Enzymatic DNA Synthesis Market Size, Share Statistics Report 2028

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Enzymatic DNA Synthesis Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Product Type (Custom DNA Synthesis and DNA Library Synthesis), Application (Synthetic Biology, Genetic Engineering, Therapeutic Antibodies, Vaccine Design, and Others), End User (Academic & Research Institutes, Biotech & Pharmaceutical Companies, Diagnostic Laboratories, and Others), and Technology (SOLA, CRISPR, PCR, and Others)

Publication Month: Mar 2023 | Report Code: TIPRE00027647 | No. of Pages: 211 | Category: Biotechnology | Status: Published

The enzymatic DNA synthesis market is expected to grow from US$ 240.96 million in 2022 to US$ 2,244.88 million by 2028; it is estimated to record a CAGR of 45.1% from 2022 to 2028.

Enzymatic DNA synthesis is a well-established technique of DNA synthesis, which is useful in synthetic biology, genetic engineering, therapeutic antibody production, vaccine designing, and other advanced biological procedures. It has also proven helpful in maintaining DNA libraries and synthesizing custom DNA molecules.

Enzymatic DNA Synthesis Market Insights

Rising Prevalence of Genetic Disorders Drives Enzymatic DNA Synthesis Market Growth

Down syndrome, autism spectrum disorder, cancer, diabetes, cystic fibrosis, and sickle cell anemia are a few of the commonly known genetic disorders. Per the Global Genes, more than 10,000 different genetic and rare diseases have been identified, and ~400 million people suffer from rare diseases. Some genetic disorders cause symptoms at birth, while others develop over time. The global burden of genetic diseases appears to be increasing. According to the National Center for Biotechnology Information (NCBI), a US-based medical organization, as of November 2021, genetic disorders were identified in 9.4% of pediatric patients, with 44.7% being critically ill newborns. In addition, 13.17 million patients in the US suffer from unique genetic disorders. According to the Centers for Disease Control and Prevention (CDC) 2022 report, sickle cell disease affects ~100,000 Americans, and it occurs in 1 in 356 African American births. Cystic fibrosis, another common genetic disease worldwide, affects ~30,000 people in the US, and ~1,000 new cases are treated annually. Enzymatic DNA synthesis is a well-established DNA synthesis technique useful in synthetic biology, genetic engineering, and therapeutic antibody studies. In conjunction with enzymatic assays, DNA synthesis shows greater diagnostic possibilities. This method provides important information about people at risk and helps them make important decisions regarding disease diagnosis and medication. Hence, with the rising prevalence of genetic disorders across the world, people are becoming more aware of the need for the early detection of these genetic flaws, which propels the growth of the enzymatic DNA synthesis market

Strategic Insights

Report Coverage - Enzymatic DNA Synthesis Market
Report CoverageDetails
Market Size Value inUS$ 240.96 million in 2022
Market Size Value byUS$ 2,244.88 million by 2028
Growth rateCAGR of 45.1% from 2022 to 2028
Forecast Period2022-2028
Base Year2022
No. of Pages211
No. of Tables111
No. of Charts & Figures77
Historical data availableYes
Segments coveredProduct Type, Application, End User, and Technology
Free Sample Copy Available

High Costs and Complex Procedures Hamper growth of Enzymatic DNA Synthesis Market

Enzymatic DNA synthesis techniques are not mature enough, and further optimization is required before they are rolled out for widespread use. Most are based on the naturally occurring enzyme terminal deoxynucleotidyl transferase (TdT), which is used in biological systems to add new bases to a DNA sequence. TdT-based method is an improved one over the chemical procedure as it avoids the production of hazardous waste. However, the high costs and low accuracy of this enzyme hinder its use in in vitro DNA synthesis. The TdT enzyme is too permissive, adding wrong bases more often than it should. As a result, TdT-based oligos have more sequence errors and may require the same or even more post-synthesis quality control steps, increasing the time and cost of the synthesis process. While working with this enzyme, scientists need to add more reagents to build their target sequence, which further adds to the cost of the entire synthesis process. The cost per base of synthetic DNA obtained using TdT is much high than conventionally synthesized genetic materials. Thus, high costs and complex procedures limit the growth of the enzymatic DNA synthesis market.

Product Type-Based Insights

Based on product type, the enzymatic DNA synthesis market is segmented into custom DNA synthesis and DNA library synthesis. The DNA library synthesis segment held the largest market share in 2021. Further, the custom DNA synthesis segment is anticipated to register the highest CAGR during the forecast period (2022–2028).

Enzymatic DNA Synthesis Market, by Product – 2021 and 2028

Enzymatic DNA Synthesis Market, by Product – 2021 and 2028

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Application-Based Insights

Based on application, the enzymatic DNA synthesis market is segmented into synthetic biologygenetic engineering, therapeutic antibodies, vaccine design, and other applications. The synthetic biology segment held the largest share of the market in 2021. The enzymatic DNA synthesis market for therapeutic antibodies application is expected to grow at the highest CAGR during the forecast period.

End User-Based Insights

Based on end user, the enzymatic DNA synthesis market is segmented into academic & research institutes, biotechnology & pharmaceutical companies, diagnostic laboratories, and others. The biotechnology & pharmaceutical companies segment held the largest share of the market in 2021. The academic & research institutes segment is anticipated to register the highest CAGR in the market during the forecast period (2022–2028).  

Technology-Based Insights

Based on technology, the enzymatic DNA synthesis market is segmented into SOLA, CRISPR, PCR, and others. The PCR segment has the largest share in 2021 and is expected to continue a similar trend during the forecast period. On the other hand, the CRISPR segment is expected to witness the highest CAGR during the forecast period.

Strategies that are prominently adopted by companies in the enzymatic DNA synthesis market mergers and acquisitions. A few recent developments by key market players are listed below: 

  • In April 2022, GenScript launched the industry's first highest-throughput semiconductor chip for DNA synthesis at the annual Built With Biology global conference. Developed using GenScript's proprietary miniature semiconductor chip technology, this high-density DNA synthesis chip allows the synthesis of 8.4 million unique oligos simultaneously.
  • In April 2022, Evonetix Ltd was granted the patent EP3551331B1 for its proprietary thermal control technology for DNA synthesis, and the design and manufacture of its silicon chips in Europe. In addition to extending Evonetix’s IP portfolio, the patent is perceived as a key step in the company’s strategy to develop a benchtop DNA synthesis platform.
  • In March 2022, Molecular Assemblies, Inc. raised US$ 25.8 million Series B financing with the participation of a new investor Casdin Capital, along with all major Series A investors—Agilent Technologies, iSelect Fund, Codexis, LYFE Capital, and Argonautic Ventures. The company intends to use financing proceeds to initiate a key customer program and advance the company’s proprietary fully enzymatic DNA Synthesis technology toward early commercialization.
  • In November 2021, DNA Script received a US$ 2.2 million grant from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) to support the development of next-generation printers capable of enzymatic printing of synthetic DNA and RNA.  

Company Profiles   

  • Telesis Bio Inc
  • Evonetix
  • Ansa Biotechnologies, Inc.
  • Camena Bio
  • GenScript Biotech Corp.
  • Molecular Assemblie
  • DNA Script
  • Touchlight
  • Synbio Technologies
  • Twist Bioscience

Frequently Asked Questions

The Asia Pacific region is expected to be the fastest-growing region in the enzymatic DNA synthesis market over the forecast period due to increasing government investment to provide healthcare facilities, growing advancements in healthcare infrastructure, greater adoption of advanced technologies, and rising healthcare spending in countries such as China, Japan, and India.
The enzymatic DNA synthesis market is expected to be valued at US$ 2,244.88 million in 2028.
The DNA library synthesis segment held the largest share of the market in 2022, owing to the various advantages offered by DNA library synthesis such as systematic, unbiased investigations such as high-throughput screening for discovery biology, directed evolution for protein engineering, and in vitro molecular optimization to generate mutant proteins with improved or novel properties. However, the custom DNA synthesis segment is estimated to register the highest CAGR in the market during the forecast period.
The enzymatic DNA synthesis market is estimated to be valued at US$ 240.96 million in 2022.
The CAGR value of the enzymatic DNA synthesis market during the forecasted period of 2022-2028 is 45.1%.
The enzymatic DNA synthesis market majorly consists of the players, such as Telesis Bio Inc, Evonetix, Ansa Biotechnologies, Inc., Camena Bio, GenScript Biotech Corp., Molecular Assemblie, DNA Script, Touchlight, Synbio Technologies, and Twist Bioscience.
The factors that are driving the growth of the enzymatic DNA synthesis market are the rising prevalence of genetic disorders and surging number of product launches. Also, the growing demand for enzymatic DNA synthesis procedures is expected to provide opportunity for the enzymatic DNA synthesis market in forecasted period.
Enzymatic DNA synthesis (EDS) offers significant advantages in terms of accessibility and convenience, changing the pace and control of iteration and innovation with less environmental impact. The enzymes involved in DNA replication act coordinated to synthesize both leading and lagging strands of DNA simultaneously at the replication fork. Purported benefits of enzymatic synthesis include the ability to avoid the use of harsh chemical substances (which often result in toxic waste) and an ever-increasing ability to produce longer and longer strands of DNA, which in turn not only leads to a "more green" form of DNA synthesis, but also some incredibly powerful new uses for the longer DNA chains (e.g., vaccines, therapeutics, and data storage).

The List of Companies - Enzymatic DNA Synthesis Market

  1. Telesis Bio Inc       
  2. Evonetix                 
  3. Ansa Biotechnologies, Inc.               
  4. Camena Bio           
  5. GenScript Biotech Corp.    
  6. Molecular Assemblies       
  7. DNA Script              
  8. Touchligh
  9. Synbio Technologies          
  10. Twist Bioscience
  • Save and reduce time carrying out entry-level research by identifying the growth, size, leading players and segments in the enzymatic DNA synthesis market.
  • Highlights key business priorities in order to assist companies to realign their business strategies.
  • The key findings and recommendations highlight crucial progressive industry trends in the global enzymatic DNA synthesis market, thereby allowing players across the value chain to develop effective long-term strategies.
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  • Scrutinize in-depth global market trends and outlook coupled with the factors driving the market, as well as those hindering it.
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