027 (USD Million)
Table 19. Mexico RNAi Therapeutics Market, by Route of Administration – Revenue and Forecast to 2027 (USD Million)
Table 20. Mexico RNAi Therapeutics Market, by End User – Revenue and Forecast to 2027 (USD Million)
Table 21. Glossary of Terms, RNAi Therapeutics Market
LIST OF FIGURES
Figure 1. RNAi Therapeutics Market Segmentation
Figure 2. North America RNAi Therapeutics Market Overview
Figure 3. Small Interfering RNAs (siRNA) Molecule Type Segment Held Largest Share of RNAi Therapeutics Market
Figure 4. US is Expected to Show Remarkable Growth During the Forecast Period
Figure 5. North America RNAi Therapeutics Market - Leading Country Markets (US$ Mn)
Figure 6. RNAi Therapeutics Market - North America PEST Analysis
Figure 7. RNAi Therapeutics Market Impact Analysis of Driver and Restraints
Figure 8. North America RNAi Therapeutics Market – Revenue Forecasts and Analysis – 2019- 2027
Figure 9. North America RNAi Therapeutics Market, By Molecule Type 2019 & 2027 (%)
Figure 10. North America Small Interfering RNAs (siRNA) Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 11. North America MicroRNA (miRNA) Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 12. North America RNAi therapeutics Market, By Application 2019 & 2027 (%)
Figure 13. North America Genetic Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 14. North America Oncology Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 15. North America Neurodegenerative Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 16. North America Cardiovascular Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 17. North America Respiratory Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 18. North America Infectious Diseases Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 19. North America Renal Diseases Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 20. North America Other Disorders Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 21. North America RNAi therapeutics Market, By Route of Administration 2019 & 2027 (%)
Figure 22. North America Intradermal Injections Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 23. North America Pulmonary Delivery Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 24. North America Intravenous Injections Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 25. North America Intraperitoneal Injections Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 26. North America Other Route of Administrations Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 27. North America RNAi Therapeutics Market, by End-User 2019 & 2027 (%)
Figure 28. North America Diagnostic Laboratories Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 29. North America Research and Academic Laboratories Mark et Revenue and Forecasts to 2027 (US$ Mn)
Figure 30. North America Hospitals Market Revenue and Forecasts to 2027 (US$ Mn)
Figure 31. North America: RNAi Therapeutics Market, by Key Country – Revenue (2019) (USD Million)
Figure 32. North America RNAi Therapeutics Market Revenue and Forecast to 2027 (USD Million)
Figure 33. North America: RNAi Therapeutics Market, by Country, 2019 & 2027 (%)
Figure 34. US: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
Figure 35. Canada: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
Figure 36. Mexico: RNAi Therapeutics Market – Revenue and Forecast to 2027 (USD Million)
Figure 37. Impact of COVID-19 Pandemic in North American Country Markets
The List of Companies - North America RNAi Therapeutics Market
- Alnylam Pharmaceuticals, Inc
- Arrowhead Pharmaceuticals, Inc
- Quark
- Rexahn Pharmaceuticals, Inc
- Arbutus Biopharma
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- 3.1 Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- 3.2 Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- 3.3 Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- 3.4 Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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