The blood brain barrier technologies market is projected to reach US$ 5,101.94 million by 2028 from US$ 1,041.05 million in 2021; it is estimated to register a CAGR of 25.5% from 2021 to 2028.
The brain is surrounded by protective fluid known as cerebrospinal fluid and a protective membrane called the meninges. Blood brain barrier is another protective element present between the brain's blood vessels, and the cells and other components that together make up brain tissue. The blood brain barrier protects the brain against disease-causing pathogens/toxins that may be present in the blood. It blocks the passage of foreign substances entering the brain tissue. It also blocks the passage of life-saving drugs used to treat neurodegeneration and neuroinflammation events. Thus, the technologies used to deliver drugs across blood brain barrier are different than the technologies used to deliver drugs to other body parts.
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Blood Brain Barrier Technologies Market: Strategic Insights
Market Size Value in US$ 1,041.05 million in 2021 Market Size Value by US$ 5,101.94 million by 2028 Growth rate CAGR of 25.5% from 2021 to 2028 Forecast Period 2021-2028 Base Year 2021
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Blood Brain Barrier Technologies Market: Strategic Insights
| Market Size Value in | US$ 1,041.05 million in 2021 |
| Market Size Value by | US$ 5,101.94 million by 2028 |
| Growth rate | CAGR of 25.5% from 2021 to 2028 |
| Forecast Period | 2021-2028 |
| Base Year | 2021 |
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The blood brain barrier technologies market is segmented on the basis of technology, application, and geography. By geography, the market is further segmented into North America, Europe, Asia Pacific, the Middle East and Africa, and South and Central America. The report offers insights and in-depth analysis of the market, emphasizing parameters such as market trends, technological advancements, and market dynamics, along with the analysis of the competitive landscape of the globally leading market players.
Lucrative Regions for Blood Brain Barrier Technologies Market
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- Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.
Market Insights
Growing Prevalence of Neurological Disorders Drives Blood Brain Barrier Technologies Market Growth
Neurological disorders such as epilepsy and seizures, Parkinson's disease, dementia, autism, Alzheimer's disease, brain tumors, and cerebral palsy affect the brain and nerves of the human body. The prevalence of neurological disorders is increasing in the US. According to the Centers for Disease Control and Prevention (CDC), Alzheimer's disease is one of the top 10 causes of death in the US. In 2020, Alzheimer's disease affected 5.8 million people in the country. Similarly, as per the estimates of the Parkinson's Foundation Prevalence Project, the US recorded 930,000 cases of Parkinson's Disease in 2020. Additionally, according to the Alzheimer's Association estimates, more than 6 million Americans have Alzheimer's disease, and the number is projected to reach ~13 million by 2050. Moreover, deaths due to Alzheimer's and dementia have increased by 16% in the US since the COVID-19 pandemic. On the other hand, deaths due to Alzheimer's have increased by 145% during 2000–2019.
Epilepsy is a noncommunicable chronic brain disease that affects people of all ages. According to the World Health Organization (WHO), ~50 million people worldwide are suffering from epilepsy, making it one of the most common neurological diseases in the world. ~80% of people with epilepsy live in low- and middle-income countries. The same source estimates that up to 70% of people with epilepsy could live seizure free if they undergo proper diagnosis and treatment. Dementia is currently the seventh-leading cause of death among all diseases, and one of the leading causes of disability and addiction among elderly people worldwide. According to the WHO, more than 55 million people live with dementia worldwide, and there are ~10 million new cases every year. The condition is caused by a variety of diseases and injuries that primarily or secondarily affect the brain. Alzheimer's disease is the most common form of dementia and may contribute to 60–70% of cases. Thus, the growing prevalence of neurological disorders demands advanced blood-brain barrier technologies for the treatment, which is driving the market growth.
Increasing Geriatric Population and Rising Prevalence of Age-Associated Neurological Disorders Contribute to Blood Brain Barrier TechnologiesMarket Growth
Some neurologic disorders such as strokes, neuropathy, Alzheimer's disease, and Parkinson's disease are more common among the elderly populations, and their prevalence is increasing with the elevating life expectancies. According to the WHO, the population is aging rapidly worldwide. During 2015–2050, the world's population of age greater than 60 would nearly double, and its percentage would reach 22% from 12%. Mental and neurological disorders among older adults are likely to account for 6.6% of the total disability-adjusted life year (DALYs) for this age group. Also, as per the same source, ~15% of adults aged 60 and above have a mental disorder.
According to the CDC, Alzheimer's disease is the fifth leading cause of death in people with age 65 and above. Also, the number of people living with Alzheimer's disease doubles every five years. In 2020, Alzheimer's disease affected ~5.8 million Americans belonging to this age group, and by 2060, this number is expected to nearly triple to reach 14 million. The rate of mortalities caused by neurological disorders is also increasing. According to the Alzheimer's Association, 1 in 3 seniors dies with Alzheimer's disease or dementia every year in America.
Therefore, rising prevalence of age-associated neurological disorders is propelling the demand for the blood brain barrier technologies for better drug delivery.
Technology Insights
Based on technology, the global blood brain barrier technologies market is segmented into bispecific antibody RMT approach, trojan horse approach, increasing permeability, passive diffusion, and other noninvasive BBB technologies. In 2020, the increasing permeability segment held the largest share of the market. However, the reagents segment is expected to register the highest CAGR in the market during 2021–2028. Increased blood brain barrier (BBB) permeability is related with the remodeling of interendothelial junctional complex and gap formation between brain endothelial cells (paracellular pathway), and intensive pinocytotic vesicular transport between the apical and basal side of brain endothelial cells (transcellular path). The growth of the market for the increasing permeability segment can be attributed to the rising focus on research activities to treat many neurological and central nervous system disorders.
Application Insights
Based on application, the blood brain barrier technologies market is segmented into Alzheimer’s disease, epilepsy, Parkinson’s disease, multiple sclerosis, Hunter’s syndrome, brain cancer, and others. The Parkinson’s disease segment is expected to hold the largest market share in 2021.
Blood Brain Barrier Technologies Market, by Technology – 2021 and 2028
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Product launches, and mergers and acquisitions are highly adopted strategies by the players operating in the global blood brain barrier technologies market. A few of the recent key market developments are listed below:
In December 2021, Eli Lilly acquired Prevail Therapeutics, a biotechnology company. Following the deal, Lilly plans to create a gene therapy program for people with neurodegenerative diseases, including Parkinson’s.
In October 2020, Bristol Myers Squibb announced the approval of ZEPOSIA (ozanimod) by Health Canada for the treatment of patients with relapsing-remitting multiple sclerosis (RRMS) to decrease the frequency of clinical exacerbations.
According to a preliminary (yet to be peer-reviewed) research study by four Imperial College London academics, as well as other research-based evidence, the COVID-19 infection might cause neurological problems. This viewpoint developed during the first wave of the pandemic. The blood-brain barrier is a semipermeable membrane of endothelial cells that keeps the brain separated from the components and mechanisms of the rest of the body. Monocytes, a type of white blood cell, are activated as part of the body's defense mechanism when SARS-CoV-2 enters the bloodstream. To allow monocytes to cross the BBB, a complicated mechanism is activated. According to the same study, " blood-brain barrier facilitates the entry of infected and activated monocytes into the central nervous system, allowing the SARS-CoV-2 virus to pass through the loosened BBB. Hence, the rising demand for blood brain barrier technologies to detect neurological problems in COVID-19 patients is positively impacting the market growth.
Blood Brain Barrier Technologies – Market Segmentation
The global blood brain barrier technologies market is segmented into technology, application, and geography. In terms of technology, the market is segmented into bispecific antibody RMT approach, trojan horse approach, increasing permeability, passive diffusion, and other noninvasive BBB technologies. Based on application, the blood brain barrier technologies market is segmented into Alzheimer’s disease, epilepsy, Parkinson’s disease, multiple sclerosis, Hunter’s syndrome, brain cancer, and others.
Company Profiles
- Teva Pharmaceutical Industries Ltd.
- F. Hoffmann-La Roche Ltd.
- Eli Lilly and Company.
- Bristol-Myers Squibb Company
- Pfizer, Inc.
- Johnson and Johnson Services, Inc.
- Fabre-Kramer Pharmaceuticals, Inc.
- Bioasis Technologies Inc.
- Abliva AB
- JCR Pharmaceuticals Co., Ltd.
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
Technology, Application and Geography
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States
Frequently Asked Questions
The brain is surrounded by protective fluid known as cerebrospinal fluid and a protective membrane called the meninges. Similar another protective element is the blood brain barrier. this is a barrier between the brain's blood vessels and the cells and other components that together make up brain tissue. The blood brain barrier protects against disease-causing pathogens/toxins that may be present in the blood. It blocks the passage of foreign substances entering the brain tissue. It also blocks the passage of life-saving drugs used to treat neurodegeneration and neuroinflammation events. Thus, different technologies are used to deliver drugs across blood brain barrier.
Key factors driving the growth of the market are growing prevalence of neurological disorders and increasing geriatric population and neurological disorders associated with age are among the key factors driving the market.
Key players in the market are Teva Pharmaceutical Industries Ltd., F. Hoffmann-La Roche Ltd., Eli Lilly and Company., Bristol-Myers Squibb Company, Pfizer, Inc., Johnson and Johnson Services, Inc., Fabre-Kramer Pharmaceuticals, Inc., Bioasis Technologies Inc., Abliva AB, and JCR Pharmaceuticals Co., Ltd. among others.
Nanoparticles for brain drug delivery is likely to act as trend the market growth in the comping years.
Increasing permeability is the most influencing segment growing in the blood brain barrier technologies market.
Large number of product approvals and launches are likely to fuel the market growth in the comping years.
Asia-Pacific is the lucrative for the blood brain barrier technologies market.
The List of Companies - Blood Brain Barrier Technologies Market
- Teva Pharmaceutical Industries Ltd.
- F. Hoffmann-La Roche Ltd.
- Eli Lilly and Company
- Bristol-Myers Squibb Company
- Pfizer, Inc.
- Johnson and Johnson Services, Inc.
- Fabre-Kramer Pharmaceuticals, Inc.
- Bioasis Technologies Inc.
- Abliva AB
- JCR Pharmaceuticals Co., Ltd.
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- 3.1 Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- 3.2 Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- 3.3 Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- 3.4 Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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