[研究报告] 小鼠模型市场预计将从2022年的17.057亿美元增长到2028年的23.409亿美元;预计 2022 年至 2028 年复合年增长率为 5.4%。
分析师观点:
小鼠模型在临床前试验过程中的药物发现过程中发挥着至关重要的作用。例如,用于临床前试验的小鼠模型证明了新药的代谢和吸收具有一般的安全性和有效性。此外,具有相关疾病症状的小鼠品系提供了一种初级、有效且高效的模型,在药物发现中发挥着重要作用。针对临床前药物发现过程的小鼠模型的主要目的是因为小鼠具有与人类相似的基因组水平和疾病病理生理学。因此,这种功能的组合为研究人员提供了一个独特的强大工具来了解人类疾病的机制和测试新的药物疗法。小鼠模型在病毒学和传染病中的使用不断增加,以及用于研究人源化小鼠模型的个性化医疗的消费不断增长,是预测期内小鼠模型市场增长的最大影响因素。
市场动态
增长小鼠模型在病毒学和传染病中的应用促进了小鼠模型市场的增长
小鼠模型是研究传染病发病机制的重要工具以及针对各种人类病原体的疫苗和疗法的临床前评估。使用基因定义的近交小鼠品系、人源化小鼠和基因敲除小鼠,使研究界能够研究病原体如何引起疾病,并解释特定宿主基因在控制或促进疾病中的作用。它还有助于确定潜在的预防目标或确定各种传染源的治疗方法。随着新型传染病的出现,动物模型已成为研究疾病机制和开发治疗方法的重要工具。
异种移植人类免疫系统的小鼠已被用来研究各种传染源的发病机制,包括恶性疟原虫(疟疾)、结核分枝杆菌、登革热病毒和流感病毒。这些模型有助于研究艾滋病毒,包括分析促进病毒复制的病毒和宿主因素以及艾滋病毒与宿主免疫反应的相互作用。它们还可以作为测试控制或治愈 HIV 感染的治疗方法的平台。
小鼠模型因其可重复性、低成本而被广泛用于疫苗/疗法的临床前筛选。 ,并且易于实验操作。过去一个世纪,疫苗、抗生素/抗病毒药物和感染控制措施的进步显着减轻了传染病对公共卫生的负担。然而,多年来传染性病毒性疾病有所增加。过去二十年,冠状病毒爆发过3次——2002年的SARS-CoV、2012年的中东呼吸综合征冠状病毒(MERS-CoV)和2019年的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。然而,当前的 SARS-CoV-2 比 2002 年的 SARS-CoV 严重得多,已传播到超过 213 个国家,影响了数百万人。 2019年新型冠状病毒病(COVID-19)的出现促使动物模型研究开发出有效的治疗方法。
除了冠状病毒研究之外,小鼠模型也正在研究中。被认为是测试乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、寨卡病毒和巨细胞病毒(CMV)的最佳小动物模型。据世界卫生组织称,每年有超过 1700 万人死于传染病。近20年来,出现了30多种新的传染病。据联合国艾滋病规划署统计,截至2019年底,已有3800万人受到艾滋病毒影响。小鼠模型因其体积小、成本低、易于使用、重复性高等特点,被广泛用于各种病毒研究。
战略洞察
未来趋势
基因编辑工具不断进步
“全球小鼠模型市场”根据类型、服务、技术、指示、模式、应用、最终用户和地理位置进行细分。根据类型,小鼠模型市场分为近交系小鼠、基因工程小鼠、杂交小鼠、自发突变小鼠、远交系小鼠和手术改造小鼠。根据服务,小鼠模型市场分为饲养、冷冻保存、基因检测、模型许可、检疫等。按技术划分,小鼠模型市场分为 CRISPR、显微注射、核移植、胚胎干细胞注射等。根据情况,小鼠模型市场分为肿瘤学研究、遗传学研究、传染病研究、内分泌代谢研究、纤维化、中枢神经系统(CNS)研究、免疫学和炎症研究、心血管研究和其他疾病研究。按模式划分,鼠标模型市场分为外包和内部两种。按应用划分,小鼠模型市场分为临床前药物开发、生物标志物分析和基础癌症研究。按最终用户划分,小鼠模型市场分为学术型和商业型。研究机构、制药及生物技术公司、合同研究组织等。基于地理位置的小鼠模型市场分为北美(美国、加拿大和墨西哥)、欧洲(德国、法国、意大利、英国、俄罗斯和欧洲其他地区)、亚太地区(澳大利亚、中国、日本、印度、韩国、亚太地区其他地区)、中东和美国非洲(南非、沙特阿拉伯、阿联酋以及中东和非洲其他地区)以及南美和非洲中美洲(巴西、阿根廷以及南美洲和中美洲其他地区)
细分分析:
根据技术,小鼠模型市场分为CRISPR、显微注射、核移植、胚胎干细胞注射等。到 2022 年,CRISPR 细分市场将占据更大的市场份额,并淘汰其他市场份额最少的细分市场。 CRISPR 的扩展形式是成簇的规则间隔短回文重复序列。 CRISPR 是一种高度精确的基因编辑工具,可以改变小鼠和人类的研究格局。 CRISPR 对大多数小鼠品系都有效;因此,新的突变可以在选择的遗传背景中直接产生。因此,该技术的优化和有效使用消除了从一种遗传背景到另一种遗传背景的回交突变的需要、时间和资源,这是通过传统方法产生突变小鼠时的典型做法。
此外,该技术的小鼠模型可用于了解疾病表现和潜在疗法。例如,2021 年 Springer Nature Limited 发表的一项题为“体内碱基编辑拯救小鼠 Hutchinson –Gilford 早衰综合症”的研究表明,使用源自 CRISPR 的“碱基编辑器”进行基因治疗可延长早衰小鼠的寿命。哈钦森-吉尔福德早衰综合症(早衰症)是一种极其罕见的进行性遗传性疾病,会导致儿童从出生的头两年开始迅速衰老。患有早衰症的儿童出生时通常表现正常。因此,在小鼠模型中越来越多地使用该技术来操纵或编辑核酸材料预计将有助于该细分市场的增长。
小鼠模型市场,按类型2022年和2030年
根据适应症,小鼠模型市场分为肿瘤学研究、遗传学研究、传染病研究、内分泌研究代谢研究、纤维化、中枢神经系统 (CNS) 研究、免疫学和炎症研究、心血管研究和其他疾病研究。预计肿瘤学研究领域将在 2022 年占据小鼠模型市场的最大份额,并预计在预测期内复合年增长率最高为 6.1%。小鼠癌症模型使研究人员能够了解复杂且动态的生理系统中的肿瘤生物学。转移是一个复杂的过程,涉及一系列步骤,其中癌细胞离开原始肿瘤部位并通过血流或淋巴系统转移到其他身体部位。由于转移是癌症死亡的主要原因之一,因此有必要确定转移的关键遗传事件
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
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Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
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Frequently Asked Questions
Increased use of mice model in virology, infectious disease, and others along with rising demand for personalized medicine and increase in R&D activities are expected to drive the mice model market.
Global mice model market is segmented by region into North America, Europe, Asia Pacific, the Middle East & Africa, and South & Central America. In North America, the U.S. held the largest market for mice model market in 2022. The US is expected to hold the highest share in the mice model market during the forecast period. The presence of top players, presence of contract research organizations and the increase in preclinical activities by various pharmaceutical companies are the contributing factors for the regional growth. Additionally, increase in technological advancement along with surge in R&D activities are the key factor responsible for the Asia-Pacific regional growth.
Based on type, inbred mice segment held the largest share in 2022 and is expected to continue to do so till the forecast period.
A mice model is specially designed and produced in the laboratory for the study of various diseases and their treatment. The mice models are useful as they exhibit mammalian features like humans and also suffer from the various disease which are the same as humans.
The preclinical drug development segment dominated the global mice model market and is expected to account for the largest revenue of US$ 1,149.32 Mn by 2028.
Charles River Laboratories; The Jackson Laboratory; Taconic Biosciences; TRANS GENIC INC.; GenOway S.A.; Envigo; Janvier Labs; Ozgene Pty Ltd.; Crown Bioscience Inc.; Harbour BioMed are among the leading companies operating in the global mice model market
The List of Companies - Mice Model Market
- Charles River Laboratories
- The Jackson Laboratory
- Taconic Biosciences
- TRANS GENIC INC.
- GenOway S.A.
- Envigo
- Janvier Labs
- Ozgene Pty Ltd.
- Crown Bioscience Inc.
- Harbour BioMed
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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