Publication Month: Aug 2021 | Report Code: TIPRE00004168 | No. of Pages: 145 | Category: Biotechnology | Status: Published
Protein binding assays assist in analyzing the interaction between two types of proteins. These assays are widely used in the new drug development process.
The protein binding assay market is segmented on the bases of technology, end user, and geography. By geography, the market is broadly segmented into North America, Europe, Asia Pacific, the Middle East and Africa, and South and Central America. The report offers insights and in-depth analysis of the market, emphasizing on parameters such as market trends, technological advancements, and market dynamics, along with the analysis of competitive landscape of the globally leading market players.
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A clinical trial is a crucial and significant step in the determination of the safety and effectiveness of a medical strategy, treatment, and device for commercial usage. These studies also help understand and determine the best medical approaches for a particular therapeutic area. Before the approval of drug molecules or medical devices by the regulatory authorities, a series of clinical studies are conducted. The increasing prevalence of communicable and non-communicable diseases is triggering the demand for the development of new drugs and medical devices, which, in turn, propels the demand for the protein binding assay. As per the data from the US National Library of Medicine, in 2018, there were ~280,801 clinical studies ongoing in 50 states and 204 countries. The following figure shows the rise in the number of studies registered in period of year 2015 to 2020.
Year First Posted
Studies at Start of Year
Studies During Year
Studies at End of Year
Furthermore, pharmaceutical, medical device, and biotechnology companies focus on research and development (R&D) activities to develop new molecules for therapeutic applications with the greatest medical and commercial potential. The companies invest majorly in the R&Ds intending to deliver high quality and innovative products to the market.
Name of Company (R&D Budget as % of Revenue)
Name of Company (R&D Budget as % of Revenue)
1. F. Hoffmann La-Roche Ltd. (19.0%)
2. Johnson & Johnson Services, Inc. (13.8%)
3. Merck KGaA (21.1%)
4. Novartis AG (19.8%)
5. Pfizer, Inc. (16.7%)
6. Sanofi S.A (16.7%)
7. AbbVie, Inc. (19.0%)
8. Bristol Myers Squibb Company Limited (23.6%)
9. AstraZeneca Plc. (24.8%)
10. GlaxoSmithKline Plc (13.8%)
In the early stages of the drug development process, protein binding assays are being developed. Because unbound circulating drugs have the best access to targets and excretion pathways, drug candidate binding to plasma proteins is crucial for drug distribution, efficacy, and safety margin definition. According to Statista, around 7,493 drugs entered the preclinical stage in 2017, and the number is estimated to reach 8,040 in 2018. As a result, the total number of drug candidates being screened each year is increasing. Protein binding studies, which are conducted early in the drug development process, are an important aspect of the preclinical phase. Hence, the rising drug discovery activities coupled with increasing pharmaceutical R&D expenditure drives the growth of the protein binding assay market.
Rising Need of Reducing Drug Discovery and Development Costs Contributes Significantly to Protein Binding Assay Market Growth
The cost of developing new drugs remains high at an inflation-busting rate, and returns and profits on investments are declining, placing pressure on the entire innovative medicine system. Many pharmaceutical and biopharmaceutical research companies are re-evaluating old R&D policies and focusing their efforts on improving efficiency, increasing output, and satisfying unmet patient requirements due to current economic and political pressures to reduce the healthcare cost. The changing focus on drug discovery and development, and the rising use of new technologies for identifying and screening drug candidates are allowing research personnel to tap into various chronic, degenerative, and life-threatening disease segments that were previously untargeted.
Drug discovery and development is a costly process as it requires investments in funding, human resources, and technologies. Before launching a new drug in the market, strict adherence to regulations on testing and manufacturing standards is required. Furthermore, the failure of drug candidate during the development stage results in the wastage of entire investment. Protein binding studies assist in assessing binding and absorption capabilities in preclinical phases, resulting in lower drug attrition in the later stages of development, which helps optimize drug discovery expenses. Thus, rising need of reducing the cost of drug discovery and development process is fueling the protein binding assay market growth.
Based on technology, the global protein binding assay market is segmented into ultracentrifugation ultrafiltration, equilibrium dialysis, surface plasmon, and others. In 2020, the equilibrium dialysis segment held the largest share of the market. However, the ultrafiltration segment is expected to register the highest CAGR in the market during 2021–2028. Equilibrium dialysis is among the most widely accepted methods for evaluating protein binding, and it can be performed with the help of rapid equilibrium dialysis (RED) devices. Researchers prefer this method as it has fewer binding effects to extraneous and unintended factors affecting research results.
Based on end user, the protein binding assay market is segmented into contract research organization, pharmaceutical and biotechnology companies, and research and diagnostic laboratories. The pharmaceutical and biotechnology companies segment is expected to hold the largest market share in 2021. It is also expected to be the largest shareholder in the market by 2028. These companies are the major adopters of CRO services; they approach CROs for outsourcing drug and molecule research and development. Protein binding is a fundamental biochemical process that is used to study the mechanism of drugs along with their pharmacological effects in subjects. These aspects are propelling the protein binding assay market for the market for the pharmaceutical and biotechnology companies segment.
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|Market Size Value in||US$ 340.14 Million in 2021|
|Market Size Value by||US$ 694.63 Million by 2028|
|Growth rate||CAGR of 10.7% from 2021-2028|
|No. of Pages||145|
|No. of Tables||59|
|No. of Charts & Figures||67|
|Historical data available||Yes|
|Segments covered||Technology ; End User , and Geography.|
|Regional scope||North America, Europe, Asia Pacific, Middle East & Africa, South & Central America|
|Country scope||US, Canada, Mexico, UK, Germany, Spain, Italy, France, India, China, Japan, South Korea, Australia, UAE, Saudi Arabia, South Africa, Brazil, Argentina|
|Report coverage||Revenue forecast, company ranking, competitive landscape, growth factors, and trends|
|Free Sample Copy Available|
Product launches, and mergers and acquisitions are highly adopted strategies by the players operating in the global protein binding assay market. A few of the recent key product developments are listed below:
In November 2020, Pharmaron Beijing Co., Limited acquired 100% assets of Absorption Systems, US, for up to US$ 137.5 million in cash. Absorption Systems is a leading scientific, non-clinical contract research organization (CRO) that provides small and large molecules, cell and gene therapies, and ocular and medical device products, among others, to pharmaceutical, biotechnology, and medical device companies; regulatory agencies; and research and testing organizations.
In April 2020, Sartorius acquired selected assets of Danaher Life Sciences successfully. The transaction was completed after obtaining the required regulatory approvals.
The pace of research and development of drugs and vaccines against the disease has increased during the COVID-19 pandemic. Protein binding is one of the key biochemical phenomena studied during the drug development process, as the cell receptors to which antigens on the infectious agents or drug molecules attach are mostly proteinic in nature. Thus, the pharmaceutical and biotechnological companies investing in product innovations frequently need protein binding assay materials and equipment.
The global protein binding assay market is segmented on the bases of technology, end user, and geography. The market, by technology, is segmented into ultracentrifugation ultrafiltration, equilibrium dialysis, surface plasmon, and others. Based on end user, the protein binding assay market is segmented into contract research organizations, pharmaceutical and biotechnology companies, and research and diagnostic laboratories. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East and Africa, and South and Central America.
The List of Companies - Protein Binding Assay Market