Label Free Detection Market Size, Analysis & Forecast to 2028

Label Free Detection Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Product (Instruments and Consumables), Technology (Surface Plasmon Resonance, Bio-Layer Interferometry, Isothermal Titration Calorimetry, Differential Scanning Calorimetry, and Other LFD Technologies), Application (Binding Kinetics, Binding Thermodynamics, Endogenous Receptor Detection, Hit Confirmation, Lead Generation, and Other Applications), and End User (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Contract Research Organizations, and Other End Users)

Publication Month : Feb 2022

  • Report Code : TIPBT00002548
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 198
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The label free detection market is projected to reach US$ 829.71 million in 2028 from US$ 474.82 million in 2021; it is estimated to grow at a CAGR of 8.3% from 2021 to 2028.

Label-Free Detection (LFD) is a technique used for discovering biomolecules and their interactions. This method has emerged as an attractive research and development tool in the pharmaceutical and biotech industry. Label-free technology uses impedance- or optics-based biosensors to measure the changes upon analyte binding to a ligand immobilized on a biosensor surface. This approach enables the interaction to be monitored in real-time without manipulating the individual assay components artificially. A defining feature of label-free technology is the method used for ligand immobilization.

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Label Free Detection Market: Strategic Insights

label-free-detection-market
Market Size Value inUS$ 474.82 Million in 2021
Market Size Value byUS$ 829.71 Million in 2028
Growth rateCAGR of 8.3% from 2021 to 2028
Forecast Period2021-2028
Base Year2021
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The label free detection market is segmented on the basis of product, technology, application, end user and geography. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East & Africa, and South & Central America. The report offers insights and in-depth analysis of the market, emphasizing parameters such as market trends, technological advancements, and market dynamics, along with the analysis of the competitive landscape of the globally leading market players.   

Lucrative Regions for Label Free Detection Market

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Market Insights

Growing Number of Drug Discovery Programs through Academic–Industrial Partnerships to Drive Label Free Detection Market Growth during Forecast Period

Direct partnerships between pharma/biotech companies and academic centers are becoming prevalent. For academic researchers and researchers in pharma, the benefits of these partnerships are evident. Financial support from pharma provides steady funding and increases their opportunity to do impactful work. These collaborations may begin as funding for academic research for promising candidates. The strategy helps pharmaceutical companies fill gaps in their portfolio at lower costs and risks. A few examples of innovative academic–industrial collaborations are—Takeda Pharmaceuticals with Kyoto University in Japan and Stanford University in the US and Sanofi with the University of California, San Francisco (the US). In 2020, Creoptix collaborated with Professor Adriano Aguzzi and the University of Zurich to analyze SARS-CoV-2 antibodies in COVID-19 patients using the Creoptix WAVE system. Therefore, the growing number of drug discovery programs through academic–industrial partnerships propels the growth of the label free detection market.

Product Insights           

Based on product, the global label free detection market is segmented into instruments and consumables. In 2021, the consumable segment held the largest share of the market. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028, owing to the factors such as continuous advancements in label free detection technologies, and rising government investments to advance the developments in biopharmaceutical, and biotechnology sectors.

Technology Insights

Based on technology, the global label free detection market is segmented into surface plasmon resonance, bio-layer interferometry, isothermal titration calorimetry, differential scanning calorimetry, and other LFD technologies. In 2021, the surface plasmon resonance technology segment held the largest share of the market. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028. This growth is owing to the great sensitiveness of this technology and its extensive application in regulating specificity, affinity, and kinetic parameters at the time of the binding of macromolecules.

Application Insights

Based on application, the global label free detection market is segmented into binding kinetics, binding thermodynamics, endogenous receptor detection, hit confirmation, lead generation, and other applications. In 2021, the binding kinetics segment held the largest share of the market. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028. The factors attributing the growth of this segment are rising need of drugs with broad therapeutic index, advancements in structural biology and growing R&D activities to detect corona virus with label free detection method. 

End-User Insights

Based on end-users, the global label free detection market is segmented into pharmaceutical & biotechnology companies, academic & research institutes, contract research organizations and other end users. In 2021, the pharmaceutical and biotechnology companies segment held the largest market share in 2021. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028. This growth is owing to the extensive use of label-free detection technologies by pharmaceutical & biotechnology companies for studying biomolecular interactions in drug discovery.

Label Free Detection Market, by Product – 2021 and 2028

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Product launches, and collaborations are highly adopted strategies by the global label free detection market players. A few of the recent key market developments are listed below:

  • In August 2021, Agilent Technologies Inc. announced the launch of the Agilent Seahorse XF Pro Analyzer, featuring new pharma-oriented workflow solutions incorporating advanced experimental design and analysis tools.
  • In January 2022, Waters Corporation announced that it has acquired the technology assets and intellectual property rights of Megadalton Solutions, Inc., an early-stage developer of Charge Detection Mass Spectrometry (CDMS) technology and services.

The overall impact of COVID-19 on North America’s label free detection market is positive. There have been various factors, including increased incidences of COVID-19 positive patients, growth in research, increasing production of vaccines, outcome study of administered vaccine, and many other factors. For instance, a research published in Journal of American Chemical Society (JACS) showed the label-free digital detection of intact virions. The study revealed that the label-free biosensing method rapidly detected and quantified intact virus in human saliva with single-virion resolution. The cases majorly led to the demand for new diagnostic methods in the countries like the US, Canada, and Mexico. Thus, the label free detection market in North America is positively impacted by COVID-19.

Label Free Detection – Market Segmentation

The global label free detection is segmented on the basis of product, technology, application, end user and geography. In terms of product, the market is segmented into instruments and consumables. Based on technology, the label free detection market is segmented into surface plasmon resonance, bio-layer interferometry, isothermal titration calorimetry, differential scanning calorimetry, and other LFD technologies. Based on application, the market is segmented into binding kinetics, binding thermodynamics, endogenous receptor detection, hit confirmation, lead generation, and other applications. Based on end-users, the label free detection market is segmented into pharmaceutical & biotechnology companies, academic & research institutes, contract research organizations and other end users. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East & Africa, and South and Central America.  

Company Profiles

  • General Electric
  • Perkin Elmer, Inc.
  • AMETEK Inc.
  • F. HOFFMANN-LA ROCHE LTD
  • Spectris
  • METTLER TOLEDO
  • Agilent Technologies, Inc.
  • Waters Corporation
  • Sartorius AG
  • Corning Incorporated
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Product, Technology, Application, and End User

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


What is the label free detection market?

Label-Free Detection (LFD) is a technique used for discovering biomolecules and their interactions. This method has emerged as an attractive research and development tool in the pharmaceutical and biotech industry. Label-free technology uses impedance- or optics-based biosensors to measure the changes upon analyte binding to a ligand immobilized on a biosensor surface. This approach enables the interaction to be monitored in real-time without manipulating the individual assay components artificially. A defining feature of label-free technology is the method used for ligand immobilization.

What are the driving factors for the label free detection market across the country?

The factors that are driving and restraining factors that will affect the label free detection market in the coming years. Factors such as the introduction of high-tech products, and growing number of drug discovery programs through academic-industrial partnerships are driving the market. However, the high cost of LFD instruments is hampering the market growth.

Who are the major players in market the label free detection market?

The label free detection market majorly consists of the players such as General Electric; Perkin Elmer, Inc.; AMETEK Inc.; F. HOFFMANN-LA ROCHE LTD; Spectris; METTLER TOLEDO; Agilent Technologies, Inc.; Waters Corporation; Sartorius AG; Corning Incorporated.

Which segment is dominating the label free detection market?

The global label free detection market based on product, is segmented into instruments and consumables. The consumables held the largest share of the market in 2021 and the same segment register the highest CAGR during the forecast period.

The List of Companies - Label Free Detection Market

  1. General Electric
  2. Perkin Elmer, Inc.
  3. AMETEK Inc.
  4. F. HOFFMANN-LA ROCHE LTD
  5. Spectris
  6. METTLER TOLEDO
  7. Agilent Technologies, Inc.
  8. Waters Corporation
  9. Sartorius AG
  10. Corning Incorporated

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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