Tissue Engineering Market Size, Analysis | Report Forecast 2028

Tissue Engineering Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Material Type (Synthetic Material, Biologically Derived Materials, and Others) and Application (Orthopedic, Musculoskeletal & Spine, Neurology, Cardiology & Vascular, Skin & Integumentary, Urology, GI & Gynecology, Cancer, and Others)

Publication Month : May 2022

  • Report Code : TIPRE00006702
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 199
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[Research Report] The tissue engineering market is expected to reach US$ 13,236.87 million in 2022 and is projected to touch US$ 29,659.93 million by 2028. It is expected to grow at a CAGR of 12.2% from 2022 to 2028.

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, material methods, and appropriate biochemical and physicochemical factors to regenerate, preserve, enhance, or replace various types of biological tissues. Tissue Engineering (TE) is a rapidly evolving discipline that aims to repair, replace, or regenerate tissues or organs by converting fundamental physics, chemistry, and biology knowledge into practical and effective materials or devices and clinical strategies.

Tissue engineering has several primary functions in medicine and research: Assisting in tissue or organ repair, including bone repair (calcified tissue), cartilage tissue, heart tissue, pancreatic tissue, and vascular tissue. The field also researches the behavior of stem cells. Stem cells can develop into many different cell types and help repair areas of the body. The 3D nature of tissue engineering allows the study of tumor architecture in a more detailed environment. It also provides an environment to test potential new drugs for these diseases. Growth in the number of R&D activities with increasing awareness of tissue engineering in emerging markets is expected to support the market growth. Developed nations have adopted technological advances in tissue engineering and regenerative medicine that contribute to expanding the global tissue engineering market

The scope of the global tissue engineering market includes material type, application, and geography. The market for tissue engineering is analyzed based on regions such as North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. The report offers insights and in-depth analysis of the global tissue engineering market emphasizing on various parameters such as market trends, technological advancements, market dynamics, and competitive landscape analysis of leading market players across the globe.

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Tissue Engineering Market: Strategic Insights

tissue-engineering-market
Market Size Value inUS$ 13,236.87 million in 2022
Market Size Value byUS$ 29,659.93 million by 2028
Growth rateCAGR of 12.2% from 2022 to 2028.
Forecast Period2022-2028
Base Year2022
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Lucrative Regions for Tissue Engineering Market

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Market Insights

Increasing Number of Road Accidents and Trauma Injuries, and Elevating Incidence of Chronic Diseases

The rising incidence of chronic diseases and increasing number of trauma injuries and road accidents are prime factors contributing to the market's growth for advanced treatment procedures, such as tissue engineering. Road accidents are among the major fatalities worldwide as they cause serious injuries to bones and organs. As per the WHO, ~20–50 million people get injured every year in road accidents. Tissue engineering offers alternatives to surgical reconstruction, transplantation, and mechanical device instruction to repair damaged tissues. The global tissue engineering market is mainly driven by a continuous need for effective regenerative treatments to treat increasing cases of diabetes, obesity, and other disorders caused by lifestyle changes, expanding geriatric population, and a rising number of trauma cases.

A spinal cord injury (SCI) refers to damage to the spinal cord that temporarily or permanently changes its function. According to the Multidisciplinary Digital Publishing Institute (MDPI), an estimated 3 million people live with traumatic SCI worldwide, with approximately 180,000 new cases reported each year. SCI often results in devastating, long-lasting neurological deficits, manifesting as dysfunction of the motor, sensory, or autonomic nervous systems below the level of injury. To thoroughly repair or regenerate damaged tissues or organs and restore their functions has been a dream of humans. The advent of Tissue Engineering and Regenerative Medicine (TERM) seems to make this possible. Tissue engineering combines cells, scaffolds, and growth factors to regenerate tissue or replace damaged or diseased tissue.

Cancer is among the leading causes of mortality worldwide, and the disease affects a huge population. Therefore, it acts as a huge financial burden on society. According to the WHO, in 2018, ~9.6 million deaths occurred due to cancer globally. However, growing research on developing effective treatments for the disease is positively impacting the market growth. Gene therapy and cell therapy are transforming the cancer treatment landscape; for example, Novartis Kymriah is used to treat diffuse large B-cell lymphoma. The launches of more such products would drive the demand for cell and gene therapy, thus fueling the global tissue engineering market in the coming years.

Material Type-Based Insights                            

Based on material type, the global tissue engineering market is segmented into synthetic material, biologically derived materials, and others. In 2022, the biologically derived materials segment is expected to lead the market. A biomaterial plays a significant role in the development of tissue engineering and biomedical devices that naturally increase the regenerative potential of tissues to restore body mechanism, in a state of deterioration. Biologically derived materials are used in creating neo-tissues in vitro that are identical to their fundamental body parts. These materials also help in tissue regeneration by a controlled presentation and on-demand release of specific chemokines at sites of injury, tissue-resembling structural, temporary biodegradable support matrices with natural and functional characteristics. However, the synthetic material segment is likely to register highest CAGR in the global tissue engineering market during the forecast period.

Global Tissue Engineering Market, by Application – 2022 & 2028

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Application-Based Insights

Based on application, the global tissue engineering market is segmented into orthopedic, musculoskeletal & spine, neurology, cardiology & vascular, skin & integumentary, urology, GI & gynecology, cancer, and others. The orthopedic, musculoskeletal & spine segment is expected to lead the market in 2022. However, the skin & integumentary segment is anticipated to register the highest CAGR in the market during the forecast period.

Ever since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency of international concern in late January 2020, medical professionals and researchers have been urging the need for comprehensive and rapid testing of citizens to plan measures that can contain the spread of the virus. COVID-19 pandemic has become the most significant challenge across the world. This challenge was frightening especially in developing countries across the globe as it will lead to reducing imports due to disruptions in global trade. Till date no definitive treatment against COVID 19 has been established. Hence, lack of definitive therapy offers significant opportunities for tissue engineering market as US FDA has recently approved use of plasma therapy for critically ill COVID 19 patients. Over time, real-time polymerase chain reaction tests and antibody tests have emerged as vital techniques for the global healthcare system to manage the outbreak. The supply chain disruptions, along with the enormous demand for effective diagnostics as well as therapeutics for the treatment of COVID 19 had put healthcare research industry in critical situation in various regions. Risks were majorly on emerging markets that face healthcare constraints and tighter financial conditions. The COVID-19 pandemic also hampered clinical trials, drug development, and the diagnostics industry's operation in the region. Also, significant disruptions to routine research activities involving tissue engineering and regenerative medicines were also observed due to the COVID-19 pandemic. A lot of industries had been affected by the crisis including tissue engineering research activities due to shutdown of research centers, lack of healthcare facilities, and increasing number of cases. However, after the establishment of COVID-19 vaccine, the research centers have commenced the studies and research on stem cells, regenerative medicine, and other therapies. Hence, the tissue engineering market in Europe is gaining attention after the COVID-19 impact.

Companies in this market commonly adopt product launches and expansion strategies to expand their footprint worldwide and meet the growing demand. Product innovation is one of the popular strategies companies take up to cater to dynamic customer demand worldwide, which also lets players maintain their brand name globally.

In April 2022, Organogenesis Inc. announced that the latest advanced wound care research on its PuraPly AM, Affinity, Apligraf, NuShield, Novachor, and Organogenesis Physician Solutions product lines, which was showcased at the 2022 Symposium on Advanced Wound Care (SAWC) Spring Conference held April 6-10, 2022, in Phoenix, Arizona.

In July 2021, Integra LifeSciences Holding Corporation announced positive clinical outcomes for PriMatrix Dermal Repair Scaffold to manage hard-to-heal diabetic foot ulcers (DFUs).

Tissue engineering – Market Segmentation

The global tissue engineering market is analyzed on the basis of material type and application. Based on material type, the market is further segmented into synthetic material, biologically derived materials, and others. Based on application, the market is segmented into orthopedic, musculoskeletal & spine, neurology, cardiology & vascular, skin & integumentary, urology, GI & gynecology, cancer, and others. By geography, the market is segmented into North America (the US, Canada, and Mexico), Europe (France, Germany, the UK, Spain, Italy, and the Rest of Europe), Asia Pacific (China, India, Japan, Australia, South Korea, and the Rest of APAC), the Middle East & Africa (Saudi Arabia, UAE, South Africa, and the Rest of the  MEA), and South & Central America (Brazil, Argentina, and the Rest of SAM).

Company Profiles

  • Stryker Corporation
  • Organogenesis Inc.
  • Cook Biotech Inc.
  • Integra Life Sciences Corporation
  • 3M
  • AbbVie Inc.
  • Medtronic
  • Zimmer Biomet
  • Baxter International Inc.
  • DePuy Synthes (Johnson & Johnson Services, Inc.)
  • B. Braun Melsungen AG
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Material Type and Application

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


What are the driving factors for the tissue engineering market across the globe?

The factors that are driving the growth of the market are the increasing incidences of chronic diseases, road accidents, and trauma injuries and technological advancements in the field of 3D tissue engineering are expected to boost the growth of the global tissue engineering market.

Who are the major players in the tissue engineering market?

The tissue engineering market majorly consists of the players such as Stryker Corporation, Organogenesis Inc., Cook Biotech Inc., Integra Life Sciences Corporation, 3M, Abbvie Inc., Medtronic, Zimmer Biomet, Baxter International Inc., DePuy Synthes (Johnson & Johnson Services, Inc.), and B. Braun Melsungen AG among others.

Which material type held the largest share in the market?

The biologically derived materials segment dominated the global tissue engineering market and held the largest market share of 52.54% in 2022.

Which application held the largest share in the market?

The orthopedic, musculoskeletal & spine segment dominated the global tissue engineering market and held the largest market share of 34.31% in 2022.

What is tissue engineering?

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, material methods, and appropriate biochemical and physicochemical factors to regenerate, preserve, enhance, or replace various types of biological tissues. Tissue Engineering (TE) is a rapidly evolving discipline that aims to repair, replace, or regenerate tissues or organs by converting fundamental physics, chemistry, and biology knowledge into practical and effective materials or devices and clinical strategies. Tissue engineering has several primary functions in medicine and research: Assisting in tissue or organ repair, including bone repair (calcified tissue), cartilage tissue, heart tissue, pancreatic tissue, and vascular tissue. The field also researches the behavior of stem cells. Stem cells can develop into many different cell types and help repair areas of the body. The 3D nature of tissue engineering allows the study of tumor architecture in a more detailed environment. Tissue engineering also provides an environment to test potential new drugs for these diseases. Growth in the number of R&D activities with increasing awareness of tissue engineering in emerging markets is expected to support the market growth. Developed nations have adopted technological advances in tissue engineering and regenerative medicine that contribute to the expansion of the global tissue engineering market.

The List of Companies – Tissue Engineering Market

  1. Stryker Corporation
  2. Organogenesis Inc.
  3. Cook Biotech Inc.
  4. Integra Life Sciences Corporation
  5. 3M
  6. AbbVie Inc.
  7. Medtronic
  8. Zimmer Biomet
  9. Baxter International Inc.
  10. DePuy Synthes (Johnson & Johnson Services, Inc.)
  11. B. Braun Melsungen AG

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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