Mice Model Market Share Report & Trend Analysis 2028

Mice Model Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Type (Inbred Mice, Outbred Mice, Genetically Engineered Mice, Hybrid Mice, Surgically Modified Mice, and Spontaneous Mutant Mice), Service (Breeding, Cryopreservation, Model-in Licensing, Genetic Testing, Quarantine, and Others), Technology (CRISPR, Microinjection, Embryonic Stem cell Injection, Nuclear Transfer, and Others), Indication [Oncology Studies, Immunology & Inflammation Studies, Endocrine Metabolic Studies, Cardiovascular Studies, Central Nervous System (CNS) Studies, Genetic Studies, Infectious Disease Studies, Fibrosis, and Other Disease Studies], End User (Academic & Research Institutes, Pharmaceutical & Biotechnology Companies, Contract Research Organizations, and Others), Application (Preclinical Drug Development, Biomarker Analysis, and Basic Cancer Research), and Mode (In-House and Outsourced)

Publication Month : Jun 2022

  • Report Code : TIPRE00022453
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 200
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[Research Report] The mice model market is expected to grow from US$ 1,705.70 million in 2022 to US$ 2,340.90 million by 2028; it is estimated to grow at a CAGR of 5.4% from 2022 to 2028.

Analyst Viewpoint:

Mice models play an essential role in the drug discovery process during the pre-clinical trials process. For example, mice models targeted for pre-clinical trials demonstrate metabolism and absorption with general safety and efficacy for new medicines. Also, a mouse strain with relevant disease symptoms offers a primary, effective, and efficient model that plays an important role in drug discovery. The main purpose of mice models targeted for the pre-clinical drug discovery process is due to mice having similar genomic levels and disease pathophysiology in mice similar to humans. Therefore, such a combination of features offers researchers a uniquely powerful tool to understand the mechanism of human disease and testing of novel drug therapies. Growing usage of mice models in virology and infectious disease and growing consumption of personalized medicine for studying the humanized mice models are the most impacting factors responsible for the influential growth of the mice models market during the forecast period.

Market Dynamics

Growing Usage of Mice Models in Virology and Infectious Diseases Bolster the Growth of Mice Model Market

Mice models are essential tools for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against various human pathogens. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has enabled the research community to study how pathogens cause diseases and explain the role of specific host genes in controlling or promoting diseases. It also helps determine potential targets for prevention or identify treatments for various infectious agents. With the emergence of new infectious diseases, the animal model has become a vital tool for studying disease mechanisms and developing therapeutics.

Mice with xenografted human immune systems have been used to study the pathogenesis of various infectious agents, including Plasmodium falciparum (malaria), Mycobacterium tuberculosis, dengue virus, and influenza virus. These models have been beneficial in studying HIV, which includes analyzing viral and host factors that promote viral replication and HIV interactions with the host's immune response. They are also helpful as platforms for testing therapeutic approaches to control or cure HIV infection.

Mouse models are widely used for preclinical screening of vaccines/therapies because of their reproducibility, low cost, and ease of experimental manipulation. Over the past century, advancements in vaccines, antibiotics/antivirals, and infection control measures have significantly reduced the burden of infectious diseases on public health. However, there has been an increase in contagious viral diseases over the years. In the past two decades, there have been 3 outbreaks of coronavirus─SARS-CoV in 2002, Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in 2019. However, the current SARS-CoV-2 is much more severe than the SARS-CoV in 2002 and has spread across more than 213 countries, affecting millions of people. The emergence of the novel coronavirus disease (COVID-19) in 2019 prompted the study of animal models to develop an effective treatment for it.

Aside from coronavirus studies, mouse models are considered the best small animal models to be tested for hepatitis B virus (HBV), hepatitis C virus (HCV), Zika virus, and cytomegalovirus (CMV). According to the WHO, more than 17 million people die from infectious diseases yearly. Over the past 2 decades, over 30 new infectious diseases have emerged. According to UNAIDS, 38 million people were affected by HIV by the end of 2019. Mouse models have been widely used for various viral studies due to their small size, low cost, ease of use, and high reproducibility.

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Mice Model Market: Strategic Insights

Market Size Value inUS$ 1,705.70 Million in 2022
Market Size Value byUS$ 2,340.90 Million by 2028
Growth rateCAGR of 5.4% from 2022 to 2028
Forecast Period2022-2028
Base Year2022
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Future Trends

Rising Advancements in Gene Editing Tools

Mice have been used extensively as a small animal model. Many genetically engineered mice models have emerged over the past 2 decades. The advent of gene-specific nucleases has accelerated their generation in recent years. Significant advances have been made in biotechnology in recent years, and the genetic engineering branch is advancing at an unprecedented rate, bringing numerous benefits. Genome editing technology has revolutionized genetic and biological research by providing a novel ability to precisely manipulate and modify the genomes of living organisms and accelerating the study of functional genomics.

Various genome editing tools have recently been used to study simple and complicated genomes. The development of meganuclease-engineered zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and, more recently, the CRISPR-Cas9 system has undoubtedly revolutionized genome editing and opened up new possibilities, particularly in the rat and other species, in which embryonic stem cells (ESC) were not available.

Furthermore, transgenic mice were created by incorporating Cas9 into mouse zygotes to understand the pathophysiology of cardiovascular diseases. The CRISPR-Cas9 system was used to generate Kcnj13 mutant mice to study ocular diseases. The technology also helped researchers create different types of immunodeficient mice models.

Report Segmentation and Scope

The “Global Mice Model Market” is segmented based on type, service, technology, indication, mode, application, end user, and geography. Based on type, the mice model market is segmented into inbred mice, genetically engineered mice, hybrid mice, spontaneous mutant mice, outbred mice, and surgically modified mice. Based on service, the mice model market is segmented into breeding, cryopreservation, genetic testing, model-in licensing, quarantine, and others. By technology, the mice model market is segmented as CRISPR, microinjection, nuclear transfer, embryonic stem cell injection, and others. By indication, the mice model market is segmented as oncology studies, genetic studies, infectious disease studies, endocrine metabolic studies, fibrosis, central nervous system (CNS) studies, immunology and inflammation studies, cardiovascular studies, and other disease studies. By mode, the mice model market is bifurcated into outsourced and in-house. By application, the mice model market is segmented as pre-clinical drug development, biomarker analysis, and basic cancer research. By end user, the mice model market is segmented as academic & research institutes, pharmaceutical & biotechnology companies, contract research organizations, and others. The mice model market based on geography is segmented into North America (US, Canada, and Mexico), Europe (Germany, France, Italy, UK, Russia, and Rest of Europe), Asia Pacific (Australia, China, Japan, India, South Korea, and Rest of Asia Pacific), Middle East & Africa (South Africa, Saudi Arabia, UAE, and Rest of Middle East & Africa), and South & Central America (Brazil, Argentina, and Rest of South & Central America)

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Segmental Analysis:

Based on technology, the mice model market is segmented into CRISPR, microinjection, nuclear transfer, embryonic stem cell injection, and others. The CRISPR segment held a larger share of the market in 2022 and knockout the others segment accounting least market share. The expanded form of CRISPR is Clustered Regularly Interspaced Short Palindromic Repeats. CRISPR is a highly precise gene-editing tool that can change the research landscape in mice and humans. CRISPR works in most mouse strains; thus, new mutations can be directly generated in a genetic background of choice. Thus, this technology's optimized and efficient use eliminates the need, time, and resources to backcross mutations from one genetic background to another, which is a typical practice when generating mutant mice by traditional methods.

Moreover, this technology's mice models are used to understand disease manifestation and potential therapies. For instance, a study published in Springer Nature Limited in 2021 entitled "In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice" revealed that gene therapy using "base editor" derived from CRISPR extends the life span in mice with progeria. Hutchinson-Gilford progeria syndrome (progeria) is an extremely rare, progressive genetic disorder that causes children to age rapidly, starting in their first two years. Children with progeria generally appear normal at birth. Thus, the increasing use of this technology in mice models to manipulate or edit the nucleic material is expected to contribute to the growth of this segment.

Mice Model Market, by Type – 2022 and 2030

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Based on indication, the mice models market is segmented as oncology studies, genetic studies, infectious disease studies, endocrine metabolic studies, fibrosis, central nervous system (CNS) studies, immunology and inflammation studies, cardiovascular studies, and other disease studies. The oncology studies segment is anticipated to hold the largest share of the mice model market in 2022 and is estimated to register the highest CAGR of 6.1% during the forecast period. Mouse cancer models enable researchers to learn about tumor biology in complicated and dynamic physiological systems. Metastasis is a complex process involving a series of steps in which cancer cells leave the original tumor site and move to other body parts through the bloodstream or lymphatic system. Since metastasis is one of the leading causes of cancer death, it is essential to identify the critical genetic events for metastasis. The two mouse models have been beneficial in studying metastatic genetic engineering models and xenograft model systems. Since gene targeting was developed in mice, cancer biologists have been among the most frequent users of transgenic mouse models, dramatically increasing knowledge about how cancers form and grow.

Moreover, using existing mouse models in cancer research is of utmost importance as they aim to explore the link between candidate cancer genes and carcinogenesis and provide models to develop and test new therapies. For instance, a study published in Springer Nature in 2022 entitled "Testicular cancer in mice: interplay between stem cells and endocrine insults" revealed that the Mouse model for T2GCT has immense potential to understand cancer initiation cancer stem cells and also to develop effective therapies in the near future. Therefore, the vast amount of research over the last 30 years led to the development of powerful mouse cancer models. These models are important tools for current and future cancer research, thus fueling this segment's growth.

Regional Analysis:

Based on geography, the mice models market is divided into five key regions: North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa. In 2022, North America held the largest share of the mice models market, and Asia Pacific is estimated to register the highest CAGR during the forecast period. Asia Pacific (APAC) is the fastest-growing regional market for mice models. The market in APAC is segmented into China, India, Japan, South Korea, Australia, and the Rest of APAC. Increasing prevalence of infectious and viral diseases and rising product launches are fueling the growth of the market in the region. In addition, several market players are focusing on countries in Asia Pacific for geographical expansion and other strategies. Therefore, the region holds a huge potential for mice model market players.

Industry Developments and Future Opportunities: 

Various initiatives taken by key players operating in the global mice models market are listed below:

  1. In April 2022, Taconic and LifeCanvas are collaborating to investigate how the disease develops and progresses, using advanced 3D histology with two Taconic mouse models used to study Alzheimer's disease.
  2. In January 2022, Trans Genic Inc. signed a joint research agreement on gene modification experiments using humanized mice. This joint research is a new genome editing technology has exclusively licensed the patent CRISPR-Cas3 2Regarding the usefulness of the system, the company have developed familial amyloid polyneuropathy (systemic amyloidosis). CRISPR-Cas3 This will be a study that will be evaluated using TTR exon humanized mice involved in and will lead to new gene therapies for future hereditary diseases.
  3. In January 2022, Charles River Laboratories Inc. Scientists at La Jolla Institute for Immunology (LJI) and Charles River are launched a new collaboration to uncover how different cells in the human immune system respond to early SARS-CoV-2 infection, the virus that causes COVID-19. This new research will allow scientists around the world to better capture human response during early infection.
  4. In September 2021, Envigo RMS Holding Corp. collaborated with Biocytogen. The two companies are committed to supporting research applications of the triple immunodeficient B-NDG mouse. Envigo is the exclusive provider of B-NDG mice in the United States, Europe, and certain Asia-Pacific regions. This mouse model is highly immunodeficient and capable of supporting human immune cell transplantation. The model is widely used in research and drug discovery in many fields including oncology, immuno-oncology, infectious disease, and stem cell biology.
  5. In December 2020, genOway and Cyagen, two innovative companies and leaders in the creation of genetically engineered rodent models, announced a partnership to commercialize high-standard preclinical humanized immune checkpoint and immunodeficient BRGSF mouse models to non-profit and for-profit organizations in the Asia-Pacific region from 2020.

Competitive Landscape and Key Companies:

Some of the prominent players operating in the global mice model market include Charles River Laboratories; The Jackson Laboratory; Taconic Biosciences; TRANS GENIC INC.; GenOway S.A.; Envigo; Janvier Labs; Ozgene Pty Ltd.; Crown Bioscience Inc.; and Harbour BioMed among others. These companies focus on new product launches and geographical expansions to meet the growing consumer demand worldwide and increase their product range in specialty portfolios. They have a widespread global presence, which provides them to serve a large set of customers and subsequently increases their market share.

Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Type, Service, Technology, Indication, End User, Application, and Mode

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions

What are the driving factors for the mice model market across the globe?

Increased use of mice model in virology, infectious disease, and others along with rising demand for personalized medicine and increase in R&D activities are expected to drive the mice model market.

What is the regional market scenario of the mice model market?

Global mice model market is segmented by region into North America, Europe, Asia Pacific, the Middle East & Africa, and South & Central America. In North America, the U.S. held the largest market for mice model market in 2022. The US is expected to hold the highest share in the mice model market during the forecast period. The presence of top players, presence of contract research organizations and the increase in preclinical activities by various pharmaceutical companies are the contributing factors for the regional growth. Additionally, increase in technological advancement along with surge in R&D activities are the key factor responsible for the Asia-Pacific regional growth.

Which segment led the mice model market?

Based on type, inbred mice segment held the largest share in 2022 and is expected to continue to do so till the forecast period.

What is meant by the mice model market?

A mice model is specially designed and produced in the laboratory for the study of various diseases and their treatment. The mice models are useful as they exhibit mammalian features like humans and also suffer from the various disease which are the same as humans.

Which application segment held the largest revenue (US$ Mn) in the mice model market?

The preclinical drug development segment dominated the global mice model market and is expected to account for the largest revenue of US$ 1,149.32 Mn by 2028.

Who are the key players in the mice model market?

Charles River Laboratories; The Jackson Laboratory; Taconic Biosciences; TRANS GENIC INC.; GenOway S.A.; Envigo; Janvier Labs; Ozgene Pty Ltd.; Crown Bioscience Inc.; Harbour BioMed are among the leading companies operating in the global mice model market

The List of Companies - Mice Model Market

  1. Charles River Laboratories
  2. The Jackson Laboratory
  3. Taconic Biosciences
  5. GenOway S.A.
  6. Envigo
  7. Janvier Labs
  8. Ozgene Pty Ltd.
  9. Crown Bioscience Inc.
  10. Harbour BioMed

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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