转染试剂和设备市场基于(关键地区、市场参与者、规模和份额)- 到 2030 年的预测

  • Report Code : TIPHE100001124
  • Category : Medical Device
  • Status : Published
  • No. of Pages : 241
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【研究报告】转染试剂及设备市场预计将从2022年的117079万美元增长到2030年的214503万美元;预计2022年至2030年复合年增长率为7.8%。
市场洞察和分析师观点:
转染试剂和设备市场规模的扩大归因于慢性病病例的增加以及人口的激增。细胞和基因疗法的普及。转染是通过化学、物理和生物手段将外来颗粒和核酸转移到细胞中的过程。转染试剂用于提高基因实验的功效,作为应用基因治疗领域进行的实质性研究的一部分。在所有转染实验中,必须仔细选择将化合物递送至细胞的方法。病毒介导的转染已显示出相当大的有效性,并且转染产物可以诱导显着的免疫反应。然而,已经开发出化学替代品来遏制与该技术中使用病毒相关的不良影响。
增长动力和挑战:
细胞和基因疗法的制造是一个复杂的过程,这使得其执行和监控至关重要。生物技术的进步导致采用个性化治疗来治疗多种适应症。细胞和基因疗法主要用于治疗神经系统疾病、癌症和遗传性疾病等慢性疾病。细胞和基因疗法的显着优势包括靶向治疗、更快、更有效的恢复以及减少副作用。由于获得美国食品和药物管理局 (FDA) 批准的产品,细胞和基因疗法在全世界得到广泛采用。例如,FDA 于 2022 年批准了由 Ferring Pharmaceuticals A/S 生产的腺病毒 ADSTILADRIN。这种重组腺病毒 (rAd-IFNa/Syn3) 将人干扰素 alfa-2b cDNA 递送到膀胱上皮细胞中,以治疗患有某些类型膀胱炎的患者。膀胱癌。 2022年,FDA批准了Janssen Biotech, Inc.生产的CARVYKTI。CARVYKTI是一种用慢病毒改造的自体CAR-T细胞,可攻击表达BCMA的肿瘤细胞,以治疗某些类型的复发或难治性多发性骨髓瘤。
根据伦敦大学学院(UCL)2020年发表的文章《基因治疗过程改变评估框架:瞬时转染和稳定生产细胞系比较》中,进行了423项正在进行的临床试验来测试基因治疗产品。现在科学家采用转染技术因此,细胞和基因治疗活动的普及推动了转染程序的数量增加,进而推动了转染试剂和设备市场的增长。
持续努力开发提高小规模转染工艺的方法是发展转染试剂和设备市场的机会转染是开发病毒载体(包括腺病毒、腺相关病毒和慢病毒)的复杂步骤。随着制造工艺规模的扩大,瞬时转染也必须加强。工艺设备供应商、药物开发商和原材料供应商正致力于合作开发具有成本效益、实用且可平台化的解决方案,以快速开发和扩大病毒载体制造工艺。通过计划的材料体积以及转移和混合时间,用多个质粒转染细胞在小规模上变得可行。由于大多数公司仅拥有实验室水平的转染经验,因此扩大规模需要工业化转染步骤的经验。然而,将工艺放大到更大水平所需的细胞培养基和转染试剂的数量可能不切实际,这强调了优化的必要性。
尽管如此,近年来,随着生产规模的激增,扩大生产规模已变得普遍。对病毒载体的需求。由于大规模转染工艺面临众多挑战,提高产量的最佳方法是减少工艺而不是扩大工艺规模。这种自上而下的方法可以清楚地识别影响工业水平过程的条件,例如转染复合物溶液的体积。这种方法还有助于流程优化和决策。
战略见解
报告细分和范围:
转染试剂和设备市场根据产品、模式、应用、最终用户和地理位置进行细分。根据产品,市场分为试剂和设备。根据模式,转染试剂和设备市场分为病毒、非病毒和混合方法。从应用来看,转染试剂和设备市场分为生物医学研究、蛋白质生产和治疗递送。转染试剂和设备市场按最终用户分为学术和研究机构以及制药和生物技术公司。根据地理位置,转染试剂和设备市场分为北美(美国、加拿大和墨西哥)、欧洲(英国、德国、法国、意大利、西班牙、俄罗斯和欧洲其他地区)、亚太地区(中国、日本) 、印度、韩国、澳大利亚、东南亚和亚太地区其他地区)、中东和非洲(阿联酋、沙特阿拉伯、南非以及中东和非洲其他地区)以及南美洲和中美洲(巴西、阿根廷) ,以及南美洲和中美洲其他地区)。
细分分析:
2022 年,基于模式的非病毒方法细分市场在转染试剂和设备市场中占有较大份额。从2022年到2030年,非病毒方法部分将录得更高的复合年增长率。非病毒转染方法可进一步分为物理/机械和化学方法。流行的物理/机械转染方法包括电穿孔、声孔、磁转染、基因显微注射和激光照射。电穿孔是一种常用的物理转染方法,利用电压瞬时增加细胞膜的通透性,使外源核酸进入细胞内。超声辅助转染或声孔技术涉及使用微泡技术在细胞膜上打孔,以方便遗传物质的转移,而激光照射辅助转染则使用激光束在质膜上打出小孔,以允许外来物质进入。遗传物质。化学转染方法可以进一步分为基于脂质体的或基于非脂质体的。基于脂质体的转染试剂可以形成带正电荷的脂质聚集体,该聚集体可以与宿主细胞的磷脂双层顺利结合,从而允许外源遗传物质以最小的阻力进入。非脂质体转染试剂可分为几类:磷酸钙、树枝状聚合物、聚合物、纳米颗粒和非脂质体脂质。病毒载体系统包括逆转录病毒、腺病毒(AdV)、腺病毒相关病毒(AAV)、慢病毒(LV)和噬菌体。目前市场上销售的基因治疗药物大多采用病毒作为载体。尽管病毒载体存在免疫原性高、安全隐患和生产困难等缺点,但其较高的转染效率为基因递送提供了独特的优势。一般来说,逆转录病毒只能用于转染分裂细胞,而腺病毒、AAV 和疱疹病毒可用于转染分裂和非分裂细胞。
转染试剂和设备市场,按产品 - 2022 年和 2030 年
2022年,按产品划分,试剂细分市场在转染试剂和设备市场中占有较大份额。 2022年至2030年,试剂领域将录得更高的复合年增长率。随着产品推出的激增以及对扩大转染工艺规模的关注,对转染试剂的需求正在增加。 2021年8月,Mirus Bio推出了TransIT VirusGEN GMP转染试剂和增强剂产品线,以支持基因治疗开发和相关流程的病毒载体制造。 TransIT VirusGEN GMP 转染试剂旨在增强将转移疫苗 DNA 递送至悬浮细胞和贴壁 HEK 293 细胞,从而更好地生产重组 AAV 和 LV 载体。人们日益关注推出符合 GMP 的转染试剂以提高载体的产能,这进一步推动了转染试剂市场的进步。
从应用来看,生物医学研究领域在 2022 年占据了转染试剂和设备市场的最大份额。该细分市场预计在 2022 年至 2030 年期间将以最快的复合年增长率增长。到 2022 年,按最终用户划分,学术和研究机构部门在转染试剂和设备市场中占据较大份额。制药和生物技术公司部门的市场预计在 2022 年至 2030 年期间将以更高的复合年增长率增长。< br>区域分析:
根据地理位置,转染试剂和设备市场分为北美、欧洲、亚太地区、中东和非洲、中南美洲。北美是全球转染试剂和设备市场增长的最大贡献者。预计从 2022 年到 2030 年,亚太地区的转染试剂和设备市场复合年增长率最高。细胞和基因疗法 (CGT) 用于治疗患有严重和罕见疾病且治疗需求未得到满足的患者。制造 CGT 是一个高度复杂的过程,基础设施和专业知识不足是主要限制因素。与中间产品和最终产品相关的物流相关挑战限制了公司的 CGT 制造能力。 CGT的制造过程包括通过“单采术”提取自体细胞,将其送往专业实验室,然后送回诊所进行患者给药,所有这些都必须在严格的质量控制下进行。迄今为止,美国食品和药物管理局 (FDA) 仅批准了 7 种 CGT 药物,新产品管线已达到约 1,200 种实验疗法。其中一半正在进行二期临床试验。正如《2023 年化学与工程新闻报告》中所述,鉴于这些前景,细胞和基因疗法的年销售额预计将分别增长 15% 和 ~30%。
许多制造商与合同开发制造组织 (CDMO) 接洽,例如Labcorp、Lonza 和 Catalent 致力于克服与其 CGT 产品生产和商业化相关的障碍。 Lonza 已投资约 920 万美元来增强其细胞和基因治疗制造能力。 CDMO 的此类举措正在促进美国转染试剂和设备市场的增长。
行业发展和未来机遇:
列出了转染试剂和设备市场主要参与者的一项突出举措如下:
2023 年 9 月,Polyplus 提供用于慢病毒载体 (LV) 合成的 FectoVIR-LV 转染试剂可供预订。由此,该公司还免费扩展了新的实验设计 (DoE) 服务,以优化转染条件,从而提高悬浮系统中的 LV 载体滴度和质量。在悬浮 HEK-293 细胞系统中,FectoVIR-LV 是增强 LV 产量的下一代转染。该试剂经过精心设计,可减少络合体积并提高复合物稳定性,同时保持其无动物成分,使其适合大规模生产。竞争格局和主要公司:
一些转染试剂领域的知名企业和设备市场包括 Thermo Fisher Scientific Inc.、Promega Corporation、Qiagen NV、Merck KGaA、Lonza Group、F.Hoffmann-La Roche Ltd、Bio-Rad Laboratories Inc.、Mirus Bio LLC、MaxCyte Inc 和 Polyplus-Transfection SA。这些公司专注于新产品发布和地域扩张,以满足全球不断增长的消费者需求,并通过专业产品组合扩大其产品范围。他们的全球业务使他们能够为大量客户提供服务,从而促进市场扩张。
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

This text is related
to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

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to country scope.

Frequently Asked Questions


What is transfection reagents and equipment?

Transfection reagents are used to improve the efficacy of genetic experiments performed as a part of substantial research in applied gene therapies. In all transfection experiments, the methods by which compounds are delivered into cells must be carefully chosen. Viral-mediated transfection has demonstrated considerable effectiveness, and the transfected products can induce significant immune responses. However, chemical alternatives have been developed to curb the ill effects associated with the use of viruses in the technique.

What are the driving and restraining factors for the transfection reagents and equipment market?

The factors driving the market include the increasing popularity of cell and gene therapy and the growing economic burden of cancer. However, the high cost of instruments and consumables hinders the market growth.

Who are the major players in the transfection reagents and equipment market?

The transfection reagents and equipment market majorly consists of players such as Thermo Fisher Scientific Inc., Promega Corporation, Qiagen N.V., Merck KGaA, Lonza Group, F.Hoffmann-La Roche Ltd, Bio-Rad Laboratories Inc., Mirus Bio LLC, MaxCyte Inc, and Polyplus-Transfection SA.

Which segment is dominating the transfection reagents and equipment market?

The transfection reagents and equipment market is fragmented based on product, modality, application, end user, and geography. Based on product, the market is classified into reagents and equipment. In 2022, the reagents segment, based on product, held a larger share of the transfection reagents and equipment market. The reagents segment will record a higher CAGR from 2022 to 2030.




Based on modality, the transfection reagents and equipment market is classified into viral, non-viral, and hybrid methods. In 2022, the non-viral methods segment, based on modality, held a larger share of the transfection reagents and equipment market. The non-viral methods segment will record a higher CAGR from 2022 to 2030.

In terms of application, the transfection reagents and equipment market is classified into biomedical research, protein production, and therapeutic delivery. Based on application, the biomedical research segment held the largest share of the transfection reagents and equipment market in 2022. The market for this segment is expected to grow at the fastest CAGR from 2022 to 2030.

The transfection reagents and equipment market, by end-user, is classified into academic and research institutes and pharmaceutical and biotechnological companies. The academic and research institutes segment accounted for a larger share of the transfection reagents and equipment market, by end user, in 2022. The market for the pharmaceutical and biotechnological companies segment is expected to grow at a higher CAGR from 2022 to 2030.

Based on geography, the transfection reagents and equipment market is segmented into North America (the US, Canada, and Mexico), Europe (the UK, Germany, France, Italy, Spain, and the Rest of Europe), Asia Pacific (China, Japan, India, South Korea, Australia, and the Rest of Asia Pacific), the Middle East & Africa (the UAE, Saudi Arabia, South Africa, and Rest of the Middle East & Africa), and South & Central America (Brazil, Argentina, and the Rest of South & Central America). North America is the largest contributor to the global transfection reagents and equipment market growth. Asia Pacific is expected to register the highest CAGR in the transfection reagents and equipment market from 2022 to 2030.

The List of Companies - Transfection Reagents And Equipment Market

  1. Thermo Fisher Scientific Inc.
  2. Promega Corporation
  3. Qiagen N.V.
  4. Merck KGaA
  5. Lonza Group
  6. F.Hoffmann-La Roche Ltd
  7. Bio-Rad Laboratories Inc.
  8. Mirus Bio LLC
  9. MaxCyte Inc
  10. Polyplus-Transfection SA.

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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