Human Liver Models Market Size & Share | Forecast by 2028

Human Liver Models Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Type (Liver Organoids, Liver-on-a-Chip, 2D Models, 3D Bioprinting, and Others), Application (Drug Discovery, Educational, and Other), and End User (Pharmaceutical and Biotechnology Companies, Research Institutes, and Others)

  • Report Code : TIPRE00025128
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 178
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The human liver models market is projected to reach US$ 508.26 million by 2028 from US$ 233.90 million in 2021; it is expected to grow at a CAGR of 11.7% from 2021 to 2028.

The market's growth is primarily attributed to the increasing prevalence of liver diseases and the growing focus on developing alternatives for animal testing models. However, the high costs of human liver models and issues with incorporating liver models into existing workflow are hindering the Human Liver Models market growth. The liver is an important organ that performs vital body functions such as synthesis of blood clotting factors, bile production, protein production, and detoxification. Human liver models are used to study the drug's toxicity and enable understanding of the effect of drugs and the progression of liver disease. The rising focus on developing alternatives for the animal testing models is one of the major factors estimated to encourage the growth of the global human liver models in the next few years.

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Human Liver Models Market: Strategic Insights

human-liver-models-market
Market Size Value inUS$ 233.90 million in 2021
Market Size Value byUS$ 508.26 million by 2028
Growth rateCAGR of 11.7% from 2021-2028
Forecast Period2021-2028
Base Year2021
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The Asia Pacific biopharmaceutical industry was disturbed for a few months of 2020, owing to the COVID-19 outbreak. The COVID-19 pandemic has affected clinical trials in an unparalleled manner due to multiple levels of restrictions imposed to control the spread of infection. However, with the rising demand for products to treat the COVID-19 infection, the biopharmaceutical and pharmaceutical companies in India and China have increased their research activities, which is positively impacting the market growth.

Lucrative Regions for Human Liver Models Market

  • Sample PDF showcases the content structure and the nature of the information with qualitative and quantitative analysis.

Market Insights

Increasing Prevalence of Liver Diseases Fuel Human Liver Models Market Growth

The liver is the largest internal organ in the human body and performs over 500 functions. Liver toxicity is a major concern in risk assessment as the liver is exposed to most xenobiotic compounds and their bioactive metabolites, making it susceptible to chemically induced liver disease. Hepatitis C virus (HCV), chronic hepatitis B virus (HBV), nonalcoholic fatty liver disease (NAFLD), and alcohol-associated liver disease (ALD) are among the leading causes of chronic liver disease. Viral hepatitis continues to be the leading cause of death cases caused by liver failure, and at the same time, the NAFLD has become one of the fastest-growing contributors to liver morbidity and associated mortality. According to the national statistics of the UK, liver diseases have been ranked the fifth-leading cause of death in the country.

Furthermore, these diseases are considered the second-leading cause of death among all digestive diseases in the US. According to the American Association for the Study of Liver Diseases, in 2017, the global burden of liver cancer and cirrhosis had increased. The NAFLDs have an estimated prevalence of ~25% in the general population. Nearly a third of the US population has the NAFLD, and people with Type 2 diabetes mellitus or obesity are disproportionately affected; the number of cases with NAFLD is expected to increase from 83.1 million people in 2015 to 100.9 million by 2030. Thus, a rise in the global prevalence of liver diseases, including chronic and acute diseases and microbial infections, increases the demand for liver models.

Type-Based Insights

Based on type, the human liver models market is further segmented into liver organoids, liver-on-a-chip, 2D models, 3D bioprinting, and others. The liver organoids segment holds the largest share of the market. However, the liver-on-a-chip segment is anticipated to register the highest CAGR during 2021–2028. Advances in liver organoid technology provide models for prenatal development, tissue preservation, and pathologies, which would propel the market growth of this segment in the coming years.

Human Liver Models Market, by Type – 2021 and 2028

Human Liver Models Market, by Type – 2021 and 2028
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Application-Based Insights

Based on application, the human liver models market is further segmented into educational, drug discovery, and others. The drug discovery segment holds the largest share of the human liver models market; however, the educational segment is anticipated to register the highest CAGR during the forecast period.

End User-Based Insights

Based on end user, the human liver models market is segmented into research institutes, pharmaceutical and biotechnology companies, and others. The pharmaceutical and biotechnology companies segment holds the largest market share. However, the research institutes segment is estimated to register the highest CAGR during the forecast period. The projected market growth for this segment can be attributed to an increase in collaborations between industry and universities for genome research and technological advances in the production of human liver models.

Companies operating in the human liver models market are adopting product innovations strategy to meet the evolving customer demands worldwide, which also permits them to maintain their brand name in the global market.

Human Liver Models Market – by Type

  • Liver Organoids
  • Liver-on-a-chip
  • 2D Models
  • 3D Bioprinting
  • Others

Human Liver Models Market – by Application

  • Drug Discovery
  • Educational
  • Other 

Human Liver Models Market – by End User

  • Pharmaceutical and Biotechnology Companies
  • Research Institutes
  • Others

Human Liver Models Market – by Geography

  • North America

    • US
    • Canada
    • Mexico
  • Europe

    • France
    • Germany
    • Italy
    • UK
    • Spain
    • Rest of Europe
  • Asia Pacific (APAC)

    • China
    • India
    • South Korea
    • Japan
    • Australia
    • Rest of APAC
  • Middle East & Africa (MEA)

    • South Africa
    • Saudi Arabia
    • UAE
    • Rest of MEA
  • South and Central America (SCAM)

    • Brazil
    • Argentina
    • Rest of SCAM

Company Profiles

  • THERMO FISHER SCIENTIFIC INC.
  • Emulate, Inc.
  • CN Bio Innovations,
  • CYFUSE BIOMEDICAL K.K.
  • MIMETAS BV
  • InSphero
  • BioIVT
  • CELLINK
  • Kerafast
  • Cyprio
  • Kirkstall
  • ORGANOVO HOLDINGS INC    
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Type, Application and End User

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, RoAPAC, RoE, RoMEA, RoSCAM, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


What are the driving factors for the human liver models market across the globe?

The factors that are driving growth of the market are increasing prevalence of liver diseases, and growing focus on developing alternatives for animal testing models.

Who are the developments carrying out by major players in the human liver models market?

Various companies have made organic growth strategies in the human liver models market. Some of the activities undertaken by the company, which have promoted its growth are, launches, enhancements and expansion & relocation activities. Companies such as InSphero, Emulate, Inc amongst others are some of the companies that have been implementing various organic strategies that have helped the growth of the company.

Which region is dominated the human liver models market?

North America dominates the global human liver models market due to factors such as increasing incidences of the liver diseases such as cirrhosis, chronic liver disease (CLD), Nonalcoholic fatty liver disease (NAFLD) and others across the country. Moreover, the growth of market in Canada is expected to grow due to increasing support from the government to address the rising concerns about the liver diseases.

Which segment is growing at the highest CAGR in the human liver models market?

The liver-on-a-chip segment is growing at the highest CAGR owing to increasing demand for cost-effective alternatives to animal models for drug research and development.

Which region is the fastest growing in the human liver models market?

Asia Pacific is expected to be the fastest growing region in the Human Liver Models market. The growth of the market in this region is primarily due to growing biopharmaceutical industry, increasing number of clinical trials, and increasing research activities for the development of innovative therapies.

The List of Companies - Human Liver Models Market

  1. THERMO FISHER SCIENTIFIC INC.
  2. Emulate, Inc.
  3. CN Bio Innovations,
  4. CYFUSE BIOMEDICAL K.K.
  5. MIMETAS BV
  6. InSphero
  7. BioIVT
  8. CELLINK
  9. Kerafast
  10. Cyprio
  11. Kirkstall
  12. ORGANOVO HOLDINGS INC      

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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