North America Oligonucleotide Synthesis Market to Reach US$ $ 1,541.03 Mn at a CAGR of 11.2% in 2027

North America Oligonucleotide Synthesis Market to 2027 - Regional Analysis and Forecasts by Product (Synthesized Oligonucleotides, Reagents, and Equipment), Application (Research, Diagnostics, and Therapeutics), End User (Academic Research Institutes, Pharmaceutical & Biotechnology Companies, Diagnostic Laboratories, and Other End Users)

  • Report Code : TIPRE00007127
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 134
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The North America Oligonucleotide Synthesis market is expected to reach US$ $ 1,541.03 Mn in 2027 from US$ 609.90 Mn in 2018. The market is estimated to grow with a CAGR of 11.2% from 2019-2027.

The growth of the market is driven by the factors such as, rising investments in the development of pharmaceutical and biotechnology companies, funds from government bodies as well as rise in the number of market players and their focus in the oligonucleotide synthesis market are likely to boost the growth of the oligonucleotide synthesis in the region during the forecast period.

Oligonucleotides are used in many biological applications as sequence-specific binding agents can help in identifying presence of a specific target DNA sequence. Synthetic oligonucleotides are short stretches of single stranded DNA. Oligonucleotides have variety of uses in diseases diagnosis, biotechnology research, therapeutics, forensic, drug discovery, etc. Synthetic oligonucleotides are widely used in the human genetic disease diagnosis. Oligonucleotide probes are used to detect single base pair changes within human genome. For instance, sickle cell anemia which is caused by a transversion (A^T) within β-globin gene can be analyzed with labeled oligonucleotides. Under stringent hybridization conditions, it is possible to detect whether one or two of family's alleles contain the mutant gene.

Researchers are also using oligonucleotides to produce more efficient, greener chemical synthesis. By assembling oligonucleotides together into longer fragments that encode synthetic genes, bacteria or yeast cells can be instructed to produce specific enzymes (a type of protein).

Oligonucleotides also enable the development of therapeutics as the malfunctioning genes can be targeted, manipulated, silenced and/or modulated. For instance, Ionis Pharmaceuticals has dedicated its existence to oligonucleotide therapeutic development, particularly antisense oligonucleotide (ASO) therapeutics. Thus, the promising potential of synthesized oligonucleotides in various fields drives the market growth.

There have been clinical trials in Canada during the recent years, which are expected to promote the growth of oligonucleotide synthesis market. For instance, as per press release during January 2019, a phase 3 trial has been enrolling adults affected with Huntington’s disease across the United States and Canada to test the potential of the investigational therapy RG6042. RG6042, initially known as IONIS-HTTRx, is an analytical antisense oligonucleotide treatment that was earlier developed by Ionis Pharmaceuticals and later on had been acquired by Roche. It is designed to target and destroy different forms of mutant huntingtin protein (mHTT), which is the main cause of the Huntington’s disease. The trial is being expected to be conducted across six sites, across five Canadian provinces

US is expected to lead the market in the North America region owing to increasing investments and rising funds dedicated to the manufacturing companies as well as academic and research institutes for the development of gene synthesis based end products such as precision medicine and other therapeutics. Therefore, considering the above mentioned factors the growth of the market in the country is likely to contribute largest share in the North America region during the forecast period.

Mexico Oligonucleotide Synthesis Market Revenue and Forecasts to 2027 (US$ Mn)

  • Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.

NORTH AMERICA OLIGONUCLEOTIDE SYNTHESIS – MARKET SEGMENTATION

By Product

  • Synthesized Oligonucleotides
    • Primers
    • Probes
    • Large-Scale Synthesis
    • Others
  • Reagents
    • Equipment

By Application

  • Research
  • Diagnostics
  • Therapeutics

By End User

  • Academic Research Institutes
  • Pharmaceutical & Biotechnology Companies
  • Diagnostic Laboratories
  • Other End Users

By Geography

  • North America

    • US
    • Canada
    • Mexico

Company Profiles

  • Thermo Fisher Scientific Inc.
  • GenScript
  • Molecular Assemblies
  • Twist Biosciences
  • Evonetix
  • DNA Script
  • Nuclera Nucleics
  • Camena Bioscience
  • Synthomics
  • Ansa Biotechnologies
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Product, Application, End User

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

US, Canada

The List of Companies

  1. Thermo Fisher Scientific Inc.
  2. GenScript
  3. Molecular Assemblies
  4. Twist Biosciences
  5. Evonetix
  6. DNA Script
  7. Nuclera Nucleics
  8. Camena Bioscience
  9. Synthomics
  10. Ansa Biotechnologies

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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