制药 ADMET 检测市场预计将从 2021 年的 67.8306 亿美元增长到 2028 年的 135.7862 亿美元;预计 2022 年至 2028 年的复合年增长率为 10.5%。
产品批准和上市数量的增加推动了市场的增长。制药 ADMET 测试市场由主要竞争参与者组成,他们采用各种策略,包括产品发布、地域扩张和技术进步。以下列出了市场的一些最新发展:
- 2021 年 12 月,Discovery Life Sciences 宣布收购 In Vitro ADMET Laboratories (IVAL),以利用世界上最大的肝细胞库存和世界知名的科学领袖的能力。马里兰州的 IVAL 提供生理上准确的体外实验系统,以提高制药行业毒理学、药理学和药物代谢测试的有效性。
- 2022 年 4 月,拥有生物样本和生物标志物专家的 Discovery Life Sciences 公司宣布收购康宁公司生命科学部门的 Gentest 业务部门。Gentest 将并入 Discovery Life Sciences 最近收购的 In Vitro ADMET Laboratories, LLC (IVAL)。这将使 Discovery 成为制药和生命科学行业体外药物试验系统的知名供应商。
- 2021 年 10 月,专门从事分子诊断的公司 Genetic Analysis AS (GA) 宣布与 Eurofins ADME BIOANALYSES 达成服务协议,Eurofins ADME BIOANALYSES 是一家合同研究组织 (CRO),为制药行业提供药代动力学、药效学和药物代谢领域的一系列服务。
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制药 ADMET 测试市场:
复合年增长率(2021 - 2028 年)10.5%- 2021 年市场规模
67.8 亿美元 - 2028 年市场规模
135.8 亿美元
市场动态
- 財政部
- 財政部
- 財政部
- 財政部
- 財政部
- 財政部
- 財政部
- 財政部
- 財政部
关键人物;主力;重要一员
- 华商国际控股有限公司
- 查尔斯河实验室
- 无锡药明康德
- 普洛麦格公司
- 默克集团
- 安捷伦科技公司
- Biovia(达索系统)
- 塞浦路斯有限公司
- Bio-Rad 实验室有限公司
区域概况
- 北美
- 欧洲
- 亚太
- 南美洲和中美洲
- 中东和非洲
市场细分
- 体内 ADMET 测试
- 体外 ADMET 测试
- 计算机模拟 ADMET 测试
- 细胞培养
- 高吞吐量
- 分子成像
- OMICS 技术
- 全身毒性
- 肾毒性
- 肝毒性
- 神经毒性
- 其他的
- 示例 PDF 通过定性和定量分析展示了内容结构和信息的性质。
市场参与者积极参与产品创新和开发,加上产品批准数量的增加,推动了制药 ADMET 检测市场的增长。此外,随着先进技术的出现,市场在预测期内将呈指数级增长。
ADMET 测试研究的高成本阻碍了制药 ADMET 测试市场的增长。根据国会预算办公室 2021 年的报告《制药业的研究与开发》,开发一种新药的预计成本可能在不到 10 亿美元到超过 20 亿美元之间,包括资本支出和治疗成本(对于使用未上市药物的患者)。制药行业在 2019 年投入了 830 亿美元用于研发。这些支出包括发现和测试新药、开发产品扩展等渐进式创新以及出于安全监测或营销目的的临床测试所产生的成本。这一金额约为该行业在 1980 年代每年花费的 10 倍。由于发现和开发新药的不可预测性和高成本,只有约 12% 的经过临床试验的药物最终获得 FDA 批准上市。这些因素阻碍了全球制药 ADMET 测试市场的增长。
区域概况
亚太地区是药品 ADMET 检测市场复合年增长率最高的地区。毒理学检测产品和精准药物的需求旺盛、药物发现的增加以及主要市场参与者对研发的投资增加是推动亚太市场增长的因素之一。由于中国患有慢性疾病的人口不断增加,导致对个性化医疗的需求,中国的药品 ADMET 检测市场正在扩大。由于各机构和组织支持推广药物的体外 ADMET 测试,中国的药物发现正在蓬勃发展。例如,体外科学研究所 (IIVS) 与国际政府合作,帮助他们实施非动物测试方法来监管产品和成分。2019 年 4 月,IIVS 认可中国国家药品监督管理局 (NMPA) 接受某些非动物(替代)测试方法用于化妆品监管。
此外,在中国制药 ADMET 检测市场运营的主要参与者正在采取有机和无机战略,以扩大其在亚太地区的产品组合和影响力。例如,2022 年 6 月,药明康德和吴根公司宣布合作生产吴根的 WU-NK-101,这是一种利用记忆自然杀伤 (NK) 细胞的力量治疗癌症的新型免疫疗法。根据合作协议,药明康德同意为 WU-NK-101 提供制造和测试服务,以便将创新的细胞治疗产品交付给癌症患者。
由于对药物安全数据的重视程度不断提高、对卫生经济学和结果研究的新需求以及向个性化医疗和孤儿药开发的转变,韩国的药物 ADMET 检测市场正在逐渐增长。根据全球和地区供应商的可用性、患者库以及该国当前的监管情况,韩国被认为是最具吸引力的早期目的地。相对于亚洲其他地区,甚至相对于世界其他地区,韩国对 I-IIa 期研究的兴趣和增长与以下因素直接相关:
- 韩国政府投资发展生物技术产业
- 对早期临床研究感兴趣的受过高等教育的医疗和科研人员
- 接触患者并注重质量
- 不断扩展的 IT 基础设施。
上述因素正在推动韩国多家 CRO 的扩张。此外,韩国宣布启动一项 5 年计划,以推进临床试验并提升该国作为全球研究目的地的地位。2019 年,Novotech 公司宣布与韩国两家主要医院建立合作伙伴关系,以加强 Novotech 在韩国的临床服务能力。这些因素预计将在预测期内推动亚太地区制药 ADMET 检测市场的增长。
应用程序洞察
根据应用,全球药物 ADMET 测试市场细分为全身毒性、肾毒性、肝毒性、神经毒性等。预计全身毒性部分在预测期内将占据最大的市场份额。药物 ADMET 测试用于识别或发现药物分子对体内器官的毒性作用。如果药物分子有毒,则可能导致全身毒性或器官毒性。全身毒性会影响整个身体或许多器官,而不是特定部位。ADMET 测试可用于执行支持整体药物发现活动的不同化学、药理学和基因测试,包括药物试验、药物设计和其他药物相互作用。此外,有几种药物类别和药物分子会导致全身毒性。局部麻醉药全身毒性 (LAST) 是一种危及生命的不良事件,可能在通过多种途径施用局部麻醉药后发生。局部麻醉技术在各种医疗环境中的使用日益广泛,这使得当代对 LAST 的理解变得高度相关。此外,制药 ADMET 测试在识别分子毒性并在临床前药物开发阶段解决它方面起着关键作用。2022 年 2 月在 Springer Nature 上发表的一项题为“用于预测急性全身毒性的计算机模型”的研究揭示了基于结构的计算模型在评估急性全身毒性方面可用且可能有用的用途。
预计肝毒性部分将在预测期内实现最高的复合年增长率。肝毒性是药物对肝脏造成的损伤或损害。这是一种已知的严重药物不良反应。此外,药物引起的肝毒性是药物开发过程中人员流失的主要原因。体外三维 (3D)细胞培养比传统的 2D 单层模型能够更好地重现复杂的体内微环境。因此,使用这种先进的模型研究肝毒性预计将在 2021-2028 年推动该细分市场的制药 ADMET 检测市场增长。
在制药 ADMET 测试市场运营的公司采用产品创新战略来满足全球不断变化的客户需求,这也使他们能够在市场上保持自己的品牌名称。
制药 ADMET 测试市场报告范围
报告属性 | 细节 |
---|---|
2021 年市场规模 | 67.8亿美元 |
2028 年市场规模 | 135.8亿美元 |
全球复合年增长率(2021 - 2028) | 10.5% |
历史数据 | 2019-2020 |
预测期 | 2022-2028 |
涵盖的领域 | 按测试类型
|
覆盖地区和国家 | 北美
|
市场领导者和主要公司简介 |
|
- 示例 PDF 通过定性和定量分析展示了内容结构和信息的性质。
全球制药 ADMET 测试市场 – 细分
制药 ADMET 检测市场根据检测类型、技术、应用和地理位置进行细分。根据检测类型,市场分为体内 ADMET 检测、体外 ADMET 检测和计算机模拟 ADMET 检测。根据技术,市场分为细胞培养、高通量、分子成像和 OMICS 技术。根据应用,全球制药 ADMET 检测市场分为全身毒性、肾毒性、肝毒性、神经毒性和其他。按地理位置划分,市场分为北美(美国、加拿大和墨西哥)、欧洲(英国、德国、法国、意大利、西班牙和欧洲其他地区)、亚太地区(中国、日本、印度、澳大利亚、韩国和亚太其他地区)、中东和非洲(阿联酋、沙特阿拉伯、南非和中东和非洲其他地区)以及南美洲和中美洲(巴西、阿根廷和南美洲和中美洲其他地区)。
公司简介
- 华商国际控股有限公司
- 查尔斯河实验室
- 药明康德
- 普洛麦格公司
- 默克公司
- 安捷伦科技公司
- Biovia(达索系统)
- 塞浦路斯有限公司
- Bio-Rad 实验室
- IQVIA 公司
- Historical Analysis (2 Years), Base Year, Forecast (7 Years) with CAGR
- PEST and SWOT Analysis
- Market Size Value / Volume - Global, Regional, Country
- Industry and Competitive Landscape
- Excel Dataset
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
This text is related
to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
This text is related
to country scope.
Frequently Asked Questions
CMIC HOLDINGS Co., LTD; Charles River Laboratories; WuXi AppTec; Promega Corporation; MERCK KGaA; Agilent Technologies, Inc.; Biovia (Dassault Systèmes); Cyprotex Limited; Bio-Rad Laboratories, Inc.; and IQVIA Inc. are among the leading companies operating in the global pharma ADMET testing market.
Based on testing type, the market is segmented into in vivo ADMET testing, in vitro ADMET testing, and in silico ADMET testing. In vivo ADMET testing segment is anticipated to hold a larger share in 2022 and is expected to continue to do so during the forecast period.
High rate of late-stage drug failure and the increasing number of product approvals and launches are the most significant factors responsible for the overall market growth.
ADMET testing expands as for absorption, distribution, metabolism, elimination, and toxicology testing of the drug molecule. These drug tests define the impact of a specific drug or chemical on human tissues. Toxicology testing is an important phenomenon before introducing new medicine to the market. ADMET testing facilitates pharmaceutical manufacturing companies to minimize their drug discovery time, and testing complications, and reduce the cost of drug development.
Trends and growth analysis reports related to Life Sciences : READ MORE..
The List of Companies - Pharma ADMET Testing Market
- CMIC HOLDINGS Co., LTD
- Charles River Laboratories
- Wuxi AppTec
- Promega Corporation
- MERCK KGaA
- Agilent Technologies, Inc.
- Biovia (Dassault Systèmes)
- Cyprotex Limited
- Bio-Rad Laboratories, Inc.
- IQVIA Inc.
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
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As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
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Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
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- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.