The protein binding assay market is projected to reach US$ 694.63 million by 2028 from US$ 340.14 million in 2021; it is estimated to grow at a CAGR of 10.7% from 2021 to 2028.
Protein binding assays assist in analyzing the interaction between two types of proteins. These assays are widely used in the new drug development process.
The protein binding assay market is segmented on the bases of technology, end user, and geography. By geography, the market is broadly segmented into North America, Europe, Asia Pacific, the Middle East and Africa, and South and Central America. The report offers insights and in-depth analysis of the market, emphasizing on parameters such as market trends, technological advancements, and market dynamics, along with the analysis of competitive landscape of the globally leading market players.
Lucrative Regions for Protein Binding Assay Market
- Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.
- Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.
Market Insights
Growing Drug Discovery Activities Drive Protein Binding Assay Market Growth
A clinical trial is a crucial and significant step in the determination of the safety and effectiveness of a medical strategy, treatment, and device for commercial usage. These studies also help understand and determine the best medical approaches for a particular therapeutic area. Before the approval of drug molecules or medical devices by the regulatory authorities, a series of clinical studies are conducted. The increasing prevalence of communicable and non-communicable diseases is triggering the demand for the development of new drugs and medical devices, which, in turn, propels the demand for the protein binding assay. As per the data from the US National Library of Medicine, in 2018, there were ~280,801 clinical studies ongoing in 50 states and 204 countries. The following figure shows the rise in the number of studies registered in period of year 2015 to 2020.
Number of Registered Studies for Clinical Trials
Year First Posted | Studies at Start of Year | Studies During Year | Studies at End of Year |
2015 | 181,304 | 24,130 | 205,434 |
2016 | 205,434 | 27,809 | 233,243 |
2017 | 233,243 | 29,198 | 262,441 |
2018 | 262,441 | 17,836 | 280,277 |
2019 | 293,275 | 32,519 | 325,794 |
2020 | 325,794 | 36,740 | 362,534 |
Furthermore, pharmaceutical, medical device, and biotechnology companies focus on research and development (R&D) activities to develop new molecules for therapeutic applications with the greatest medical and commercial potential. The companies invest majorly in the R&Ds intending to deliver high quality and innovative products to the market.
Top 10 Pharmaceutical R&D Spenders, 2019
Name of Company (R&D Budget as % of Revenue) | Name of Company (R&D Budget as % of Revenue) |
1. F. Hoffmann La-Roche Ltd. (19.0%) | 2. Johnson & Johnson Services, Inc. (13.8%) |
3. Merck KGaA (21.1%) | 4. Novartis AG (19.8%) |
5. Pfizer, Inc. (16.7%) | 6. Sanofi S.A (16.7%) |
7. AbbVie, Inc. (19.0%) | 8. Bristol Myers Squibb Company Limited (23.6%) |
9. AstraZeneca Plc. (24.8%) | 10. GlaxoSmithKline Plc (13.8%) |
In the early stages of the drug development process, protein binding assays are being developed. Because unbound circulating drugs have the best access to targets and excretion pathways, drug candidate binding to plasma proteins is crucial for drug distribution, efficacy, and safety margin definition. According to Statista, around 7,493 drugs entered the preclinical stage in 2017, and the number is estimated to reach 8,040 in 2018. As a result, the total number of drug candidates being screened each year is increasing. Protein binding studies, which are conducted early in the drug development process, are an important aspect of the preclinical phase. Hence, the rising drug discovery activities coupled with increasing pharmaceutical R&D expenditure drives the growth of the protein binding assay market.
Rising Need of Reducing Drug Discovery and Development Costs Contributes Significantly to Protein Binding Assay Market Growth
The cost of developing new drugs remains high at an inflation-busting rate, and returns and profits on investments are declining, placing pressure on the entire innovative medicine system. Many pharmaceutical and biopharmaceutical research companies are re-evaluating old R&D policies and focusing their efforts on improving efficiency, increasing output, and satisfying unmet patient requirements due to current economic and political pressures to reduce the healthcare cost. The changing focus on drug discovery and development, and the rising use of new technologies for identifying and screening drug candidates are allowing research personnel to tap into various chronic, degenerative, and life-threatening disease segments that were previously untargeted.
Drug discovery and development is a costly process as it requires investments in funding, human resources, and technologies. Before launching a new drug in the market, strict adherence to regulations on testing and manufacturing standards is required. Furthermore, the failure of drug candidate during the development stage results in the wastage of entire investment. Protein binding studies assist in assessing binding and absorption capabilities in preclinical phases, resulting in lower drug attrition in the later stages of development, which helps optimize drug discovery expenses. Thus, rising need of reducing the cost of drug discovery and development process is fueling the protein binding assay market growth.
Technology Insights
Based on technology, the global protein binding assay market is segmented into ultracentrifugation ultrafiltration, equilibrium dialysis, surface plasmon, and others. In 2020, the equilibrium dialysis segment held the largest share of the market. However, the ultrafiltration segment is expected to register the highest CAGR in the market during 2021–2028. Equilibrium dialysis is among the most widely accepted methods for evaluating protein binding, and it can be performed with the help of rapid equilibrium dialysis (RED) devices. Researchers prefer this method as it has fewer binding effects to extraneous and unintended factors affecting research results.
End User Insights
Based on end user, the protein binding assay market is segmented into contract research organization, pharmaceutical and biotechnology companies, and research and diagnostic laboratories. The pharmaceutical and biotechnology companies segment is expected to hold the largest market share in 2021. It is also expected to be the largest shareholder in the market by 2028. These companies are the major adopters of CRO services; they approach CROs for outsourcing drug and molecule research and development. Protein binding is a fundamental biochemical process that is used to study the mechanism of drugs along with their pharmacological effects in subjects. These aspects are propelling the protein binding assay market for the market for the pharmaceutical and biotechnology companies segment.
Protein Binding Assay Market, by Technology – 2021 and 2028
- Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.
- Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.
Customize Research To Suit Your Requirement
We can optimize and tailor the analysis and scope which is unmet through our standard offerings. This flexibility will help you gain the exact information needed for your business planning and decision making.
Protein Binding Assay Market: Strategic Insights
Market Size Value in US$ 340.14 Million in 2021 Market Size Value by US$ 694.63 Million by 2028 Growth rate CAGR of 10.7% from 2021-2028 Forecast Period 2021-2028 Base Year 2021
Akshay
Have a question?
Akshay will walk you through a 15-minute call to present the report’s content and answer all queries if you have any.
Speak to Analyst
Customize Research To Suit Your Requirement
We can optimize and tailor the analysis and scope which is unmet through our standard offerings. This flexibility will help you gain the exact information needed for your business planning and decision making.
Protein Binding Assay Market: Strategic Insights
| Market Size Value in | US$ 340.14 Million in 2021 |
| Market Size Value by | US$ 694.63 Million by 2028 |
| Growth rate | CAGR of 10.7% from 2021-2028 |
| Forecast Period | 2021-2028 |
| Base Year | 2021 |
Akshay
Have a question?
Akshay will walk you through a 15-minute call to present the report’s content and answer all queries if you have any.
Speak to Analyst
Product launches, and mergers and acquisitions are highly adopted strategies by the players operating in the global protein binding assay market. A few of the recent key product developments are listed below:
In November 2020, Pharmaron Beijing Co., Limited acquired 100% assets of Absorption Systems, US, for up to US$ 137.5 million in cash. Absorption Systems is a leading scientific, non-clinical contract research organization (CRO) that provides small and large molecules, cell and gene therapies, and ocular and medical device products, among others, to pharmaceutical, biotechnology, and medical device companies; regulatory agencies; and research and testing organizations.
In April 2020, Sartorius acquired selected assets of Danaher Life Sciences successfully. The transaction was completed after obtaining the required regulatory approvals.
The pace of research and development of drugs and vaccines against the disease has increased during the COVID-19 pandemic. Protein binding is one of the key biochemical phenomena studied during the drug development process, as the cell receptors to which antigens on the infectious agents or drug molecules attach are mostly proteinic in nature. Thus, the pharmaceutical and biotechnological companies investing in product innovations frequently need protein binding assay materials and equipment.
Protein Binding Assay – Market Segmentation
The global protein binding assay market is segmented on the bases of technology, end user, and geography. The market, by technology, is segmented into ultracentrifugation ultrafiltration, equilibrium dialysis, surface plasmon, and others. Based on end user, the protein binding assay market is segmented into contract research organizations, pharmaceutical and biotechnology companies, and research and diagnostic laboratories. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East and Africa, and South and Central America.
Company Profiles
- Thermo Fisher Scientific, Inc.
- Merck KGaA
- Eurofins Scientific
- General Electric Company
- Sovicell GmbH
- Pharmaron Beijing Co., Ltd.
- Biotium, Inc.
- MicroConstants, Inc.
- Sartorius AG
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
Technology ; End User , and Geography.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States
Frequently Asked Questions
Protein binding assay is method or a procedure that assist in analyzing the interaction between two types of proteins. The protein binding assays are widely used in the process of the new drug development. The thermophoresis techniques are expected to analyze the interaction between the proteins.
Key factors driving the growth of the market are growing drug discovery activities and pharmaceutical R&D expenditure and rising pressure to reduce drug discovery and development costs are boosting the market. However, challenges with existing technologies are likely to hinder the market’s growth.
Key players in the market are Thermo Fisher Scientific, Inc., Merck KGaA, Eurofins Scientific, General Electric Company, Sovicell GmbH, Pharmaron Beijing Co., Ltd., Biotium, Inc., MicroConstants, Inc. and Sartorius AG among others.
Global protein binding assay market is segmented by region into North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. The North American region holds the largest market share of the market, whereas the Asia Pacific region is the fastest-growing region. The growth factors that are contributing to market’s growth in the North American region are growing elevation in research and development expenditures by the healthcare and life sciences companies in the region, especially in the US and Canada.
The global protein binding assay market is segmented on the bases of technology, end user, and geography. The market, by technology, is segmented into ultracentrifugation ultrafiltration, equilibrium dialysis, surface plasmon, and others. Based on end user, the protein binding assay market is segmented into contract research organizations, pharmaceutical and biotechnology companies, and research and diagnostic laboratories. The market, by geography, is broadly segmented into North America, Europe, Asia Pacific, the Middle East and Africa, and South and Central America.
Label-free receptor assays to emerge as powerful assay platform in coming years are the future trends in the global protein binding assay market.
The List of Companies - Protein Binding Assay Market
- Thermo Fisher Scientific, Inc.
- Merck KGaA
- Eurofins Scientific
- General Electric Company
- Sovicell GmbH
- Pharmaron Beijing Co., Ltd.
- Biotium, Inc.
- MicroConstants, Inc.
- Sartorius AG
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- 3.1 Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- 3.2 Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- 3.3 Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- 3.4 Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
Trends and growth analysis reports related to Protein Binding Assay Market
Aug 2021
Bioprocessing Market
Size and Forecast (2021 - 2031), Global and Regional Share, Trend, and Growth Opportunity Analysis Report Coverage: By Product (Instruments, and Consumables and Accessories), Scale of Operation (Commercial Operations and Clinical Operations), Process (Downstream Bioprocess and Upstream Bioprocess), Application (Monoclonal Antibodies, Vaccines, Recombinant Protein, Cell and Gene Therapy, and Others), End User (Biopharmaceutical Companies, Contract Manufacturing Organization, and Others), and Geography (North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa)
Aug 2021
Bioproduction Market
Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Product (Biologics and Biosimilars, Vaccines, Cell and Gene Therapies, Nucleic Acid Therapeutics, and Others), Application (Rheumatoid Arthritis, Hematological Disorders, Cancer, Diabetes, Cardiovascular Diseases, and Others), Equipment (Upstream Equipment, Downstream Equipment, Bioreactors, and Consumables and Accessories), End User (Biopharmaceutical Companies, Contract Manufacturing Organizations, and Others), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America)
Aug 2021
ELISA Diagnostic Test Market
Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Adoption (Human and Veterinary), Test Type (Sandwich ELISA, Indirect ELISA, Competitive ELISA, and Multiple & Portable ELISA), Application (Autoimmune Diseases, Infectious Diseases, Cancer Diagnosis, Protein Quantification, and Others), End User (Hospitals & Diagnostic Centers, Pharmaceutical & Biotechnology Companies, Veterinary Hospitals & Diagnostic Laboratories, and Others), and Geography (North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa)
Aug 2021
Swine Diagnostics Market
Size and Forecasts (2022 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Product Type [Immunoassays Kits, PCR Kits, Hemagglutination Inhibition (HI), and Others], Sample Type (Blood, Oral Fluids, Nasal Swabs, Tissue Samples, and Others), Disease [African Swine Fever (ASF)/Classical Swine Fever (CSF), Respiratory Diseases, Porcine Circovirus, Porcine Epidemic Diarrhea, Swine Dysentery, and Others], End User (Veterinary Hospitals, Veterinary Clinics, and Other End Users), and Geography
Aug 2021
Microbial Identification Methods Market
Size and Forecasts (2020 - 2030), Global and Regional Share, Trends, and Growth Opportunity Analysis Report Coverage: By Method (Genotypic, Phenotypic, and Proteotypic), Type (Bacterial Identification System, Microbial Enumeration System, Bacterial Resistance Identification Systems, Microbiology Analyzer, and Others), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and Latin America)
Aug 2021
Biopharmaceuticals Market
Forecast to 2028 - COVID-19 Impact and Global Analysis By Product Type (Monoclonal Antibodies, Recombinant Vaccines, Conventional Vaccines, Recombinant Growth Factors, Purified Proteins, Recombinant Proteins, Recombinant Hormones, Recombinant Enzymes, Cell & Gene Therapies, Cytokines/Interferon/Interleukins, and Others) and Application (Oncology, Inflammatory & Infectious Disease, Autoimmune Disorders, Metabolic Disorders, Hormonal Disorders & Growth Failure, Cardiovascular Diseases, Neurological Diseases, and Others)
Aug 2021
GMP Cell Therapy Consumables Market
Forecast to 2028 - COVID-19 Impact and Global Analysis by Product (Kits, Reagents/Molecular Biology Reagents, Growth Factors/Cytokines and Interleukins, and Others), Cell Therapy (NK Cell Therapy, Stem Cell Therapy, T-Cell Therapy, and Others), Process (Cell Collection and Characterization/Sorting and Separation, Cell Culture and Expansion/Preparation, Cryopreservation, Cell Processing and Formulation, Cell Isolation and Activation, Cell Distribution/Handling, Process Monitoring and Control/Readministration/Quality Assurance, and Others), and End Use (Clinical, Commercial, and Research)
Aug 2021