The transient protein expression market was valued at US$ 660.00 million in 2019 and is projected to reach US$ 983.10 million by 2027; it is expected to grow at a CAGR of 5.3% from 2020 to 2027.
Transient protein expression is a procedure that is usually used to obtain a few milligrams of protein to a hundred milligrams of protein. It is a procedure expressed in a short time once the DNA encoding expression has been introduced to animal or plant cells. It is performed using an electroporation technique that allows large numbers of mutants to be screened for their abilities to network productively with receptors and effectors.
The scope of the transient protein expression market includes product type, application, end user, and geography. The transient protein expression market is analyzed based on regions such as North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. The report offers insights and in-depth analysis of the transient protein expression market emphasizing on various parameters such as market trends, technological advancements, market dynamics, and competitive landscape analysis of leading market players across the world
Lucrative Regions for Transient Protein Expression Market
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Market Insights
Transient protein expression procedure has been widely in use for animal and plant cells for the last three decades. However, in the recent few years, significant evolution in proteomics has resulted in the development of recombinant proteins. The effective results of transient protein expression in animals and plants have increased research and product development for human applications.
Various companies, including biopharmaceuticals and contract research and development organizations have channelized their efforts toward the development of products based on transient protein expression based products. The adoption of transient protein expression allow companies to get various genes to develop recombinant proteins without delaying cell line generation. Thus, the quick process of cell line development with required gene expression, companies are widely attracted towards uniform proteins that have drug-like properties, which allows production of vaccines and viral vectors. In addition, the transient protein expression process is widely being used in the production of monoclonal antibodies, modified human proteins, growth factors and cytokines, hormones, and blood products.
The COVID–19 pandemic has resulted in rise in the use of transient protein expression in vaccine development. Various researchers have started studying the novel coronavirus extensively, with the use of transient protein expression. For instance, in March–April 2020, Absolute Antibody (UK) increased the production of multigram quantities of multiple anti-SARS-CoV-2 spike proteins to develop neutralizing antibodies. Similarly, the transient protein expression was widely used to produce a positive control protein in the development of in-vitro diagnostics kits.
Growing Adoption of Precision Medicines
Technological advancements have increased the adoption of molecular biology techniques for developing various therapeutic or treatment modalities. Different therapeutic modalities utilize genomic, transcriptomic information that facilitates the discovery of biomarkers to monitor diseases and predict their risks. The use of personalized or precision medicines has dramatically risen due to the awareness regarding genetic variations among people. For instance, mRNA-mediated therapy is used for treating several diseases, as the therapy is characterized by decreased immunogenicity, superior translation efficacy, enhanced stability, pharmaceutical safety, and transient protein expression, since only the mRNA is modified without incorporating the host genome.
Similarly, pharmaceutical and biotechnology industries have developed various techniques to treat cancer and neurodegenerative diseases. Transient gene expression technique has led to significant developments in the research related to neurotrauma and neurodegenerative, and resulted in the introduction of precision medicines for these conditions. Technological advancements in epigenetics, genetics, and proteomics are supporting the development of therapeutics for the treatment of various genetic and rare genetic diseases caused by single and multiple cell disorders.
The Precision Medicine Initiative launched in the US in 2015 has enhanced the use of genetic engineering, genomics, and proteomics, thereby increasing the use of transient protein expression techniques. Thus, the continuous research and development activities, and rise in government initiatives to support precision medicine boost the adoption of transient protein expression techniques.
Product Type Insights
Based on product type, the global transient protein expression market is segmented into instruments, reagents, vectors, and competent cells. In 2019, the instruments segment held the largest market share. This segment is also expected to dominate the market in 2027 as they are the reducing human input is which enables continuous cell maintenance and protein production. Moreover, the same segment is anticipated to grow at the fastest rate during the forecast period.
Application Insights
Based on application, the global transient protein expression market is segmented into genomic research, gene therapy, bio production, cancer research, and drug development. In 2019, the genomic research segment held the largest market share in the transient protein expression market. This segment is also expected to dominate the market by 2027 as it increases DNA sequencing performance. Moreover, transient protein expression has helped in the study of all the genes of a person (the genome), including their interactions with each other as well as the environment.
End User Insights
In terms of end user, the global transient protein expression market is segmented into pharmaceutical and biotechnology companies, academic and research institutes, and clinical research organizations. In 2019, the pharmaceutical and biotechnology companies segment held the largest market share. This segment is also expected to dominate the market during the forecast period as pharmaceutical and biotechnology firms are increasing their spending on research and R&D activities. Moreover, transient protein expression has helped the recent improvements in existing technologies and it is moving toward industrial production of plant-based vaccines, antibodies, and biopharmaceuticals.
Global Transient Protein Expression Market, by End User – 2019 & 2027
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Transient Protein Expression Market: Strategic Insights
Market Size Value in US$ 660.00 Million in 2019 Market Size Value by US$ 983.10 Million by 2027 Growth rate CAGR of 5.3% from 2020-2027 Forecast Period 2020-2027 Base Year 2020
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Transient Protein Expression Market: Strategic Insights
| Market Size Value in | US$ 660.00 Million in 2019 |
| Market Size Value by | US$ 983.10 Million by 2027 |
| Growth rate | CAGR of 5.3% from 2020-2027 |
| Forecast Period | 2020-2027 |
| Base Year | 2020 |
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Product launch and mergers & acquisitions are observed as the most adopted strategy in global transient protein expression industry. A few recent key product developments are listed below:
Jan 2020:Ambrx and Sino Biopharma Announced Collaboration to Develop Two Next-Generation Biologics to develop two products enabled by Ambrx's unique non-natural amino acid incorporation technology platforms. The collaboration combines Ambrx's clinically validated ReCODE and EuCODE platforms with Sino Biopharma's strong resources and commitment to bring next-generation biologic drugs to the market.
2018:Agilent announced to sign a definitive agreement to acquire related businesses with Young In Scientific Co. Ltd., which is a leading distributor of analytical and scientific instruments in South Korea, also is a long-standing distributor of instruments and services for Agilent.
2017:Thermo Fisher Scientific Inc. launched its new PureLink Fast Low-Endotoxin Plasmid Purification Midi and Maxi Kits, which significantly reduce plasmid purification time to accelerate protein expression.
The coronavirus pandemic is estimated to have significant impact on the transient protein expression market. Majority of the pharmaceutical companies around the globe are engaged in the development of vaccines for coronavirus. However, this shift of focus is anticipated to have a negative impact on the other segments of the market. Also, disruptions in supply chain caused due to halt in global operations are projected to have an adverse impact on the market.
Transient Protein Expression – Market Segmentation
By Product Type
- Instruments
- Automated Transient Protein Expression Systems
- Manual Transient Protein Expression Systems
- Reagents
- Expression Vectors
- Competent Cells
By Application
- Genomic Research
- Gene Therapy
- Bio Production
- Cancer Research
- Drug Development
By End User
- Pharmaceutical and Biotechnology Companies
- Academic and Research Institutes
- Clinical Research Organizations
By Geography
North America
- US
- Canada
- Mexico
Europe
- France
- Germany
- UK
- Italy
- Spain
- Rest of Europe
Asia Pacific (APAC)
- China
- Japan
- India
- Australia
- South Korea
- Rest of Asia Pacific
Middle East & Africa (MEA)
- Saudi Arabia
- South Africa
- UAE
- Rest of Middle East & Africa
South America (SCAM)
- Brazil
- Argentina
- Rest of South & Central America
Company Profiles
- THERMO FISHER SCIENTIFIC INC.
- MERCK KGaA
- QIAGEN
- GenScript
- Promega Corporation
- Takara Bio Inc.
- MERIDIAN BIOSCIENCE, INC.
- New England Biolabs
- Agilent Technologies, Inc.
- Mirus Bio LLC
- Sino Biological Inc.
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
Product Type ; Application ; End User , and Geography.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, RoAPAC, RoEU, RoMEA, RoSCAM, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States
Frequently Asked Questions
Transient protein expression is a procedure that is usually used to convert a few milligrams of protein to a hundred milligrams of protein. It is a procedure expressed in a short time once the DNA encoding expression has been introduced to animal or plant cells. It is performed using an electroporation technique that allows large numbers of mutants to be screened for their abilities to network productively with receptors and effectors.
The factors that are driving growth of the market are increasing applications of protein expression and growing adoption of precision medicines are expected to boost the growth of the global transient protein expression market.
The transient protein expression market majorly consists of the players such Thermo Fisher Scientific, Promega Corporation, Merck Kgaa, Takara Bio Inc, Qiagen, Genscript, Meridian Bioscience, Inc, Agilent Technologies, Inc., New England Biolabs, And Mirus Bio Llc., Sino Biological Inc are among others.
The List of Companies - Transient Protein Expression Market
- THERMO FISHER SCIENTIFIC INC.
- MERCK KGaA
- QIAGEN
- GenScript
- Promega Corporation
- Takara Bio Inc.
- MERIDIAN BIOSCIENCE, INC.
- New England Biolabs
- Agilent Technologies, Inc.
- Mirus Bio LLC
- Sino Biological Inc.
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