酶促 DNA 合成市场基于(关键地区、市场参与者、规模和份额)- 到 2031 年的预测

  • Report Code : TIPRE00027647
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 211
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[研究报告]酶法 DNA 合成市场预计将从 2022 年的 2.4096 亿美元增长到 2028 年的 22.4488 亿美元;预计 2022 年至 2028 年复合年增长率为 45.1%。

酶促 DNA 合成是一种成熟的 DNA 合成技术,可用于合成生物学、基因工程、治疗性抗体和疫苗的生产。设计和其他先进的生物程序。事实证明,它在维护 DNA 文库和合成定制 DNA 分子方面也很有用。

酶法 DNA 合成市场前景

遗传性疾病患病率上升推动酶法 DNA 合成市场增长

< 唐氏综合症、自闭症谱系障碍、癌症、糖尿病、囊性纤维化和镰状细胞性贫血是一些常见的遗传性疾病。据 Global Genes 称,已发现超过 10,000 种不同的遗传病和罕见病,约 4 亿人患有罕见病。有些遗传性疾病在出生时就会出现症状,而另一些则随着时间的推移而出现症状。遗传疾病的全球负担似乎正在增加。美国医疗机构国家生物技术信息中心(NCBI)的数据显示,2021 年 11 月,9.4% 的儿科患者被发现患有遗传性疾病,其中 44.7% 为新生儿,病情危重。此外,美国有 1317 万患者患有独特的遗传性疾病。根据美国疾病控制与预防中心 (CDC) 2022 年报告,镰状细胞性贫血影响约 10 万美国人,每 356 名非裔美国人新生儿中就有 1 人患有镰状细胞性贫血。囊性纤维化是另一种全球常见遗传病,在美国影响着大约 30,000 人,每年约有 1,000 例新病例接受治疗。酶促 DNA 合成是一种成熟的 DNA 合成技术,可用于合成生物学、基因工程和治疗性抗体研究。 DNA 合成与酶检测一起显示出更大的诊断可能性。这种方法提供了有关高危人群的重要信息,并帮助他们做出有关疾病诊断和药物治疗的重要决定。因此,随着遗传性疾病在全球范围内的日益流行,人们越来越意识到早期检测这些遗传缺陷的必要性,从而推动酶法DNA合成市场的增长。

战略视角;

高成本和复杂的流程阻碍了酶法DNA合成市场的增长

酶法DNA合成技术还不够成熟,在广泛应用之前需要进一步优化。大多数基于天然酶末端脱氧核苷酸转移酶 (TdT),该酶在生物系统中用于向 DNA 序列添加新碱基。基于 TdT 的方法代表了对化学程序的改进,因为它避免了危险废物的产生。但该酶成本高、精度低,难以用于体外DNA合成。 TdT 酶过于宽松,会比应有的情况更频繁地添加错误碱基。因此,基于 TdT 的寡核苷酸具有更多序列错误,可能需要相同甚至更多的合成后质量控制步骤,从而增加了合成过程的时间和成本。在使用这种酶时,科学家需要添加更多试剂来构建目标序列,这进一步增加了整个合成过程的成本。通过TdT获得的合成DNA的每个碱基的成本远高于常规合成的遗传材料。因此,高成本和复杂的程序限制了酶促DNA合成市场的增长。

基于产品类型的信息

根据产品类型,酶促DNA合成市场被细分分为:定制DNA合成和DNA文库合成。 DNA 文库合成细分市场在 2021 年占据最高市场份额。此外,预计定制 DNA 合成细分市场在预测期内(2022-2028 年)复合年增长率最高。

< h3>酶促 DNA 合成市场,由产品:2021年和2028年

基于应用的见解

根据应用,酶法DNA合成市场DNA分为合成生物学、基因工程和治疗性抗体。 、疫苗设计等应用。合成生物学领域在 2021 年占据最大的市场份额。用于治疗性抗体应用的酶 DNA 合成市场预计在预测期内将以最高复合年增长率增长。

基于最终用户的信息

根据最终用户,酶促 DNA 合成市场分为学术界和学术界。研究机构、生物技术和制药公司、诊断实验室等。生物技术与2021 年,制药公司细分市场占据最大市场份额。学术和商业领域;预计研究机构领域在预测期内(2022-2028 年)将实现市场上最高的复合年增长率。

基于技术的信息

基于技术,酶促 DNA 合成市场分为 SOLA、CRISPR、PCR 等。 PCR 领域在 2021 年占据最大份额,预计在预测期内将持续类似的趋势。另一方面,预计 CRISPR 领域的复合年增长率在预测期内最高。

公司在 DNA 酶合成市场的并购中主要采用的策略。主要市场参与者的一些最新进展如下:

  • 2022年4月,金斯瑞在全球年度Built With Biology会议上推出了业界首款用于DNA合成的最高性能半导体芯片。这款高密度 DNA 合成芯片采用金斯瑞专有的微型半导体芯片技术开发,可同时合成 840 万个独特的寡核苷酸。
  • 2022 年 4 月,Evonetix Ltd 因其专利热控制技术获得专利 EP3551331B1。用于 DNA 合成,以及在欧洲设计和制造硅芯片。除了扩大 Evonetix 的知识产权组合之外,该专利还被视为该公司开发桌面 DNA 合成平台战略的关键一步。
  • 2022 年 3 月,Molecular Assemblies , Inc. 筹集了美国 B 轮融资新投资者 Casdin Capital 以及所有主要 A 轮投资者:Agilent Technologies、iSelect Fund、Codexis、LYFE Capital 和 Argonautic Ventures 参与了 2580 万美元的投资。该公司打算利用融资所得资金启动一项针对关键客户的计划,并推动该公司专有的全酶 DNA 合成技术走向早期商业化。
  • 2021 年 11 月,DNA Script 获得了 220 万美元的资助来自美国国立卫生研究院 (NIH) 国家人类基因组研究所 (NHGRI) 的资助,支持开发能够酶促打印 DNA 和 RNA 合成物的下一代打印机。

公司简介

  • Telesis Bio Inc
  • Evonetix
  • Ansa Biotechnologies, Inc.
  • Evonetix
  • Ansa Biotechnologies, Inc.
  • Evonetix
  • Ansa Biotechnologies, Inc.
  • li>
  • Camena Bio
  • 金斯瑞生物科技公司
  • 分子组装
  • DNA Script
  • 触摸灯
  • < li>Synbio Technologies
  • Twist Bioscience
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

This text is related
to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

This text is related
to country scope.

Frequently Asked Questions


Which region is projected to be the fastest-growing region in the global enzymatic DNA synthesis market?

The Asia Pacific region is expected to be the fastest-growing region in the enzymatic DNA synthesis market over the forecast period due to increasing government investment to provide healthcare facilities, growing advancements in healthcare infrastructure, greater adoption of advanced technologies, and rising healthcare spending in countries such as China, Japan, and India.

What are the growth estimates for the enzymatic DNA synthesis market till 2028?

The enzymatic DNA synthesis market is expected to be valued at US$ 2,244.88 million in 2028.

Which segment by product type led the enzymatic DNA synthesis market?

The DNA library synthesis segment held the largest share of the market in 2022, owing to the various advantages offered by DNA library synthesis such as systematic, unbiased investigations such as high-throughput screening for discovery biology, directed evolution for protein engineering, and in vitro molecular optimization to generate mutant proteins with improved or novel properties. However, the custom DNA synthesis segment is estimated to register the highest CAGR in the market during the forecast period.

What is the estimated enzymatic DNA synthesis market size in 2022?

The enzymatic DNA synthesis market is estimated to be valued at US$ 240.96 million in 2022.

What is the market CAGR value of the enzymatic DNA synthesis market during the forecast period?

The CAGR value of the enzymatic DNA synthesis market during the forecasted period of 2022-2028 is 45.1%.

Who are the major players in the enzymatic DNA synthesis market across the globe?

The enzymatic DNA synthesis market majorly consists of the players, such as Telesis Bio Inc, Evonetix, Ansa Biotechnologies, Inc., Camena Bio, GenScript Biotech Corp., Molecular Assemblie, DNA Script, Touchlight, Synbio Technologies, and Twist Bioscience.

What are the driving factors for the global enzymatic DNA synthesis market across the world?

The factors that are driving the growth of the enzymatic DNA synthesis market are the rising prevalence of genetic disorders and surging number of product launches. Also, the growing demand for enzymatic DNA synthesis procedures is expected to provide opportunity for the enzymatic DNA synthesis market in forecasted period.

What is enzymatic DNA synthesis?

Enzymatic DNA synthesis (EDS) offers significant advantages in terms of accessibility and convenience, changing the pace and control of iteration and innovation with less environmental impact. The enzymes involved in DNA replication act coordinated to synthesize both leading and lagging strands of DNA simultaneously at the replication fork. Purported benefits of enzymatic synthesis include the ability to avoid the use of harsh chemical substances (which often result in toxic waste) and an ever-increasing ability to produce longer and longer strands of DNA, which in turn not only leads to a "more green" form of DNA synthesis, but also some incredibly powerful new uses for the longer DNA chains (e.g., vaccines, therapeutics, and data storage).

The List of Companies - Enzymatic DNA Synthesis Market

  1. Telesis Bio Inc       
  2. Evonetix                 
  3. Ansa Biotechnologies, Inc.               
  4. Camena Bio           
  5. GenScript Biotech Corp.    
  6. Molecular Assemblies       
  7. DNA Script              
  8. Touchligh
  9. Synbio Technologies          
  10. Twist Bioscience

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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