生物反应器市场基于(关键地区、市场参与者、规模和份额)- 到 2030 年的预测

  • Report Code : TIPHE100000880
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 176
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【研究报告】生物反应器市场规模预计将从2022年的36.430亿美元增长到2030年的65.7076亿美元;预计2022年至2030年复合年增长率为7.65%。
分析师的观点
生物反应器市场分析解释了市场驱动因素和市场未来趋势。一次性生物反应器的日益普及以及制药和生物技术行业的快速增长等因素是市场发展的关键驱动力。然而,严格的监管框架正在阻碍市场的增长。此外,生物反应器的技术进步预计将在 2022-2030 年期间引入市场新趋势。根据规模,预计全规模生产领域在预测期内的复合年增长率最高为 8.32%。根据应用,细胞培养应用领域在 2022 年占据最大的市场份额。根据技术,灌注生物反应器领域预计在预测期内复合年增长率高达 8.58%。
按最终用户划分,研究和开发组织细分市场在 2022 年占据最大市场份额,预计在预测期内复合年增长率最高,达到 8.34%。
生物反应器是一种用于培养生物体(例如酵母、细菌、或动物细胞)在规定的情况下用于制造药物、疫苗和抗体。在生物反应器中,全细胞或无细胞酶将输入成分代谢为生化产品和/或较少不需要的副产品。
市场洞察
越来越多地采用一次性生物反应器以及制药和生物技术行业的快速增长
许多制造商正在开发一次性生物反应器 (SUB),因为它们坚固耐用,并提供生物制药商业制造所需的高性能。薄膜技术、搅拌机制、生物反应器设计和传感器系统等优势促进了一次性反应器从实验室到生产规模的广泛采用。一次性生物反应器提供下一代细胞和基因疗法以及连续生物加工。细胞培养工艺的进步提高了滴度和细胞密度,这促进了 SUB 的采用。
SUB 降低了污染风险并缩短了生产周转时间。在过去几年中,一次性生物反应器在现代生物制药工艺中的使用有所增加,因为它们具有增强灵活性、减少投资和限制运营成本的独特能力。此外,许多公司还开发了一次性生物反应器来生产各种治疗药物。缩短验证时间是一次性生物反应器的基本优势之一。因此,上游生物加工越来越多地采用一次性生物反应器推动了市场增长。
近年来,制药行业一直在以前所未有的速度增长。大型制药公司和合同研究组织 (CRO) 正在开发新的药物和治疗形式来治疗多种适应症。生物制药市场正在不断扩大。对生物制剂和生物仿制药的强劲需求推动了该行业的增长。生物制药行业是对经济最重要的贡献者之一。除此之外,基因和细胞疗法的批准不断增加有利于市场增长。批准的基因疗法包括用于治疗脂蛋白脂肪酶缺乏症的 Glybera 和治疗 ADA 严重联合免疫缺陷症的 Strimvelis。因此,上述因素增加了对各种治疗药物大规模生产的需求,从而促进了全球生物反应器市场的增长。
战略见解
未来趋势
生物反应器的技术进步
生物反应器领域的进步为市场参与者提供了许多机会。过去几年,领先企业纷纷推出创新产品。生物反应器的改进使生物制药的生产变得更快、更容易,同时降低了生产成本。 2021年2月,药明生物位于中国的MFG5原料药(DS)生产工厂启动了36,000L产能的GMP运营,并部署了9个4,000L一次性生物反应器。作为公司全球产能规划的一个重要里程碑,MFG5的GMP实施使药明生物现有产能达到90,000L,显着增强了其支持全球合作伙伴的能力。
新型生物反应器是为药明生物的增长而开发的。微载体上的贴壁细胞可在疫苗开发中实现快速、可扩展的细胞培养过程。此类新型生物反应器的推出增强了该公司在生物反应器市场的产品组合。 2022 年 6 月,ABEC 宣布 mAbxience 计划在其位于西班牙莱昂的最先进的 cGMP 设施中添加一个 4,000L 一次性定制单次运行 (CSR) 生物反应器。 2021 年 5 月,贝克曼库尔特生命科学公司在德国推出了新一代 Biolector XT 微生物反应器。 BioLector XT 微生物反应器能够监测培养参数、高通量菌株筛选和优化补料策略。
生物反应器的进步为大多数行业(例如制药、石化、食品和农业)增加了各种解决方案。因此,技术进步预计将在未来几年推动生物反应器市场的创新。
报告细分和范围
“全球生物反应器市场”根据规模、应用、技术、最终用户和地理。
基于规模的见解
生物反应器市场按规模划分为实验室规模生产、中试规模生产和大规模生产。中试规模生产领域在 2022 年占据更大的市场份额。然而,预计全面生产领域在预测期内将实现更高的复合年增长率。出于实验室目的,台式生物反应器被广泛使用。它们可用于最大 15L 的培养物。台式生物反应器用于微生物、哺乳动物、昆虫和植物细胞的生长研究、培养基优化、多变量过程优化研究以及小规模蛋白质和 mAB 表达。这些生物反应器已广泛用于工艺开发和优化、放大和缩小研究、种子扩增、细胞库生产和蛋白质供应等过程。 Infors AG、Sartorius AG 和 Eppendorf 等公司均提供台式生物反应器。赛多利斯提供各种台式生物反应器。这些台式生物反应器用于细胞培养以及微生物发酵。这些是可高压灭菌的培养容器,容量为 1–10L,以及 250ml 和 2L 的一次性容器。台式反应器提供的好处是节省开发实验室中宝贵的工作台空间、易于清洁、为整洁的工作场所提供额外的存储空间,并根据最新标准提高测量安全性和过程控制。
生物反应器市场,按规模 – 2022 年和 2030 年
基于应用的见解
根据应用,生物反应器市场分为微生物应用、细胞培养应用等。细胞培养应用领域在 2022 年占据最大的市场份额。然而,微生物应用领域预计在预测期内复合年增长率最高。
微生物培养包括用于各种目的的细菌和病毒细胞培养物的培养,例如生物医药、化学品等产品的基础研发和制造。大肠杆菌的细菌培养物是生产重组蛋白的优选微生物。它广泛用于克隆、基因改造和研究目的的小规模生产。此外,生物反应器对于细胞培养中大规模病毒疫苗的生产至关重要。根据 Frontiers 2020 年 2 月发表的一篇文章,生物反应器已发展成为利用细胞生产各种病毒载体、活病毒和基于病毒的疫苗的平台。补料分批培养、灌注培养和基因工程的发展促进了这一进步。此外,智能传感器和执行器在生物反应器控制系统中的应用为在不久的将来改善生物过程控制带来了巨大的希望。随着疫苗生产工艺的进步,更可扩展的生物反应器和具有高病毒亲和力的细胞系已被用来生产多种疫苗。
基于技术的见解
基于技术,生物反应器市场分为补料分批生物反应器和灌注生物反应器。补料分批生物反应器细分市场将在 2022 年占据更大的市场份额。
在补料分批系统中,新鲜培养基或培养基成分会连续、间歇或单独添加,而批次体积会随着时间的推移而增加。在补料分批发酵过程中,营养环境可以保持在一致的水平。这可以防止通常由高浓度底物引起的副产物的产生。通过使用这种方法,可以延长操作时间并实现高细胞浓度,从而提高生产率(以单位体积和时间的产品质量来衡量)。该方法在生长相关产品的生产中特别有用。由于上述优点,用于生产细胞培养物的分批补料生物反应器的需求正在增长。
基于最终用户的见解
生物反应器市场,从最终用户来看,分为生物制药制造商、研究和开发组织和合同制造组织 (CMO)。研发组织细分市场在 2022 年占据最大市场份额,预计在预测期内复合年增长率最高。
在生物技术、医疗保健和制药等行业,研发发挥着重要作用关键的角色。研究和开发组织参与生物反应器市场创新和引进新产品、技术和服务的流程和活动。研究和开发对于加速产品推出也很重要。研究和开发组织的增长主要归因于研究和创新过程越来越多地采用生物反应器。此外,研究机构正在大力投资以促进生物工艺,从而促进市场增长。
区域分析
全球生物反应器市场按地区划分为北美、欧洲、亚太地区、中东和非洲,以及南美洲和中美洲。北美区域市场预计 2022-2030 年复合年增长率为 6.81%。
北美生物反应器市场分为美国、加拿大和墨西哥。北美市场的增长归因于生物制药和生物技术公司对生物反应器系统的需求不断增长、市场参与者的存在以及各个学术和研究机构不断增长的研发。此外,制药和生物技术公司不断增加的研究预计将刺激北美生物反应器市场的增长。美国是生物反应器的最大市场——美国的一些市场参与者为制药和生物技术公司的各种应用生产生物反应器。新生物反应器的推出、地域扩张以及市场参与者的合作伙伴关系推动了市场的增长。例如,2023 年 4 月,BioMADE 宣布了五个新项目,重点是通过推进生物反应器技术来解决美国生物工业制造的研究和采用差距。
该报告介绍了全球生物反应器市场的领先参与者。其中包括 Sartorius AG、PBS Biotech、Merck KGaA、Cellexus International Ltd、通用电气公司、Thermo Fisher Scientific Inc、bbi-biotech GmbH、Pall Corp、Applikon Biotechnology BV 和 Solaris Biotechnology SRL。这些公司专注于新产品发布和地域扩张,以满足全球不断增长的消费者需求,并增加其专业产品组合的产品范围。他们在全球范围内拥有广泛的业务,这使他们能够为大量客户提供服务,从而提高市场份额。
生物反应器市场主要参与者采取的各种举措如下:
2023 年 8 月,Sartorius与 Repligen 合作推出了先进的生物反应器系统,该系统将 Repligen XCell ATF 上游强化技术融入 Sartorius 的 Biostat STR 生物反应器中。根据两家公司的公告,此次合作旨在简化生物制药制造商强化种子培养和氮气灌注的实施。2023 年 4 月,Cytiva 推出了 X 平台生物反应器,以简化一次性上游生物加工操作。这些生物反应器最初提供 50 升和 200 升尺寸,并配备 Figurate 自动化解决方案软件。它们具有一系列优势,可以通过改善人体工程学、提高生产能力和简化供应链运营来帮助提高流程效率。
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

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to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

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Frequently Asked Questions


What is the market CAGR value of bioreactors market during forecast period?

The CAGR value of the bioreactors market during the forecasted period of 2022-2030 is 7.65%.

What are bioreactors?

A bioreactor is an instrument used to cultivate organisms (such as yeast, bacteria, or animal cells) under regulated circumstances used in the manufacturing of medicines, vaccines, and antibodies. In bioreactors, whole cells or cell-free enzymes metabolize the input components into biochemical products and/or less undesired byproducts.

Which technology segment leads the bioreactors market?

The fed-batch bioreactors segment held the largest share of the market in the global breath analyzers market and held the largest market share of 62.1% in 2022.

What are the driving factors for the bioreactors market across the globe?

Key factors that are driving the growth of this market are the increasing adoption of single-use bioreactors and rapid growth of the pharmaceutical and biotechnology industry.

Which application held the largest share in the bioreactors market?

The cell culture application segment dominated the global bioreactors market and held the largest market share of 48.6% in 2022.

Who are the key players in the bioreactors market?

The bioreactors market majorly consists of the players such Sartorius AG, PBS Biotech, Merck KGaA, Cellexus International Ltd, General Electric Co, Thermo Fisher Scientific Inc, bbi-biotech GmbH, Pall Corp, Applikon Biotechnology BV, and Solaris Biotechnology SRL.

Which are the top companies that hold the market share in bioreactors market?

Merck KGaA and Thermo Fisher Scientific, Inc. are the top two companies that hold huge market shares in the bioreactors market.

Which region is expected to witness significant demand for bioreactors market in the coming years?

Global bioreactors market is segmented by region into North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. The North America regional market is expected to grow with a CAGR of 6.81% during 2022–2030. The market growth in North America is attributed to the increasing demand for bioreactor systems from biopharmaceutical and biotechnology companies, the presence of market players, and growing R&D by various academic and research institutes. Europe held the second largest market share of the bioreactors market in 2022. With several European market players focusing on research and development activities in the field of bioreactors, the regional market for bioreactcors market is likely to propel in Europe region during the forecast period.

The List of Companies - Bioreactors Market

  1. Sartorius AG
  2.  PBS Biotech
  3.  Merck KGaA
  4.  Cellexus International Ltd
  5.  General Electric Co
  6.  Thermo Fisher Scientific Inc
  7.  bbi-biotech GmbH
  8.  Pall Corp
  9.  Applikon Biotechnology BV
  10.  Solaris Biotechnology SRL

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