The mRNA sequencing market is projected to grow from US$ 1,356.94 million in 2022 to US$ 3,662.50 million by 2030; it is estimated to record a CAGR of 13.2% during 2022–2030.
Market Insights and Analyst View:
Factors such as mRNA sequencing accelerates diagnostic rate for rare diseases and innovative product launches propel the mRNA sequencing market growth.
Growth Drivers:
mRNA Sequencing Accelerates Diagnostic Rate for Rare Diseases
The Swedish Orphan Biovitrum AB publication state statistics revealed that, currently, more than 7,000 estimated rare/orphan diseases have been identified globally. Among these, only 5% have approved medicines globally. Therefore, there is a huge burden of healthcare costs associated with the treatment of rare diseases. The healthcare cost is approx. 10 times higher than other diseases. For example, in the US, the cost of 373 rare diseases accounts for US$2.2 trillion annually. Based on estimates, the healthcare cost for all known rare diseases may be in the range of US$ 7.2–8.6 trillion annually. Thus, rare diseases associated with difficulties and delays in diagnosis, lack of treatment availability, development of new treatment, and favorable regulatory and accessibility will result in the development of innovative technologies. Illumina's "Whole-Genome Sequencing (WGS)" is one such example that improves diagnosis for rare genetic diseases. WGS offers three key advantages over other genetic testing methods, i.e., improvement in operational efficiency, low manufacturing, and low diagnostic cost . Also, WGS is the most comprehensive test to detect multiple variant types in a single assay, proving important for rare diseases.
Thus, the increasing demand for mRNA sequencing to identify rare diseases is contributing to the growing mRNA sequencing market size.
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mRNA Sequencing Market: Strategic Insights
Market Size Value in US$ 1,356.94 million in 2022 Market Size Value by US$ 3,662.50 million by 2030 Growth rate CAGR of 13.2% from 2022 to 2030 Forecast Period 2022-2030 Base Year 2022
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mRNA Sequencing Market: Strategic Insights
Market Size Value in | US$ 1,356.94 million in 2022 |
Market Size Value by | US$ 3,662.50 million by 2030 |
Growth rate | CAGR of 13.2% from 2022 to 2030 |
Forecast Period | 2022-2030 |
Base Year | 2022 |
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Speak to AnalystReport Segmentation and Scope:
The “mRNA sequencing market analysis” has been carried out by considering the following segments: type, method, and end user.
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Segmental Analysis:
By type, the mRNA sequencing market is bifurcated into products and services. The type segment is further classified into products and services. The consumables segment held the largest mRNA sequencing market share in 2022. The service segment is anticipated to register the highest CAGR of 13.9% for the forecast period.
High-throughput mRNA sequencing is a standard technique for transcriptome discovery and identifying differential gene expression analysis in life science laboratories. Therefore, innovative product launches by the manufacturers will enhance consumables segment growth. PacBio's "SMRTbell prep kit 3.0 and binding kits 3.1 and 3.2" are examples of innovative consumables used for mRNA sequencing. Additionally, in October 2023, PacBio announced new product launches for the development of high-quality and accurate sequencing solutions, "Kinnex RNA kits." The Kinnex RNA kits increase throughput for full-length RNA, single-cell RNA, and 16S rRNA sequencing. These Kinnex kits are based on the “MAS-seq methods” where customers can transcript long chain libraries to short, increase throughput, and make the sequencing process more cost-effective.
mRNA Sequencing Market, by Method – 2022 and 2030
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Technological Advancements: A New Trend in mRNA Sequencing Market
With the technology influx, mRNA vaccines and therapeutics have an influential impact on meeting unmet medical needs. For example, the emerging mRNA sequencing technology will contribute to cancer research. Illumina's mRNA sequencing for cancer transcriptome is one such example that provides functional information about cancer gene expression and gene fusion that aids scientists in understanding tumor classification and progression. Therefore, cancer mRNA sequence can help scientists to:
· Determine variants expression in cancer samples
· Identify gene expression signatures and mutational profiles associated with the type of tumors, individual tumors, and single cells
· Finding novel small RNA's that regulate gene expression
· Identify gene fusions arising from chromosomal translocations
Likewise, the development of SARS-CoV-2 vaccines involves mRNA technology. Therefore, sequence confirmation is a critical activity during mRNA therapeutic and vaccine manufacturing. Therefore, Thermo Fisher Scientific "Sanger Sequencing" is one such technology used to develop mRNA vaccine. With mRNA vaccine manufacturing, accuracy is required at many stages of production where DNA and RNA intermediates are manipulated, wherein Sanger sequencing offers the key attributes. These attributes include simple workflow, short clinical time, and scalable workflow. Also, Thermo Fisher Scientific, using Sanger Sequencing technology, has developed a streamlined protocol for the sequencing of mRNA without the need for PCR amplification prior to cycle sequencing, shortening clinical result time and minimizing errors. Therefore, technological advancements in mRNA sequencing will ultimately open new avenues for the market growth.
Regional Analysis:
The scope of the report focuses on North America, Europe, Asia Pacific, South & Central America, and the Middle East & Africa. In 2022, North America held the largest mRNA sequencing market share. The market in this region is driven by the presence of key market players. In addition, extensive R&D by various pharmaceutical and biotechnology companies and academic & research institutes is expected to stimulate the North America mRNA sequencing market growth. The US is the largest contributor to the market in North America. It is mainly driven by the growing biotechnology sector, characterized by technological advancements. Furthermore, increasing R&D investments by US-based pharmaceutical and biotechnology companies to improve outcomes of clinical trials and ensure patient safety stimulate the market growth.
Industry Developments and Future Opportunities:
The mRNA sequencing market forecast can help stakeholders in this marketplace plan their growth strategies. A few strategic developments by leading players operating in the mRNA sequencing market are listed below:
· In November 2023, Lexogen, announced the product launch of "LUTHOR High-Definition single Cell 3 mRNA-Seq Kit". LUTHOR HD can detect single gene copy within a cell, enabling researchers to get visuals of each cell's complete transcriptome, capturing 95% of expressed genes with high magnification.
· In November 2023, PacBio, announced the expansion of "Multiplexed Arrays Sequencing (MAS-Seq) for new assays. This development is developed on the successful "MAS-Seq" concatenation technology that enables cost-effective single-cell isoform sequencing. The technology possesses key applications such as bulk RNA sequencing and 16 S rRNA, ultimately providing customers with cost-effective kit solutions and end-to-end software.
Competitive Landscape and Key Companies:
Takara Bio Inc.; Illumina, Inc.; QIAGEN; F. Hoffmann-La Roche Ltd; Quantabio; Zymo Research Corporation; baseclick GmbH; Paragon Genomics, Inc.; Yeasen Biotechnology (Shanghai) Co., Ltd.; Novogene Co, Ltd; and Norgen Biotek Corp are among the prominent companies profiled in the mRNA sequencing market report. These companies focus on developing new technologies, upgrading existing products, and expanding their geographic presence to meet the growing consumer demand worldwide.
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
Type, Method, End User, and Geography
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
This text is related
to country scope.
Frequently Asked Questions
The mRNA sequencing market majorly consists of the players such Takara Bio Inc., Illumina, Inc., QIAGEN, F. Hoffmann-La Roche Ltd, Quantabio, Zymo Research Corporation, baseclick GmbH, Paragon Genomics, Inc., Yeasen Biotechnology (Shanghai) Co.,Ltd. Novogene Co, Ltd and Norgen Biotek Corp, and amongst others.
Global mRNA sequencing market is segmented by region into North America, Europe, Asia Pacific, Middle East & Africa and South & Central America. North America held the largest market share of the mRNA sequencing market in 2022.
Illumina, Inc. and F. Hoffmann-La Roche Ltd are the top two companies that hold huge market shares in the mRNA sequencing market.
The next-generation sequencing segment dominated the global mRNA sequencing market and held the largest market share in 2022.
mRNA sequencing is a powerful technique that is used to investigate the transcriptome status of a gene including transcription level and splicing variants. Currently, several mRNA sequencing methods have been developed and three are commercially available RNA-seq library preparation kits, traditional "TruSeq", and a full-length double-stranded cDNA methods for transcriptome analysis.
The product segment held the largest share of the market in the global mRNA sequencing market and held the largest market share in 2022.
The CAGR value of the mRNA sequencing market during the forecasted period of 2022-2030 is 13.2%.
Key factors that are driving the growth of this market are identification of mRNA sequencing for diagnosis of rare diseases and innovative product launches is expected to boost the market growth for the mRNA sequencing over the years.
The List of Companies - mRNA Sequencing Market
- 1. Takara Bio Inc.
- 2. Illumina, Inc.
- 3. QIAGEN
- 4. F. Hoffmann-La Roche Ltd
- 5. Quantabio, Zymo Research Corporation
- 6. baseclick GmbH
- 7. Paragon Genomics, Inc.
- 8. Yeasen Biotechnology (Shanghai) Co.,Ltd.
- 9. Novogene Co, Ltd
- 10. Norgen Biotek Corp
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- 3.1 Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- 3.2 Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- 3.3 Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- 3.4 Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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