Publication Month: Aug 2019 | Report Code: TIPRE00004479 | No. of Pages: 187 | Category: Biotechnology | Status: Published
Compound management, also referred to as compound control, is a service that provides secure compound storage and aggregation, rapid delivery of hits, and leads to the pharmaceutical, biopharmaceutical, and other contract research organization with quality control and inventory management. It includes the restoration of chemicals that are outdated, databases, robotic technology frequently engaged with fetching chemicals, and control of quality related to storage environment. Compounds that are used for research purposes start their journey from the collection, then they are stored, processed, and finally reaches the research labs for drug development. Compound management is majorly a necessary expense, and career for various individuals who are managing the chemical library.
The compound management market growth is attributed to the rising trend in outsourcing compound/sample management, rising drug discovery activities, and the ability to overcome the bottlenecks associated with the drug development process. However, large capital investments required to establish compound management facilities may hinder the growth of the market.
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Development of the drug is a complicated, long, and costly process, embedded with a high degree of improbability that a drug will succeed. Various advanced techniques are used to check the drug discovery processes. High Throughput Screening (HTS) is used in drug discovery for the screening of a large number of compounds with a biological target. The data on activity against the target is collected for a representative sample of compounds selected from an extensive library. Drug discovery aims to relate the operation of a compound to its chemical structure and therefore is used to identify more active compounds.
At present, approximately 5,000–10,000 chemical compounds should undergo laboratory screening and then should be used on humans. Out of the 5,000–10,000 compounds that are screened, about 250 enters preclinical testing, and five begins with the clinical trial. The overall process from discovery to the marketing of a drug takes around 10–15 years. The process of drug development in areas such as chemical development, high-throughput screening, formulation development, drug delivery, and assay development involves not only complications but also rules and regulations. Such rising drug discovery activities are expected to create a demand for compound management products round the world. For instance, Evotec has five compound management teams located in Europe and the US. Together, Evotec’s global compound management sites can store over 13 million compounds at different temperatures, and process and deliver more than 45 million compounds annually. The two main sites located in Branford, Connecticut, USA, and Toulouse, France handle majority of the compounds.
The NExT Diversity Libraries contain chemical scaffolds across 10 commercial suppliers and compounds that were selected to fall within the boundaries of drug-like chemical space (e.g., Lipinski's rule of five, high QED scores). They were mostly identified as novel modulators for drug target application. Commercially available chemical libraries are available to help validate HTS-amenable assays and identify potential small molecule controls. These libraries contain a number of privileged scaffolds and are often biased toward known bioactivity and polypharmacology. They are used in assay validation and control compounds identification.
The global compound management market, based on product & services, is bifurcated into compound/sample management products and services. The compound/sample management products segment accounted for a larger share in the compound management market in 2018. However, the services segment is expected to witness a higher growth from 2019 to 2027. The product manufacturing companies provide various services to pharmaceutical companies, biopharmaceuticals, and contract research organizations with regard to their compound management storage needs, and are reasonably priced.
The global compound management market, based on sample type, is divided into chemical compounds and biosamples. The chemical compounds accounted for a larger share in 2018. However, the biosamples segment is expected to witness a faster growth over the forecast period. Compound management and biological sample management both have significant influence in the drug discovery process. Additionally, the collection, storage and distribution of human biological materials supports the advancement of the R&D industry, aids understanding of the mechanisms of diseases, and fuels the trend to provide personalized medicines.
The global compound management market, based on application, is segmented into drug discovery, gene synthesis, and biobanking. In 2018, the drug discovery systems segment held the largest share and is expected to witness the highest growth over the forecast period. Rising need for fully automated procedures helps in compound weighing and dissolution, library maintenance, and assay plate preparation that radically improve drug discovery application workflows by eradicating time-consuming and error-prone tasks.
The global compound management market, based on end user, is segmented into pharmaceutical companies, biopharmaceutical companies, contract research organizations (CROs), and others. In 2018, the pharmaceutical companies segment held the largest share. On the other hand, the biopharmaceutical companies segment is expected to witness the fastest growth over the forecast period. Companies are investing to build up compound management facilities that are especially critical for innovative biotechs working with a network of contract research organizations.
Product launches and approvals are commonly adopted strategies by companies to expand their global footprints and product portfolios. Moreover, the compound management market players focus on the partnership strategy to enlarge their clientele, which, in turn, permits them to maintain their brand name across the world. The compound management market share is anticipated to flourish with the development of new innovative products by market players. Some of the companies that have been included in our research scope are Biosero Inc.; WuXi AppTec; Evotec; Icagen, Inc.; TCG Lifesciences Pvt. Ltd.; TTP Labtech; Frontier Scientific Inc.; Hamilton Company; Tecan Trading AG; and Brooks Life Sciences.
The List of Companies
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