基于(关键地区、市场参与者、规模和份额)的基因组编辑市场 - 到 2031 年的预测

  • Report Code : TIPHE100000853
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 176
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[研究报告]2021年基因组编辑市场规模为51.994亿美元,预计到2028年将达到169.8669亿美元;预计 2021 年至 2028 年复合年增长率为 18.4%。

 

分析师的观点

基因组编辑技术用于对细胞或生物体的 DNA 进行改变生物。该技术涉及切割 DNA 序列以添加或删除基因组中的 DNA。基因组的改变是为了满足细胞所需的特征。基因组编辑是为了研究目的、疾病治疗和生物技术目的而进行的。全球基因组编辑市场的增长归因于癌症和癌症患病率的上升。其他遗传性疾病和基因编辑工具的不断技术进步是推动市场增长的因素。此外,医疗保健 IT 领域的技术进步允许使用人工智能 (AI) 来制造 CRISPR 系统,预计将在未来几年促进基因组编辑并促进基因组编辑市场的增长。例如,2019年3月,Oxford Biomedica plc与微软研究院合作研发云和机器学习,以提高LentiVector等下一代基因治疗载体的产量和质量。在此次合作下,牛津生物医学公司利用微软的Azure智能云平台进行计算机模型和创新算法的开发,以推进下一代细胞和基因传递技术。

市场概述

基因组编辑或基因编辑是基因编辑的一种,涉及插入、删除或替换生物体基因组中的 DNA,以使用工程核酸酶或分子剪刀治疗特定疾病。核酸酶在基因组中产生位点特异性双链断裂,并通过非同源末端连接或同源重组进行修复,从而产生靶向突变。推动基因组编辑市场增长的一些因素包括癌症和其他遗传性疾病的增加、对个性化医疗的日益偏好、私人和公共资金的增加以及测序和基因组编辑技术的快速进步。促进基因组编辑市场增长的另一个因素是合作。例如,礼来公司 (Eli Lilly) 于 2020 年 11 月与 Precision BioSciences 合作,使用 ARCUS 平台开发遗传性疾病的体内治疗方法,这项合作可为这家位于北卡罗来纳州达勒姆的公司带来 27 亿美元的收入,该公司开发基因组编辑和 CAR T因此,合作将在预测期内促进基因组编辑市场的增长。

战略洞察

市场驱动因素

< h3>癌症和其他遗传性疾病患病率上升

根据世界卫生组织 (WHO) 的数据,癌症是全球最大的死亡原因,2020 年约有 1000 万人死亡。总体而言,全球负担癌症发病率和死亡人数迅速增加,反映出人口老龄化和增长,以及主要癌症危险因素患病率和分布的变化,其中许多与社会经济发展有关。 《今日癌症》根据 GLOBOCAN 对 185 个国家或地区按性别和年龄组划分的 36 种癌症的 2020 年发病率、死亡率和患病率的估计,对 2020 年全球癌症负担进行了全面评估。根据最近的估计,发生率癌症以惊人的速度增加,使得肝细胞癌(HCC 成为男性第五大常见癌症,女性第七大最常见癌症。HCC 可能占所有人类癌症的 5.6% 左右,从而增加 2020 年的负担. HCC 是全球癌症相关死亡的第二大原因。近 85% 的 HCC 发生在发展中国家。其他类型的肝癌包括胆管细胞癌 (CCC),一种肝胆管的恶性疾病,肝母细胞瘤。肝母细胞瘤是儿童肝脏最常见的恶性肿瘤。根据美国疾病控制与预防中心 (CDC) 的数据,美国每年约有 21,000 名男性和约 8,000 名女性罹患肝癌,约 16,000 名男性和 8,000 名女性罹患肝癌女性死于这种疾病。因此,全球肝脏疾病(包括慢性和急性疾病以及微生物感染)患病率的上升增加了对肝脏模型的需求。

大约每 150 名活产儿中就有 1 名存在染色体异常。然而,即使如此高的发生率也仅代表染色体突变的一小部分,因为绝大多数都是致命的,并导致产前死亡或死产。事实上,据估计,所有早孕期流产中的 50% 和所有中孕期流产中的 20% 都涉及染色体异常的胎儿。尽管唐氏综合症是最广为人知和公认的常染色体三体性,但只有大约每 800 名活产儿中就有 1 人被诊断出患有唐氏综合症。许多癌症生物学研究现在都使用 CRISPR 作为标准方法。 CRISPR/Cas9系统已被证明可有效治疗转移性肿瘤,这是朝着发现癌症治疗方法迈出的一大步。 CRISPR-LNPs系统包含编码Cas9 CRISPR酶的信使RNA,该酶充当分子剪刀来切割细胞的DNA。基于 CRISPR 的研究为治疗遗传性或发育性神经系统疾病(HND)(例如脆性 X 综合征和唐氏综合症)打开了新的大门。

因此,基因组因素的增加编辑预计将在预测期内推动基因组编辑市场的增长。

 

细分分析

技术见解

基于从技术上看,基因组编辑市场分为CRISPR、TALEN、反义等。 CRISPR 细分市场可能会在 2021 年占据最大的市场份额,并且由于其现有的使用量、高消费量和产品创新,预计在预测期内将实现市场上最高的复合年增长率。成簇的规则间隔的短回文重复序列 (CRISPR) 与 Cas 基因相关,而 Cas 基因对于特定细菌和古细菌的适应性免疫至关重要。 CRISPR使生物体能够应对入侵遗传物质的变化和消除。基因组编辑方案采用了多种类型的 CRISPR 机制。第一个是野生型 Cas9,第二个是突变型 Cas9,第三个是核酸酶缺陷型 Cas9。

CRISPR-Cas9 更快、更便宜、更准确与其他DNA编辑技术相比,应用范围更广。它是最简单、最通用、最精确的基因操作方法。提供 CRISPR 的公司包括 Sangamo Therapeutics、Editas Medicine、ThermoFisher Scientific、Horizon Discovery Groups 等。由于 CRISPR 简单、快速和准确的特性,该领域的市场预计在未来的预测几年中将以最快的速度增长。

应用见解

全球基因组编辑市场根据应用分为细胞系工程、基因工程、诊断应用、药物发现等。 2021年,细胞系工程领域可能会占据最大的市场份额。此外,由于全球各种医疗状况的检测和诊断的增加,预计该领域的需求将从 2021 年到 2028 年以最快的复合年增长率增长。细胞系工程主要在实验室中完成,其目的是了解疾病和治疗背后的基础生物学。细胞系工程提供了诸如优化重组蛋白表达的细胞系和表征转基因生物体的蛋白质谱等益处。细胞系工程可以生产各种工业和商业产品,当产品按照所需要求生产时,这些产品可以获得更多收入。

Horizon Discovery 等市场参与者、ThermoFisher Scientific、Lonza、Merck KGaA、Biognosys 等提供细胞系工程产品和服务。其具有多种优点,例如成本效益高、易于使用、提供无限量的材料供应以及绕过与使用动物和人体组织相关的伦理问题。此外,细胞系工程还使研究人员在开发疫苗、测试药物代谢和细胞毒性、抗体生产、基因功能研究、人工组织生成(以及生物化合物的合成)方面受益。因此,细胞系工程的优势可能是在未来的预测几年中将显着增长,预计将推动基因组编辑市场的增长。

最终用户洞察

全球基因组编辑市场根据最终用户,可分为制药和生物技术公司、学术和研究机构以及临床研究组织 (CRO's)。2021 年,制药和生物技术公司细分市场可能会占据最大的市场份额。此外,由于全球各种医疗状况的检测和诊断的增加,预计该细分市场的需求将在 2021 年至 2028 年期间以最快的复合年增长率增长。

< h3>基因组编辑市场,按最终用户划分 – 2021年和2028年

区域分析

全球基因组编辑市场按地区分为北美、欧洲、亚洲太平洋、中东和非洲、南美和非洲中美洲。北美地区是全球基因组编辑市场的最大股东。基因组编辑市场的增长在美国和加拿大等国家普遍存在,其推动因素包括基因疗法的不断发展、公司和政府机构之间的合作不断加强、政府机构增加资金以推广技术开发 CRISPR 产品并增加对基因组编辑的需求。而墨西哥由于越来越多地采用基因组编辑来治疗遗传性疾病和癌症,预计将为基因组编辑市场提供增长机会。此外,越来越多的基因组编辑临床试验预计将推动基因组编辑市场的发展。

在北美,美国是最大的基因组编辑市场。畜牧业集团为消费者提供不同的产品和服务,包括肉、奶、蛋等。牲畜体内的遗传变异有助于生产优质原材料,通过自然选择进行进化,以应对不断变化的条件和人类管理的遗传改良计划。

此外遗传性疾病的患病率不断上升以及采用先进的基因疗法治疗慢性病预计将在预测期内推动该国的市场。例如,根据 NIH 国家医学图书馆 2021 年 7 月发布的数据,囊性纤维化是美国白人中观察到的常见遗传病之一。该病的发病率为 2,500 至 3,500 名白人新生儿中就有 1 人患病。然而,囊性纤维化的发病率在该国其他族群中相对较低。这些群体的发病率约为 17,000 名非裔美国人中的 1 名和 1 名亚裔美国人中的 31,000 名。此外,越来越多地采用基因疗法来治疗癌症、市场参与者推出相关产品、监管机构的支持等因素预计将支持美国基因组编辑相关市场。例如,2021年5月,美国食品和药物管理局(FDA)批准Lumakras(Sotorasib)用于靶向治疗肿瘤表达KRAS基因G12C突变的非小细胞肺癌患者。

赛默飞世尔科技公司;默克公司;龙沙;地平线探索集团有限公司;综合 DNA 技术;金斯瑞;新英格兰生物实验室;欧洲金融科学公司; CRISPR Therapeutics 和 Editas Medicine 是全球基因组编辑市场增长的领先企业之一。对其他几个重要的市场参与者进行了分析,以全面了解市场及其生态系统。该报告提供了详细的市场洞察,帮助主要参与者制定基因组编辑市场增长战略。下面提到了一些进展:

  • 2021 年 11 月,领先的综合基因组解决方案提供商 Integrated DNA Technologies (IDT)推出了 rhAmpSeq CRISPR 分析系统,该系统提供了端到端解决方案,用于表征和量化 CRISPR 研究项目中的全套在靶和脱靶基因组编辑事件。
  • 2021 年 12 月领先的基因组编辑公司 Editas Medicine, Inc. 宣布美国食品和药物管理局 (FDA) 已批准 EDIT-301 用于治疗输血依赖性β地中海贫血 (TDT) 的 IND,使该公司能够启动EDIT-301 在 TDT 患者中的 1/2 期临床研究。
  • 2020 年 8 月,细胞系工程基因编辑和基因调节应用领域的全球领导者 Horizon Discovery Group plc 今天宣布将单细胞 RNA seq-linked 汇集 CRISPR 筛选添加到其 CRISPR 筛选服务组合中。该平台提供高质量的筛选数据和生物学见解,以解决目标识别和验证方面的关键差距。
  • 2021 年 12 月,Eurofins Scientific 同意收购日本检测服务提供商 Genetic Lab (G Lab)来自转基因公司,金额未公开。 G Lab 致力于为诊断、生物标志物开发和药物发现提供基于分子生物学的测试。
  • 2021 年 5 月,生命科学试剂领先供应商 New England Biolabs, Inc. 宣布与达成收购 Fluorogenics Limited (FGL) 的协议,该公司是一家总部位于英国的冻干研发服务公司。根据协议条款,FGL将成为NEB的全资子公司。
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North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

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Frequently Asked Questions


Which segment is dominating the genome editing market?

The global genome editing market based on technology, is segmented into CRISPR, TALEN, Antisense, and others. The CRISPR segment held the largest share of the market in 2021 and register the highest CAGR during the forecast period.

What are the driving factors for the genome editing market across the country?

The factors that are driving and restraining factors that will affect the genome editing market in the coming years. Factors such as the rising prevalence of cancer, the growing rate of genetic disorders. However, the high cost of genomics hampers the genome editing market.

Who are the major players in market the genome editing market?

The genome editing market majorly consists of the players such as Thermo Fisher Scientific Inc.; Merck KGaA; Lonza; Horizon Discovery Group plc.; Integrated DNA Technologies; GenScript; New England Biolabs; Eurofins Scientific; CRISPR Therapeutics; Editas Medicine amongst others.

What is the` genome editing market?

Genome editing technologies enable scientists to change DNA, leading to changes in physical traits, like eye color and disease risk. Scientists use different technologies to do this. These technologies act like scissors, cutting the DNA at a specific spot. Then scientists can remove, add, or replace the DNA where it was cut. CRISPR is simpler, faster, cheaper, and more accurate than older genome editing methods. Many scientists who perform genome editing now use CRISPR.

The List of Companies - Genome Editing Market

  1. THERMO FISHER SCIENTIFIC INC.
  2. MERCK KGaA
  3. Lonza
  4. Horizon Discovery Group plc.
  5. Integrated DNA Technologies
  6. GenScript
  7. New England Biolabs
  8. Eurofins Scientific
  9. CRISPR Therapeutics
  10. Editas Medicine

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.

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Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

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The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

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Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

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