Oligonucleotide synthesis Market Size & Trends | Report by 2027

Oligonucleotide Synthesis Market Forecast to 2027 – Global Analysis – by Product (Synthesized Oligonucleotides, Reagents, and Equipment), Application (Research, Diagnostics, and Therapeutics), and End User (Academic Research Institutes, Pharmaceutical & Biotechnology Companies, Diagnostic Laboratories, and Other End Users)

Publication Month : Mar 2019

  • Report Code : TIPBT00002549
  • Category : Biotechnology
  • Status : Published
  • No. of Pages : 174
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[Research Report] The oligonucleotide synthesis market was valued at US$ 1,584.16 million in 2018 and the oligonucleotide synthesis market size is projected to reach US$ 3,971.72 million by 2027. It is expected to register a CAGR of 11.1% in the forecast period.

Market Insights and Analyst View:

Oligonucleotide synthesis refers to the synthesis of are short fragments of nucleic acids using genetic engineering and enzyme chemistry. The technique is useful in existing laboratory practice as it provides a rapid and inexpensive access to custom-made oligonucleotides of the desired length and sequence. Oligonucleotides are used from initial research and screening through to target validation and drug production. Today, subsequent improvements in oligonucleotide synthesis, amplification and automation has completely revolutionized biological research. Increasing applications of synthesized oligonucleotides, increasing investments for synthetic biology and technological advancements genome editing tools are the key driving factors for the growth of the market in the forecast period. However, the growth of the market is restrained by factors such as renewed regulations for biotechnology and lack of skilled professionals in life science industry.

Growth Drivers and Opportunities:

Oligonucleotides have many applications in research, diseases diagnosis, therapeutics, forensic, drug discovery, agriculture and many more. Oligonucleotides are used in many biological and forensic applications as sequence-specific binding agents can help in identifying presence of a specific target DNA sequence. Synthetic oligonucleotides are short stretches of single stranded DNA fragments assembled by chemical synthesis. There is hardly a field in biology in which synthetic DNA has not been used or does not have the potential to be used. The main reason for such a turnabout is the simultaneous developments of methods for the rapid and efficient synthesis of oligonucleotides and the advent of molecular biology techniques.

Synthetic oligonucleotides are widely used in the diagnosis of human genetic diseases. Oligonucleotide probes are used to detect single base pair changes within human genome. For instance, sickle cell anemia which is caused by a transversion (A^T) within β-globin gene can be analyzed with labeled oligonucleotides. Under stringent hybridization conditions, it is possible to detect whether one or two of family's alleles contain the mutant gene. Researchers are also using oligonucleotides to produce more efficient, greener chemical synthesis. By assembling oligonucleotides together into longer fragments that encode synthetic genes, bacteria or yeast cells can be instructed to produce specific enzymes (a type of protein).

Oligonucleotides has tremendous potential for treating wide range of medical conditions. They enable the development of therapeutics as the malfunctioning genes can be targeted, manipulated, silenced and/or modulated. Ionis Pharmaceuticals has dedicated its existence to oligonucleotide therapeutic development, particularly antisense oligonucleotide (ASO) therapeutics. Thus, the promising potential of synthesized oligonucleotides in various fields drives the market growth.

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Oligonucleotide Synthesis Market: Strategic Insights

oligonucleotide-synthesis-market
Market Size Value inUS$ 1,584.16 million in 2018
Market Size Value byUS$ 3,971.72 million by 2027
Growth rateCAGR of 11.1% from 2019 to 2027.
Forecast Period2019-2027
Base Year2019
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Report Segmentation and Scope:

The “Global Oligonucleotide Synthesis Market” is segmented based on product, application end user and geography. The product segment of the oligonucleotide synthesis market is broadly segmented into synthesized oligonucleotides, reagents and equipment. The oligonucleotide synthesis market is classified on the basis of application such as research, diagnostics and therapeutics. On basis of end user market is classified into academic research institutes, pharmaceutical & biotechnology companies, diagnostic laboratories, and other end users. The oligonucleotide synthesis market based on geography is segmented into North America (US, Canada, and Mexico), Europe (Germany, France, Italy, UK, Russia, and Rest of Europe), Asia Pacific (Australia, China, Japan, India, South Korea, and Rest of Asia Pacific), Middle East & Africa (South Africa, Saudi Arabia, UAE, and Rest of Middle East & Africa), and South & Central America (Brazil, Argentina, and Rest of South & Central America)

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Segmental Analysis:

The product segment of the oligonucleotide synthesis market is broadly segmented into synthesized oligonucleotides, reagents and equipment. The companies such as Twist Bioscience, Thermo Fisher Scientific Inc., and Agilent Technologies among others are major players in the market for the oligonucleotide synthesis. The synthesized oligonucleotides is the largest segment among the products in the oligonucleotide synthesis market in 2017 and is also anticipated to hold the largest market in the year 2027. In addition to diagnostic and therapeutic purpose, oligonucleotides are also used for designing DNA microchips that are used as a powerful bio-analytical tool and novel material in the field of nanotechnology. Owing to the benefits offered by synthesized oligonucleotides, the demand for the segment is expected to grow significantly during the forecast period.

The oligonucleotide synthesis market is classified on the basis of application such as research, diagnostics and therapeutics. The market is dominated by research segment and is expected to surge significantly during the forecast period. The investments made by countries in R&D activities is expected to fuel the demand of oligonucleotide synthesis during the forecast period. For instance, in Canada, Looking ahead to 2018 and 2021, there was an increase in companies’ expected R&D spending. In both 2018 and 2021, the largest category of R&D spending was around $1 to $5 million.  In the field of research, oligonucleotides used for purposes such as, gene knockout, genotyping, and diagnosis typically need further purification after synthesis. Hence, the rise in research activities is expected to offer significant growth opportunities for the oligonucleotide synthesis market in the coming years.

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On basis of end user such as academic research institutes, pharmaceutical & biotechnology companies, diagnostic laboratories, and other end users. Moreover, many of the organizations have formed due to the partnerships between various organizations and universities for research in the transformation of scientific technologies to make the life-saving treatments for patients. For instance, TrinSeq, the Trinity Genome Sequencing Laboratory, present in Trinity Translational Medicine Institute (TTMI), Trinity College Dublin. Trinity Genome Sequencing Laboratory has an Illumina MiSeq, the gene synthesis platform for performing the ultra-high throughput genomics solutions. The facility is supported by research staff which are available to all academic and other industrial researchers in Ireland. The funding for the academic & research institutes have boosted the oligonucleotide synthesis market share.

Regional Analysis:

Based on geography, the oligonucleotide synthesis market is divided into five key regions: North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa. The market of oligonucleotide synthesis in the United States in anticipated to witness significant growth during the forecast period, owing to factors such as, rising investments in the development of pharmaceutical and biotechnology companies, funds from government bodies as well as rise in the number of market players and their focus in the oligonucleotide synthesis market. The increasing investments and rising funds dedicated to the manufacturing companies as well as academic and research institutes for the development of gene synthesis based end products such as precision medicine and other therapeutics is one of the major driving factors. According to an annual industry growth update published by SynBioBeta, a leading community of investors, entrepreneurs, and others, more than US$ 1 Bn was invested in synthetic biology by various companies in the US and worldwide. Additionally, according to a report by National Center for Biotechnology Information (NCBI), US government offers approximately US$220 million every year toward synthetic biology research and development.

Furthermore, Europe oligonucleotide synthesis market includes countries such as France, Germany, Italy, Spain, United Kingdom, and rest of Europe. The region is expected to experience a steady growth rate of 13.7% from 2018 to 2027. The European oligonucleotide synthesis market is expected to witness significant growth during the forecast period, due to factors such as, growing biotechnology industry, partnerships and collaborations undertaken by the market players as well as increasing venture capital investments. In addition, the players operating in the UK oligonucleotide synthesis market have been obtaining funds in order to enhance their product offering. For instance, in March, 2019, UK based privately held biotech company, Procarta Biosystems received a fund of US$ 1.69 Mn (€1.5 m) from the Novo Holdings REPAIR Impact Fund in order to enable the development of novel therapies to combat antimicrobial resistance (AMR). The funding would be utilized to develop a pipeline of a new class of antibiotic precision medicines from Procarta’s exclusive oligonucleotide-based antimicrobial platform. The above mentioned factors are expected to fuel the growth of oligonucleotide synthesis market in UK at a significant rate during the forecast period.

Asia Pacific includes countries such as India, China, Japan, Australia, South Korea, and Rest of Asia Pacific. The market for the oligonucleotide synthesis is expected to grow in these countries due to the growth of biotechnological industry in countries such as, Japan and China, prevalence of cancer as well as strategic developments made by the companies in the Asian market. The above mentioned factors offer significant growth opportunities for oligonucleotide synthesis market during the forecast period. In addition, Chinese government is supporting more for the genetic studies and with the support of local players. The genetic studies in China is booming to the increasing demand for the genetic sequencing. Along with the local players the international players are also investing in the country. For instance, Illumina Inc, has grown its presence in the country and has expanded its headquarters to Shanghai. The company has also introduced its BaseSpace Sequence Hub in China. The extensive genome studies are being assisted with this extended instrument of the Illumina, Inc. the instrument enables to manage and analyze data using a curated set of analysis apps and it includes the cloud base genomics data storage solutions.

Industry Developments and Future Opportunities:

Various initiatives taken by key players operating in the global oligonucleotide synthesis market are listed below:

  1. In July 2022, At its Changzhou site, WuXi STA, a division of WuXi AppTec, unveiled a brand-new large-scale oligonucleotide and peptide manufacturing plant. With this new launch, it will be better able to address the rapidly expanding global demand for oligonucleotide and peptide therapies development and manufacture.
  2. In April 2022, Bachem entered a strategic collaboration with Eli Lilly & Company to develop and manufacture active pharmaceutical ingredients based on oligonucleotides, a rising new class of complex molecules. Under the agreement, Bachem provides the appropriate engineering infrastructure and expertise to implement Lilly’s novel oligonucleotide manufacturing technology..

Covid-19 Impact: 

The market for the synthesis of oligonucleotides has been impacted by COVID-19. The need for oligonucleotide raw materials, which serve as the foundation for molecular diagnostic solutions, has increased because to the rising demand for COVID-19 diagnoses worldwide. It was discovered that the oligonucleotides successfully targeted 5'-polyUs in the coronavirus genome in a study that was published in PLOS One in March 2022. Additionally, reducing the creation and dissemination of new SARS-CoV-2 can be accomplished by creating therapeutic COVID-19 drugs that use crucial mutational sites such the 5'-polyU tract. Such studies have influenced the demand for and use of oligonucleotides in drug development, which has had an impact on the market's expansion during a pandemic. Additionally, a number of businesses are investing in oligonucleotide synthesis, which is anticipated to accelerate market expansion throughout the anticipated period. For instance, SpeeDx made a local oligonucleotide manufacturing investment in September 2021 to lower supply chain risk and provide a more essential sovereign capacity for important diagnostics. As a result of these breakthroughs, oligonucleotides are anticipated to be used more frequently in the production of pharmaceuticals, which is likely to drive market expansion over the next years.

Competitive Landscape and Key Companies:

Some of the prominent players operating in the global oligonucleotide synthesis market Molecular Assemblies, Twist Bioscience, Evonetix, Nuclera Nucleics Ltd., Camena Bio, DNA Script, Iridia, Inc., Helixworks, Ansa Biotechnologies, Inc., and Synthomics, Inc., among others. These oligonucleotide companies focus on new product launches and geographical expansions to meet the growing consumer demand worldwide and increase their product range in specialty portfolios. They have a widespread global presence, which provides them to serve a large set of customers and subsequently increases their market share. The report offers trend analysis of the oligonucleotide synthesis market emphasizing on various parameters such as technological advancements, market dynamics, and competitive landscape analysis of leading market players across the globe.

Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Product, Application, and End User

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

US, Canada, Mexico, UK, Germany, Spain, Italy, France, India, China, Japan, South Korea, Australia, UAE, Saudi Arabia, South Africa, Brazil, Argentina

Frequently Asked Questions


Which region is projected to be the fastest growing region in the global oligonucleotide synthesis market?

The Asia Pacific oligonucleotide synthesis market is expected to grow at highest rate during the forecast period owing to higher number of research & development.

Who are the key players in the oligonucleotide synthesis market?

The major key player in oligonucleotide synthesis market are Thermo Fisher Scientific Inc., DNA Script, GenScript, Synthomics, Ansa Biotechnologies, Helixworks, Molecular Assemblies, Keasling Laboratories, Nuclera Nucleics, Camena Bioscience, Evonetix, Twist Biosciences, Iridia

What are the key growth strategies of oligonucleotide synthesis market players?

Strategic acquisition and product launches were observed as the most adopted strategy in global oligonucleotide synthesis industry.

The List of Companies

  1. Thermo Fisher Scientific Inc.
  2. GenScript
  3. Molecular Assemblies
  4. Twist Biosciences
  5. Evonetix
  6. DNA Script
  7. Nuclera Nucleics
  8. Camena Bioscience
  9. Synthomics
  10. Ansa Biotechnologies
  11. Helixworks
  12. Iridia
  13. Keasling Laboratories

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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