Pulmonary Arterial Hypertension Market Developments and Forecast by 2028

The pulmonary arterial hypertension market is expected to grow from US$ 7,369.89 million in 2021 to US$ 10,889.08 million by 2028; it is estimated to grow at a CAGR of 5.8% from 2022 to 2028.

The pulmonary arterial hypertension market is segmented on the basis of drug, type, route of administration, distribution channel, and geography. The report offers insights and in-depth analysis of the pulmonary arterial hypertension market, emphasizing various parameters such as dynamics, trends, and opportunities of the market and competitive landscape analysis of leading market players across various regions. It also includes the impact analysis of COVID–19 pandemic on pulmonary arterial hypertension market across the regions.

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Pulmonary Arterial Hypertension Market: Strategic Insights

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Market Insights

Rising Approvals of Pulmonary Arterial Hypertension Drugs Drives Market Growth

• In September 2022, Toray Industries, Inc. received approval from China’s National Medical Products Administration (NMPA) for Careload tablets to treat pulmonary arterial hypertension (PAH). Careload is an orally administered sustained-release formulation of beraprost sodium, a prostacyclin derivative (PGI2).
• In May 2022, United Therapeutic Corporation received US Food and Drug Administration (FDA) approval for Tyvaso DPI (treprostinil) inhalation powder to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) and pulmonary arterial hypertension (PAH; WHO Group 1) to enhance exercise ability.
• In November 2021, the US FDA granted tentative approval for Yutrepia (treprostinil) inhalation powder. Yutrepia is indicated to treat PAH to improve exercise ability in adult patients with New York Heart Association (NYHA) Functional Class II-III symptoms.
• In July 2021, The Janssen Pharmaceutical Companies of Johnson & Johnson received FDA approval for UPTRAVI (selexipag) injection for intravenous (IV) to treat PAH; WHO Group I in adult patients with WHO functional class (FC) II–III, who are temporarily unable to take oral therapy.
• In August 2021, Aerami Therapeutics, Inc. announced that the FDA granted the company orphan drug designation for imatinib to treat PAH patients. AER– 901, a drug-device combination product candidate for inhaled imatinib for the treatment of PAH, is in a Phase 1 trial with completion targeted for the end of 2021.

The rising approvals of pulmonary arterial hypertension drugs across the world boost the growth of the pulmonary arterial hypertension market.

Drug-Based Insights

Based on drug, the pulmonary arterial hypertension market is segmented into endothelin receptor antagonists (ERAs), prostacyclin and prostacyclin analogs, sGC stimulators, and pde-5 dipsticks. The prostacyclin and prostacyclin analogs segment held the largest market share in 2021 and is anticipated to register the highest CAGR during 2022–2028. Prostacyclin is a small lipid eicosanoid molecule, also known as prostaglandin, I-2 (PGI-2), produced by endothelial cells and acts locally, inhibiting platelet activation and causing vasodilation. Prostacyclin dilates blood vessels, improves blood flow by preventing the proliferation of vascular smooth muscle cells, and prevents blood clotting by inhibiting platelet aggregation. Prostacyclin analogs have been developed as therapies for PAH. PAH prostacyclin analogs are synthetic forms of prostacyclin, a natural substance produced in the body. Patients affected by PAH tend to have reduced prostacyclin levels, leading to blood vessel constriction and hypertension. PAH prostacyclin analogs supplement the requirement and mimic the action of natural prostacyclin to reduce pulmonary hypertension and reduce associated symptoms.

Type-Based Insights

Based on type, the pulmonary arterial hypertension market is bifurcated into branded and generics. The branded segment held a larger market share in 2021 and is expected to register a higher CAGR during the forecast period. A drug company sells a branded drug under a specific name or trademark and that is protected by a patent. Brand-name drugs may be available by prescription or over the counter. Riociguat, sold under the brand name Adempas, is Bayer's medication stimulator of soluble guanylate cyclase. It is used to treat two forms of pulmonary hypertension—chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.

Route of Administration-Based Insights

Based on route of administration, the pulmonary arterial hypertension market is segmented into oral, intravenous/subcutaneous, and inhalational. The oral segment held the largest market share in 2021 and is anticipated to register the highest CAGR during the forecast period. Orally administered agents used for the treatment of symptomatic, moderate-to-severe PAH include sildenafil and the endothelin (ET) receptor antagonists (ERAs), bosentan and sitaxentan (sitaxsentan), and abrisentan oral ET(A) receptor-selective ERA, with higher ET receptor affinity than bosentan. Moreover, new oral drugs for treating PAH include macitentan, riociguat, and treprostinil. Ambrisentan is an endothelin receptor antagonist indicated for treating PAH; WHO Group 1 and delay clinical worsening. In combination with tadalafil, ambrisentan is indicated to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability.

Distribution Channel-Based Insights

Based on distribution channel, the pulmonary arterial hypertension market is segmented into hospital pharmacies and clinics, online pharmacies, and retail pharmacies. The hospital pharmacies and clinics segment held the largest market share in 2021 and is anticipated to register the highest CAGR during the forecast period. Hospital pharmacy strives to continuously maintain and improve patients' medication management and pharmaceutical care to the highest standards in a hospital setting. Pharmacists in this field are responsible for dispensing medications, quality testing, formulating and re-formulating dosage forms, monitoring, reporting drug safety, and preparing budgets for medications.

The pulmonary arterial hypertension market players adopt organic strategies, such as product launch and expansion, to expand their footprint and product portfolio across the world and meet the growing demand. Inorganic growth strategies witnessed in the market are partnerships and collaborations. These growth strategies have allowed the market players to expand their businesses and enhance their geographic presence. Additionally, acquisitions, partnerships, and other growth strategies help strengthen the company’s customer base and increase its product portfolio.

• In September 2022, Lupin launched Sildenafil for oral suspension in the US market with the US FDA approval. The drug is a generic version of Revatio for oral suspension of Viatris Specialty LLC. Sildenafil for oral suspension treats PAH.
• In February 2021, Aerami Therapeutics, Inc. signed an exclusive license and development agreement with Hangzhou Chance Pharmaceuticals Co. Ltd. (Chance) to develop and commercialize Aerami’s drug-device combination product candidate (“AER-901”) for the treatment of PAH in mainland China, Hong Kong, Macau, and Taiwan. Under the agreement, Chance is responsible for the overall development and commercialization of AER-901 for PAH in the territory.

Pulmonary Arterial Hypertension Market Regional Insights

The regional trends and factors influencing the Pulmonary Arterial Hypertension Market throughout the forecast period have been thoroughly explained by the analysts at The Insight Partners. This section also discusses Pulmonary Arterial Hypertension Market segments and geography across North America, Europe, Asia Pacific, Middle East and Africa, and South and Central America.

Pulmonary Arterial Hypertension Market Report Scope

Pulmonary Arterial Hypertension Market Players Density: Understanding Its Impact on Business Dynamics

The Pulmonary Arterial Hypertension Market is growing rapidly, driven by increasing end-user demand due to factors such as evolving consumer preferences, technological advancements, and greater awareness of the product's benefits. As demand rises, businesses are expanding their offerings, innovating to meet consumer needs, and capitalizing on emerging trends, which further fuels market growth.

Company Profiles

• Johnson & Johnson                   
• Gilead Sciences Inc                  
• United Therapeutics Corp          
• Bayer AG
• Aerami Therapeutics Holdings Inc                                                       
• Novartis AG                            
• GSK Plc                                                                               
• Lupin Ltd                                
• Pfizer Inc
• Teva Pharmaceutical Industries Ltd.