Label Free Detection Market Segments and Growth by 2028

The label free detection market is projected to reach US$ 829.71 million in 2028 from US$ 474.82 million in 2021; it is estimated to grow at a CAGR of 8.3% from 2021 to 2028.

Label-Free Detection (LFD) is a technique used for discovering biomolecules and their interactions. This method has emerged as an attractive research and development tool in the pharmaceutical and biotech industry. Label-free technology uses impedance- or optics-based biosensors to measure the changes upon analyte binding to a ligand immobilized on a biosensor surface. This approach enables the interaction to be monitored in real-time without manipulating the individual assay components artificially. A defining feature of label-free technology is the method used for ligand immobilization.

The label free detection market is segmented on the basis of product, technology, application, end user and geography. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East & Africa, and South & Central America. The report offers insights and in-depth analysis of the market, emphasizing parameters such as market trends, technological advancements, and market dynamics, along with the analysis of the competitive landscape of the globally leading market players.   

Market Insights

Growing Number of Drug Discovery Programs through Academic–Industrial Partnerships to Drive Label Free Detection Market Growth during Forecast Period

Direct partnerships between pharma/biotech companies and academic centers are becoming prevalent. For academic researchers and researchers in pharma, the benefits of these partnerships are evident. Financial support from pharma provides steady funding and increases their opportunity to do impactful work. These collaborations may begin as funding for academic research for promising candidates. The strategy helps pharmaceutical companies fill gaps in their portfolio at lower costs and risks. A few examples of innovative academic–industrial collaborations are—Takeda Pharmaceuticals with Kyoto University in Japan and Stanford University in the US and Sanofi with the University of California, San Francisco (the US). In 2020, Creoptix collaborated with Professor Adriano Aguzzi and the University of Zurich to analyze SARS-CoV-2 antibodies in COVID-19 patients using the Creoptix WAVE system. Therefore, the growing number of drug discovery programs through academic–industrial partnerships propels the growth of the label free detection market.

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Label Free Detection Market: Strategic Insights

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Product Insights           

Based on product, the global label free detection market is segmented into instruments and consumables. In 2021, the consumable segment held the largest share of the market. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028, owing to the factors such as continuous advancements in label free detection technologies, and rising government investments to advance the developments in biopharmaceutical, and biotechnology sectors.

Technology Insights

Based on technology, the global label free detection market is segmented into surface plasmon resonance, bio-layer interferometry, isothermal titration calorimetry, differential scanning calorimetry, and other LFD technologies. In 2021, the surface plasmon resonance technology segment held the largest share of the market. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028. This growth is owing to the great sensitiveness of this technology and its extensive application in regulating specificity, affinity, and kinetic parameters at the time of the binding of macromolecules.

Application Insights

Based on application, the global label free detection market is segmented into binding kinetics, binding thermodynamics, endogenous receptor detection, hit confirmation, lead generation, and other applications. In 2021, the binding kinetics segment held the largest share of the market. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028. The factors attributing the growth of this segment are rising need of drugs with broad therapeutic index, advancements in structural biology and growing R&D activities to detect corona virus with label free detection method. 

End-User Insights

Based on end-users, the global label free detection market is segmented into pharmaceutical & biotechnology companies, academic & research institutes, contract research organizations and other end users. In 2021, the pharmaceutical and biotechnology companies segment held the largest market share in 2021. Moreover, the same segment is expected to register the highest CAGR in the market during 2021–2028. This growth is owing to the extensive use of label-free detection technologies by pharmaceutical & biotechnology companies for studying biomolecular interactions in drug discovery.

Product launches, and collaborations are highly adopted strategies by the global label free detection market players. A few of the recent key market developments are listed below:

• In August 2021, Agilent Technologies Inc. announced the launch of the Agilent Seahorse XF Pro Analyzer, featuring new pharma-oriented workflow solutions incorporating advanced experimental design and analysis tools.
• In January 2022, Waters Corporation announced that it has acquired the technology assets and intellectual property rights of Megadalton Solutions, Inc., an early-stage developer of Charge Detection Mass Spectrometry (CDMS) technology and services.

The overall impact of COVID-19 on North America’s label free detection market is positive. There have been various factors, including increased incidences of COVID-19 positive patients, growth in research, increasing production of vaccines, outcome study of administered vaccine, and many other factors. For instance, a research published in Journal of American Chemical Society (JACS) showed the label-free digital detection of intact virions. The study revealed that the label-free biosensing method rapidly detected and quantified intact virus in human saliva with single-virion resolution. The cases majorly led to the demand for new diagnostic methods in the countries like the US, Canada, and Mexico. Thus, the label free detection market in North America is positively impacted by COVID-19.

Label Free Detection Market Regional Insights

The regional trends and factors influencing the Label Free Detection Market throughout the forecast period have been thoroughly explained by the analysts at Insight Partners. This section also discusses Label Free Detection Market segments and geography across North America, Europe, Asia Pacific, Middle East and Africa, and South and Central America.

Label Free Detection Market Report Scope

Label Free Detection Market Players Density: Understanding Its Impact on Business Dynamics

The Label Free Detection Market is growing rapidly, driven by increasing end-user demand due to factors such as evolving consumer preferences, technological advancements, and greater awareness of the product's benefits. As demand rises, businesses are expanding their offerings, innovating to meet consumer needs, and capitalizing on emerging trends, which further fuels market growth.

Market players density refers to the distribution of firms or companies operating within a particular market or industry. It indicates how many competitors (market players) are present in a given market space relative to its size or total market value.

Major Companies operating in the Label Free Detection Market are:

1. General Electric
2. Perkin Elmer, Inc.
3. AMETEK Inc.
4. F. HOFFMANN-LA ROCHE LTD
5. Spectris

Disclaimer: The companies listed above are not ranked in any particular order.

Label Free Detection – Market Segmentation

The global label free detection is segmented on the basis of product, technology, application, end user and geography. In terms of product, the market is segmented into instruments and consumables. Based on technology, the label free detection market is segmented into surface plasmon resonance, bio-layer interferometry, isothermal titration calorimetry, differential scanning calorimetry, and other LFD technologies. Based on application, the market is segmented into binding kinetics, binding thermodynamics, endogenous receptor detection, hit confirmation, lead generation, and other applications. Based on end-users, the label free detection market is segmented into pharmaceutical & biotechnology companies, academic & research institutes, contract research organizations and other end users. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East & Africa, and South and Central America.  

Company Profiles

• General Electric
• Perkin Elmer, Inc.
• AMETEK Inc.
• F. HOFFMANN-LA ROCHE LTD
• Spectris
• METTLER TOLEDO
• Agilent Technologies, Inc.
• Waters Corporation
• Sartorius AG
• Corning Incorporated