镰状细胞病治疗市场基于(关键地区、市场参与者、规模和份额)- 到 2030 年的预测

  • Report Code : TIPRE00030312
  • Category : Pharmaceuticals
  • Status : Published
  • No. of Pages : 245
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【研究报告】2022年镰状细胞病治疗市场价值为11.6016亿美元,预计到2030年将达到46.9187亿美元;预计 2022 年至 2030 年复合年增长率为 19.1%。
市场洞察和分析师观点:
镰状细胞性贫血是一组影响血红蛋白的疾病,血红蛋白是在全身组织和器官中输送氧气的分子。发生这种疾病时,红细胞呈新月形或新月形,患者会出现贫血。镰状细胞病 (SCD) 是一种遗传性疾病,可以通过药物控制症状和姑息治疗进行治疗。输血、骨髓移植和药物是最常见的治疗选择。尽管骨髓移植是唯一可能治愈的治疗方法,但仅推荐用于有限比例的患者。市场上只有两种 FDA 批准的药物:羟基脲和 Endari。
各国政府和私人组织越来越多地采取措施治疗这种疾病,预计将在未来几年推动镰状细胞病治疗市场的发展。例如,根据世界卫生组织2022年8月发布的数据,一些非洲卫生部长发起了一项运动,以提高认识并加强预防和护理,以减少镰状细胞性贫血(该地区最常见的疾病之一)的发病率,然而,这并没有得到足够的重视。消息人士还表示,全球1.2亿镰状细胞病患者中,超过66%生活在非洲。因此,镰状细胞性贫血的高患病率和提高对该疾病治疗的认识活动是一些关键的市场驱动因素。
增加镰状细胞性贫血领域的研究和开发也可以提振市场。例如,2022 年 5 月,Global Blood Therapeutics (GBT) 针对镰状细胞病 (SCD) 的实验性口服疗法 GBT601 每日多次服用,在一项 I 期临床试验中,六名患者的耐受性良好,并显示出有希望的药理学和疗效信号。因此,镰状细胞性贫血患病率不断上升、意识活动不断加强以及研发活动激增等因素预计将推动市场增长。然而,高昂的治疗成本阻碍了市场增长。
增长动力和挑战:
镰状细胞病(SCD)的治疗计划可分为两类:维持健康和治疗并发症。镰状细胞性贫血具有基于血红蛋白基因独特突变的基因型和表型变异。该疾病在全球范围内发病率很高,而且严重程度也在上升。据世界卫生组织称,世界上大约5%的人口具有抑制血红蛋白疾病(如镰状细胞性贫血和地中海贫血)的基因。根据国家医学图书馆发表的一项关于镰状细胞病的研究,每年有超过 300,000 名婴儿出生时患有严重的血红蛋白疾病;此外,预计到 2050 年将有 40 万新生儿患有镰状细胞病。此外,根据美国血液学会 2023 年发布的报告,估计美国患有 SCD 的人数约为 7 万至 10 万。因此,全球不同地区疟疾和镰状细胞病患病率的上升推动了镰状细胞病治疗市场的增长。此外,全球镰状细胞病高发国家的政府正在采取各种策略,通过改善人民获得医疗保健服务的机会(包括治疗选择)来根除该疾病。
SCD 治疗的药物疗法包括:羟基脲和一些品牌药物。羟基脲被认为是疾病的一线治疗方法,并受到许多医学专家的推荐。然而,全球发展中国家缺乏治疗选择。据美国血液学会称,撒哈拉以南非洲地区每年约有 300,000 名婴儿出生时患有 SCD。尽管世界卫生组织将羟基脲添加到儿童基本药物标准清单中,但在许多发展中地区仍然无法获得。此外,这种药物在非洲被认为非常昂贵。治疗 SCD 的输血还取决于是否有献血者;尽管可以获取献血者,但筛查不充分仍存在导致输血传播感染增加的风险。此外,非洲国家负责改善卫生设施和护理 SCD 患者的公共和私人医疗保健人员有限。因此,缺乏 SCD 治疗方案正在阻碍镰状细胞病治疗市场的增长。
战略见解
报告细分和范围:
镰状细胞病治疗市场根据治疗进行分类,给药途径和分销渠道。按治疗方法,市场分为仿制药和原研药。镰状细胞病治疗市场按给药途径分为口服和肠胃外。从分销渠道来看,镰状细胞病治疗市场分为直接招标、医院药房、零售药店、网上药店等。镰状细胞病治疗市场根据地理位置分为北美(美国、加拿大和墨西哥)、欧洲(法国、德国、意大利、英国、西班牙、比荷卢经济联盟、奥地利和欧洲其他地区)、亚太地区(澳大利亚、中国、日本、印度、韩国、马来西亚、印度尼西亚和亚太地区其他地区)、中东和非洲(沙特阿拉伯、阿联酋、南非、肯尼亚、坦桑尼亚、卢旺达、尼日利亚、加纳、乌干达、安哥拉、喀麦隆) 、塞内加尔、赞比亚以及中东和非洲其他地区)以及南美洲和中美洲(巴西、阿根廷以及南美洲和中美洲其他地区)
细分分析:
根据治疗,镰状细胞病治疗市场分为原研药和仿制药。 2022 年,原创者细分市场占据了更大的市场份额。此外,预计该细分市场在预测期内将录得更高的复合年增长率。根据给药途径,镰状细胞病治疗市场分为口服和肠胃外。 2022年,口腔细分市场将占据更大的市场份额。此外,预计该细分市场在预测期内将录得更高的复合年增长率。口服给药是最理想、最合适的给药途径,因为它具有较高的患者依从性、无创性、最少的无菌限制、成本效益、剂型设计的灵活性以及制造过程的简便性。易于给药和长期成本效益等优点是推动口服药物采用的主要因素。胶囊、片剂和其他口服药物的低制造成本推动了镰状细胞病治疗市场的增长。
按分销渠道,镰状细胞病治疗市场分为直接招标、医院药房、零售药房、网上药房、和别的。 2022年,直接招标领域占据最大市场份额。然而,预计在线药店领域在预测期内将创下最高复合年增长率。招标是履行特定职责或提供固定金额物品的要约。在此招标程序的第一步中,承包商将被要求提交密封的施工标书或在特定时限内提供特别计划的服务或产品。印度的电子招标程序旨在确保政府或特定客户的工作及时完成。例如,一些地方可能有具体的采购法规,规定了决策方式和接受哪些投标。网上药店是这个时代最发展的药店之一。在这种处方模式下,处方是在线生成的。在线药店的优势包括比零售店更优惠的定价,交易量低、易于获取以及更好的消费者合规性。网上药店上门提供药品,并提供医疗警报和许可药房产品的折扣。在线服务的发展、互联网的使用以及对非处方药产品自我治疗的认识是促进在线药房销售增长的重要因素。关于初级治疗和药物的教育将刺激市场发展。
镰状细胞病治疗市场,按给药途径 - 2022 年和 2030 年
区域分析:
根据地理位置,镰状细胞病治疗市场分为五个关键地区——北美、欧洲、亚太地区、南美洲和中美洲以及中东和非洲。对北美市场的分析主要集中在三个主要国家——美国、加拿大和墨西哥。 2022年,中东和非洲在镰状细胞病治疗市场中占据最大份额。可支配收入的增加、对针对性营养的需求不断增长、对镰状细胞病治疗和补充剂的认识不断提高是推动市场增长的几个重要因素。
尼日利亚的镰状细胞病治疗市场在 2022 年占据最大的市场份额,并且很可能成为预测期内增长最快的市场。据报道,在尼日利亚,患有 SCD 的儿童由于 SCD 的身体影响而无法上学,并且学业成绩不佳。根据国家医学图书馆发表的一项题为“镰状细胞病的负担”的研究,镰状细胞性贫血影响着尼日利亚 100 万人中的 20000 多人。根据国家医学图书馆发表的一项题为“镰状细胞病对尼日利亚受影响个体的影响”的研究,尼日利亚被认为是撒哈拉以南非洲地区镰状细胞贫血症发病率最高的国家,影响了 2-3% 的人。人口。据世界卫生组织和尼日利亚卫生部称,该国总人口的 25% 是导致遗传性疾病的突变基因的携带者。根据美国之音发表的《尼日利亚镰状细胞倡导者敦促当局采取坚定干预措施》一文,估计每年有 10 万名儿童被诊断出患有这种疾病,其中高达 80% 的尼日利亚儿童在 5 岁之前死亡。 5.
镰状细胞病治疗市场未来趋势:
扩大新药和疫苗研发管线
新药研发被认为是最佳策略;因此,SCD 药物/疫苗管道变得越来越强大。公私合作伙伴关系正在加速与镰状细胞病治疗相关的研究活动。
下表列出了一些正在临床开发中的 SCD 药物/疫苗:
正在研发的镰状细胞病药物/疫苗/化合物临床开发
药物
开发商
临床试验阶段
Inclacumab
辉瑞
III期
Voxelotor
辉瑞
III期
GBT021601
辉瑞
二期
PF-07209326
辉瑞
二期
RG6107
罗氏
二期
GSK4172239D
GSK
一期
BEAM –101
Beam Therapeutics
I/II 期
HGB-206
Bluebird Bio, Inc.
I/II 期
HGB-210
Bluebird Bio, Inc.< III期
ALXN1820
Alexion
II期
NCT05714969
武田药品工业株式会社
2b期
NCT03997760
武田药品工业株式会社
I期
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

This text is related
to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

This text is related
to country scope.

Frequently Asked Questions


Which route of administration segment led the sickle cell disease treatment market?

Based on route of administration, the oral segment took the forefront leaders in the worldwide sickle cell disease market by accounting largest share in 2022 and is expected to continue to do so till the forecast period.

Who are the key players in the sickle cell disease treatment market?

Answer: - Novartis AG, Pfizer Inc, Emmaus Life Sciences Inc, Teva Pharmaceutical Industries Ltd., Bristol-Myers Squibb Company, Siklos, Mylan NV, Taj Pharmaceuticals Limited, and Apotex among others are among the leading companies operating in the sickle cell disease treatment market.

What are the driving factors for the sickle cell disease treatment market across the globe?

Increasing prevalence of sickle cell disease and government and private sector's initiative to raise awareness about sickle cell disease are the most significant factors responsible for the overall market growth.

What is the regional market scenario of the sickle cell disease treatment market?

Sickle cell disease treatment market is segmented by countries comprising of North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America

What is meant by the sickle cell disease treatment market?

Sickle cell disease (SCD) is the most common inherited blood disorder that affects the red blood cells. Treatments for SCD can relieve pain and help prevent complications related with the disease. SCD is identified with a simple blood test. In addition, SCD can be detected while the baby is in the womb. Diagnostic tests such as amniocentesis and chorionic villus sampling are done before the baby is born, which helps to check the chromosomal or genetic abnormalities in the baby. A bone marrow transplant can cure SCD. The transplant needs a donor who’s healthy, genetic match, such as a sibling. However, only about 18% of people with SCD have a compatible donor. In addition, there are complications and risks involved with a transplant.

Which treatment segment held the largest market share in the sickle cell disease treatment market?

The originators segment dominated the sickle cell disease treatment market and accounted for the largest market share in 2022.

Which distribution channel segment held the largest market share in the sickle cell disease treatment market?

The direct tender segment dominated the sickle cell disease treatment market and accounted for the largest market share in 2022.

The List of Companies - Sickle Cell Disease Treatment Market

  1. Novartis AG
  2. Pfizer Inc
  3. Emmaus Life Sciences Inc
  4. Teva Pharmaceutical Industries Ltd.
  5. Bristol-Myers Squibb Company
  6. Siklos
  7. Mylan NV
  8. Taj Pharmaceuticals Limited
  9. Apotex

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