CAR-T Cell Therapy Market Developments and Forecast by 2030

Historic Data: 2020-2022   |   Base Year: 2022   |   Forecast Period: 2022-2030

CAR-T Cell Therapy Market Size and Forecasts (2020 - 2030), Global and Regional Share, Trend, and Growth Opportunity Analysis Report Coverage: By Targeted Antigen (CD19 and BCMA), Indication (Lymphomas, Leukemia, and Multiple Myeloma), End User (Hospitals and Specialty Clinics, Ambulatory Surgical Centers, and Others), and Geography (North America, Europe, Asia Pacific, and Rest of World)

  • Report Date : Sep 2025
  • Report Code : TIPRE00029935
  • Category : Life Sciences
  • Status : Data Released
  • Available Report Formats : pdf-format excel-format
  • No. of Pages : 150

[Research Report] The CAR-T cell therapy market size is projected to reach US$ 10.13billion by 2030 from US$ 2.79 billion in 2022; it is estimated to record a CAGR of 17.5% during 2022–2030.

Market Insights and Analyst View:

One of the most promising methods for treating cancer is chimeric antigen receptor (CAR) T cell therapy, and every year, an enormous number of pre-clinical and clinical trials are conducted to increase its application. After decades of research, CAR-T cell therapy will inevitably expand. In addition to autologous and allogeneic products, new in-vivo CAR-T cell gene therapies and efficacy in indications other than hematologic malignancies will also be investigated in the future of cellular therapies. However, commercializing challenges impede the CAR-T cell therapy market growth.

Growth Drivers:

Rising Prevalence of Cancer Drives CAR-T Cell Therapy Market

CAR-T cell therapy is a new cancer treatment method. T cells are modified in a lab and then returned to the body to target cancer cells. Adult and pediatric leukemia and some types of lymphoma are treated with CAR-T cell therapy. Additionally, it is being researched as a potential treatment for other cancers, such as some solid tumors that develop in the chest.

Genetic predisposition, processed foods, pollution, and altered lifestyles are the factors contributing to the increase in cancer prevalence. According to the American Cancer Society, an estimated 19.3 million new cancer cases were registered globally in 2020. Thus, the increase in the number of patients with cancer is driving the demand for CAR-T cell therapies.

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CAR-T Cell Therapy Market: Strategic Insights

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Report Segmentation and Scope:

The “CAR-T cell therapy market analysis” has been carried out by considering the following segments: targeted antigen, indication, and end user.

Segmental Analysis:

By targeted antigen, the CAR-T cell therapy market is segmented into CD19 and BCMA. The CD19 segment held a larger CAR-T cell therapy market share in 2022 and is anticipated to register a higher CAGR of 17.9% during the forecast period.

CAR-T cells effectively treat relapsed/refractory diffuse large B cell lymphoma. T cells from patients are genetically modified to produce CD19 CAR T cells. Receptors that bind to the highly expressed CD19 protein found in leukemia and lymphoma cancer cells are expressed by modified T cells.

The availability of CD19 CAR-T cell therapy products is anticipated to drive the segment's growth. Below is the list of products approved by the US Food and Drug Administration and European Union in the US and Europe, respectively:

Manufacturer

Brand Product

Target Antigen

Disease Indication

Approval Year

 
 
 

Novartis

KYMRIAH

CD19

Leukemia

2017

 

Gilead Sciences, Inc

YESCARTA

CD19

Lymphoma

2017

 

Gilead Sciences, Inc

TECARTUS

CD19

Lymphoma & Leukemia

2020

 

Bristol Myers Squibb

BREYANZI

CD19

Lymphoma

2021

 

The CAR-T cell therapy market, by indication, is divided into lymphomas, leukemia, and multiple myeloma. The lymphomas segment held a larger market share in 2022 and is anticipated to register a higher CAGR of 18.1% during the forecast period. Hematological malignancies such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphoma, and multiple myeloma have been the main indications for the use of CAR-T cells.

The CAR-T cell therapy market, by end user, is categorized into hospitals and specialty clinics, ambulatory surgical centers, and others. The hospitals and specialty clinics segment held the largest market share in 2022 and is anticipated to register the highest CAGR of 17.9% during the forecast period.

Technological Advancements to Accelerate CAR-T Cell Therapy Market Expansion

The creation and introduction of CAR-T therapy, which uses a patient's white blood cells to combat specific forms of blood cancer cells, is among the greatest medical advances of the past few years. Some cancer patients may find hope in CAR-T cell therapy as a potential cure. Five additional CAR-T cell therapies have been approved by the Food and Drug Administration (FDA) since the first therapy was approved in 2017 to treat particular types of adult and pediatric leukemia, lymphoma, and multiple myeloma. Research is also being done to create comparable treatments for solid tumor cancers.

Allogeneic CAR-T cell therapy has been the subject of hundreds of global pre-clinical and clinical trials. Most of these are used for hematological malignancies, where CD19 is the most commonly used target, along with other traditional targets such as CD20, CD22, and BCMA. Included are also newly developed targets such as CD70, CD7, and CD5. Emerging treatments for solid tumors include mesothelin, GD2, and NKG2DL.

Thus, advancements in cell-based therapeutics will likely bring new CAR-T cell therapy market trends in the coming years.

Regional Analysis:

The scope of the global CAR-T cell therapy market report focuses on North America, Europe, Asia Pacific, South & Central America, and the Rest of the World. In 2022, North America held the largest CAR-T cell therapy market share. The market growth in this region is driven by the increasing number of product launches by key manufacturers and the presence of key market players. In addition, extensive R&D by various pharmaceutical and biotechnology companies and academic & research institutes is expected to stimulate market growth in North America. For instance, in June 2022, Bristol Myers Squibb announced receiving the approval of Breyanzi (lisocabtagene maraleucel), a CD19-directed CAR-T cell therapy from the US Food and Drug Administration (FDA) for the treatment of adult patients with large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL).

In the US, the CAR-T cell therapy market growth is mainly driven by the growing pharmaceutical and biopharmaceutical sector, characterized by technological advancements and increasing flexibility. Furthermore, increasing R&D investments by US-based pharmaceutical and biotechnology companies to improve outcomes of clinical trials and ensure patient safety stimulate market growth. For instance, in July 2021, a purchase agreement was signed by BioNTech SE and Kite, a Gilead Company, allowing BioNTech to purchase Kite's clinical manufacturing facility in Gaithersburg, MD, as well as its solid tumor neoantigen T cell receptor (TCR) R&D platform. The new Gaithersburg location supplements BioNTech's current cell therapy manufacturing facility in Idar-Oberstein, Germany, and offers manufacturing capacity to strengthen clinical trials in the US. The facility helps advance the company's growing pipeline of innovative cell therapies, which includes product candidates for cancer based on NEOSTIM and CAR-T Cell Amplifying mRNA Vaccine (CARVac) and the recently acquired Individualized Neoantigen TCR program.

Future Opportunities and Research and Developments:

 CAR-T cell therapies have shown promising outcomes in cancer treatment; nevertheless, their use is restricted to patients with certain liquid tumors that are relapsed and resistant. In the upcoming years, several CAR-T cell therapies for regenerative medicine in the US and advanced therapy medical goods in Europe are anticipated to receive market authorization. Hundreds of different key players with innovative techniques are being developed for a wide range of indications. In the long run, these treatments may improve patient outcomes by offering substantial, even curative, health advantages from a single dosage.

The future of CAR-T cell treatment is quite promising, given the quantity of ongoing clinical trials and new CAR-T cell products under development for a range of indications. Researchers are motivated to investigate ways to enhance the effectiveness of CAR-T cells due to the complete response rates and progression-free survival observed in patients with relapsed/refractory malignancies who had received a lot of prior treatment.

Researchers are looking into elements like antigen loss that could lead to immune escape and are coming up with ways to deal with them. Creating CAR-T cell treatments that simultaneously target several antigens is one such tactic. New medications are being developed to target antigens, such as CD138 and GPRC5D. In contrast, CAR-T cell treatments for ALL and NHL target the CD19 antigen, and therapies for multiple myeloma target the BCMA antigen.

The CAR-T cell therapy market forecast can help stakeholders in this marketplace plan their growth strategies. A few research and developments by leading players operating in the CAR-T cell therapy market are listed below:

  • In November 2023, Vittoria Biotherapeutics declared that it completed a private financing round, raising over US$ 15 million. The funds will be utilized to conduct clinical trials of VIPER-101—an autologous dual population CD5-knockout CAR-T cell treatment for T cell lymphoma.
  • In December 2023, AstraZeneca announced the acquisition of Gracell Biotechnologies Inc. to complement AstraZeneca’s existing capabilities and previous investments in cell therapy.
  • In December 2021, researchers at the University of California San Diego School of Medicine (US) received a US$ 4.1 million grant to support the advancement of their innovative  CAR-T cell therapy. The funding, authorized by the governing board of the California Institute for Regenerative Medicine (US), may enable the group to advance novel cancer treatment from the laboratory to the patient's bed.

CAR-T Cell Therapy Market Regional Insights

The regional trends and factors influencing the CAR-T Cell Therapy Market throughout the forecast period have been thoroughly explained by the analysts at Insight Partners. This section also discusses CAR-T Cell Therapy Market segments and geography across North America, Europe, Asia Pacific, Middle East and Africa, and South and Central America.

car-t-cell-therapy-market-global-geography
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CAR-T Cell Therapy Market Report Scope

Report Attribute Details
Market size in 2022 US$ 2.79 Billion
Market Size by 2030 US$ 10.13 Billion
Global CAGR (2022 - 2030) 17.5%
Historical Data 2020-2022
Forecast period 2022-2030
Segments Covered By Targeted Antigen
  • CD19 and BCMA
By Indication
  • Lymphomas
  • Leukemia
  • Multiple Myeloma
By End User
  • Hospitals and Specialty Clinics
  • Ambulatory Surgical Centers
Regions and Countries Covered North America
  • US
  • Canada
  • Mexico
Europe
  • UK
  • Germany
  • France
  • Russia
  • Italy
  • Rest of Europe
Asia-Pacific
  • China
  • India
  • Japan
  • Australia
  • Rest of Asia-Pacific
South and Central America
  • Brazil
  • Argentina
  • Rest of South and Central America
Middle East and Africa
  • South Africa
  • Saudi Arabia
  • UAE
  • Rest of Middle East and Africa
Market leaders and key company profiles
  • Bristol-Myers Squibb Company
  • Novartis AG
  • Gilead Sciences, Inc.
  • Johnson & Johnson Services, Inc.
  • CARsgenTherapeutics Co., Ltd
  • Aurora Biopharma
  • Legend Biotech
  • Pfizer Inc.
  • bluebird bio, Inc.

  • CAR-T Cell Therapy Market Players Density: Understanding Its Impact on Business Dynamics

    The CAR-T Cell Therapy Market is growing rapidly, driven by increasing end-user demand due to factors such as evolving consumer preferences, technological advancements, and greater awareness of the product's benefits. As demand rises, businesses are expanding their offerings, innovating to meet consumer needs, and capitalizing on emerging trends, which further fuels market growth.

    Market players density refers to the distribution of firms or companies operating within a particular market or industry. It indicates how many competitors (market players) are present in a given market space relative to its size or total market value.

    Major Companies operating in the CAR-T Cell Therapy Market are:

    1. Bristol-Myers Squibb Company
    2. Novartis AG
    3. Gilead Sciences, Inc.
    4. Johnson & Johnson Services, Inc.
    5. CARsgenTherapeutics Co., Ltd

    Disclaimer: The companies listed above are not ranked in any particular order.


    car-t-cell-therapy-market-cagr

    • Get the CAR-T Cell Therapy Market top key players overview

    Competitive Landscape and Key Companies:

    Bristol-Myers Squibb Company; Novartis AG; Gilead Sciences, Inc.; Johnson & Johnson Services, Inc.; CARsgenTherapeutics Co., Ltd; Aurora Biopharma; Legend Biotech; Pfizer Inc.; bluebird bio, Inc.; Mustang Bio; Sorrento Therapeutics, Inc.; and Fate Therapeutics are among the prominent companies profiled in the CAR-T cell therapy market report. These companies focus on developing new technologies, upgrading existing products, and expanding their geographic presence to meet the growing consumer demand worldwide.


    Frequently Asked Questions

    What is CAR-T cell therapy market?

    Chimeric antigen receptor (CAR)-T cell therapy is a kind of cancer immunotherapy treatment that makes use of T cells, which are immune cells, that have undergone genetic alteration in a lab to improve their ability to recognize and eliminate cancer cells. CAR-T cell therapy is one of the newest and most promising treatments for blood cancer.

    What are the driving factors for the CAR-T cell therapy market across the globe?

    Key factors that are driving the growth of this market are new product approvals and increase in prevalence of cancer is expected to boost the market growth for the CAR-T cell therapy over the years.

    Which product segment leads the CAR-T cell therapy market?

    The CD19 segment held the largest share of the market in the global CAR-T cell therapy market and held the largest market share in 2022.

    What is the market CAGR value of CAR-T cell therapy market during forecast period?

    The CAGR value of the CAR-T cell therapy market during the forecasted period of 2022-2030 is 17.5%s

    Which application segment held the largest share in the CAR-T cell therapy market?

    The Lymphomas segment dominated the global CAR-T cell therapy market and held the largest market share in 2022.

    Which are the top companies that hold the market share in CAR-T cell therapy market?

    Gilead Sciences, Inc and Bristol Myers Squibb are the top two companies that hold huge market shares in the CAR-T cell therapy market.

    Which region is expected to witness significant demand for CAR-T cell therapy market in the coming years?

    Global CAR-T cell therapy market is segmented by region into North America, Europe, Asia Pacific, Rest of World. North America held the largest market share of the CAR-T cell therapy market in 2022.

    Who are the key players in the CAR-T cell therapy market?

    The CAR-T cell therapy market majorly consists of the players such Bristol-Myers Squibb Company, Novartis AG, Gilead Sciences, Inc., Johnson & Johnson Services, Inc., CARsgenTherapeutics Co., Ltd, Aurora Biopharma, Legend Biotech, Pfizer Inc., bluebird bio, Inc., Mustang Bio, Sorrento Therapeutics, Inc., and Fate Therapeutics, and amongst others.

    Mrinal Kerhalkar
    Mrinal Kerhalkar
    Manager,
    Market Research & Consulting

    Mrinal is a seasoned research analyst with over 8 years of experience in Life Sciences Market Intelligence and Consulting. With a strategic mindset and unwavering commitment to excellence, she has built deep expertise in pharmaceutical forecasting, market opportunity assessment, and developing industry benchmarks. Her work is anchored in delivering actionable insights that empower clients to make informed strategic decisions.

    Mrinal’s core strength lies in translating complex quantitative datasets into meaningful business intelligence. Her analytical acumen is instrumental in shaping go-to-market (GTM) strategies and uncovering growth opportunities across the pharmaceutical and medical device sectors. As a trusted consultant, she consistently focuses on streamlining workflow processes and establishing best practices, thereby driving innovation and operational efficiency for her clients.

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    The List of Companies - CAR-T Cell Therapy Market

    1. Bristol-Myers Squibb Company
    2. Novartis AG
    3. Gilead Sciences, Inc.
    4. Johnson & Johnson Services, Inc.
    5. CARsgenTherapeutics Co., Ltd
    6. Aurora Biopharma
    7. Legend Biotech
    8. Pfizer Inc.
    9. bluebird bio, Inc.
    10. Mustang Bio
    11. Sorrento Therapeutics, Inc
    12. Fate Therapeutics
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